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J-GLOBAL ID：200901048974802296   Update date: Nov. 19, 2024

YAMASHITA Toshiharu

ヤマシタ トシハル | YAMASHITA Toshiharu
Affiliation and department：
University of Tsukuba Institute of Medicine

About University of Tsukuba Institute of Medicine


Job title： Assistant Professor
Research field  (1)： Molecular biology
Research theme for competitive and other funds  (2)：
  • 2018 - 2020 Molecular mechanisms and target therapy of vessel co-option and mimicry for glioblastoma
  • 2005 - 2007 the role of novel bHLH/PAS factor in hypoxic response
Papers (60)：
  • Vuong, Cat-Khanh, Fukushige, Mizuho, Ngo, Nhat-Hoang, Yamashita, Toshiharu, Obata-Yasuoka, Mana, Hamada, Hiromi, Osaka, Motoo, Tsukada, Toru, Hiramatsu, Yuji, Ohneda, Osamu. Extracellular Vesicles Derived from Type 2 Diabetic Mesenchymal Stem Cells Induce Endothelial Mesenchymal Transition under High Glucose Conditions Through the TGFβ/Smad3 Signaling Pathway. Stem cells and development. 2024. 33. 11-12. 262-275
  • Vuong, Cat-Khanh, Fukushige, Mizuho, Ngo, Nhat-Hoang, Yamashita, Toshiharu, Obata-Yasuoka, Mana, Hamada, Hiromi, Osaka, Motoo, Tsukada, Toru, Hiramatsu, Yuji, Ohneda, Osamu. Extracellular Vesicles Derived from Type 2 Diabetic Mesenchymal Stem Cells Induce Endothelial Mesenchymal Transition under High Glucose Conditions Through the TGFβ/Smad3 Signaling Pathway. Stem cells and development. 2024. 33. 11-12. 262-275
  • Nguyen, Hoai-Nga Thi, Vuong, Cat-Khanh, Fukushige, Mizuho, Usuda, Momoko, Takagi, Liora Kaho, Yamashita, Toshiharu, Obata-Yasuoka, Mana, Hamada, Hiromi, Osaka, Motoo, et al. Extracellular vesicles derived from SARS-CoV-2 M-protein-induced triple negative breast cancer cells promoted the ability of tissue stem cells supporting cancer progression. FRONTIERS IN ONCOLOGY. 2024. 14
  • Yamashita, Toshiharu, Vuong, Cat-Khanh, Ngo, Nhat-Hoang, Osaka, Motoo, Hiramatsu, Yuji, Ohneda, Osamu. Impairment of HIF-2α Expression Induced the Compensatory Overexpression of the HIF-1α/SDF-1 Axis to Promote Wound Healing. STEM CELLS AND DEVELOPMENT. 2023. 32. 19-20. 592-605
  • Ngo, Nhat-Hoang, Chang, Yun-Hsuan, Khanh, Vuong Ca, Yamashita, Toshiharu, Obata-Yasuoka, Mana, Hamada, Hiromi, Osaka, Motoo, Hiramatsu, Yuji, Ohneda, Osamu. Transformed extracellular vesicles with high angiogenic ability as therapeutics of distal ischemic tissues. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022. 10
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Books (2)：
  • HIFのin vivoモデルによる機能解析
    実験医学 羊土社 2007
  • 環境応答系転写因子の分子機構の解明
    化学工業 2003
Lectures and oral presentations  (41)：
  • Renal tubular structure and metabolism revealed by dynamic optical coherence tomography and OCT angiography
    (Dynamics and Fluctuations in Biomedical Photonics XX, Photonics West BiOS)
  • Revealing renal tubular structural metabolism without labeling by functional optical coherence tomography
    (Optics & Photonics Japan 2022)
  • Extracellular vesicles derived from Wharton’s Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1α signaling pathway
    (Tsukuba Global Science Week 2022 2022)
  • Nicotine and SARS-CoV-2 Protein Induce the Malignancy of Lung Cancer Cell. International Student Presentations of Medical and Life Sciences Session.
    (Tsukuba Global Science Week 2022 2022)
  • SARS-CoV-2 M Protein Facilitates Malignant Transformation of Breast Cancer Cells
    (Tsukuba Global Science Week 2022 2022)
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Education (2)：
  • - 2003 東北大学大学院 理学研究科 化学専攻
  • - 1996 Tohoku University Faculty of Science Department of Chemistry
Professional career (1)：
  • 博士(理学) (東北大学)
Work history (1)：
  • 2003/04 - 2005/03 JST/ERATO Research associate
Committee career (2)：
  • 2024/04 - 現在 HBP入試委員
  • 2017/02 - 現在 研究管理指導員
Association Membership(s) (4)：
The Molecular Biology Society of Japan ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  THE JAPANESE SOCIETY OF HEMATOLOGY ,  The Japanese Cancer Association
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