Rchr
J-GLOBAL ID:200901049160846418
Update date: Sep. 20, 2024
Takagi Hitoshi
タカギ ヒトシ | Takagi Hitoshi
Affiliation and department:
Research field (1):
Ophthalmology
Research keywords (1):
糖尿病網膜症 血管新生 VEGF アンジオポエチン アンジオテンシン 黄斑浮腫 循環障害
Research theme for competitive and other funds (37):
- 2020 - 2023 新規血管細胞制御シグナル伝達に介入する網膜脈絡膜血管病治療法の開発
- 2017 - 2020 Investigation of epigenetic mechanisms associated with anti-VEGF drug tolerance
- 2014 - 2017 Investigation of autophagy-regulated mechanism of vascular cell death in early diabetic retinopathy
- 2011 - 2013 Clinical evidence-based investigation of developmental mechanism in diabetic retinopathy
- 2004 - 2006 デンドリマー型薬物送達システムによる脈絡膜新生血管へのアポトーシス誘導
- 2004 - 2005 糖尿病網膜症の発症と血管前駆細胞
- 2004 - 2005 Studies on ocular neovascularization by DNA microarray and RNA interference
- 2003 - 2005 転写因子群制御による糖尿病網膜症の新規分子機構の確立
- 2003 - 2004 レーザー細隙灯と温度感受性リポソームによる脈絡膜循環の新しい観察法の開発
- 2003 - 2004 眼内血管増殖疾患の血管再生医療
- 2002 - 2003 糖尿病網膜症におけるMechanical Stressの役割
- 2001 - 2003 網膜虚血におけるミトコンドリアの役割とその調節因子の分子機構の解明
- 2001 - 2002 Treatment of Diabetic Retionpathy by Inhibition of Adhesion Molecules
- 2001 - 2002 The investigation into an intreretinal pathology and a molecular biological mechanism of diabetic retinopathy
- 2000 - 2002 The pathological investigation of proliferative diabetic retinopathy based on the control of retinal pericytes
- 2000 - 2001 増殖因子制御による血管発生の時間的・空間的解析
- 2000 - 2001 虚血に拮抗する、網膜血管に特異的な細血管拡張因子の追求
- 1999 - 2000 Elucidation of the regulatory mechanism for vascular endothelial growth factor (VEGF) expression in diabetic retinopathy
- 1999 - 2000 The role of estrogen for the etiology and treatment of intraocular inflammation and neovascularization
- 1999 - 2000 The role of leukocyte in the pathogeuesis of diabctic retiuoparthy
- 1998 - 1999 循環血中血管内皮前駆細胞の網膜血管新生における役割の解明
- 1998 - 1999 The elucidation of molecular mechanism in delayed neruonal death and its control in rat retina
- 1997 - 1998 眼内における生体分解性高分子を用いた蛋白質及び遺伝子送達の試み
- 1997 - 1998 Key Molecules involved in the Early Phase of Anterior Uveitis
- 1997 - 1998 Development of gene therapy for retinal neovascular disorders by controlling expression of VEGF
- 加齢黄斑変性の血管新生抑制療法
- 糖尿病黄斑症および加齢性黄斑変性も血管透過性抑制治療
- 糖尿病網膜症,血管新生
- 血管発生に関する研究
- 糖尿病性網膜症に関する研究
- 虚血性網膜血管新生に関する研究
- thrombolysis for the treatment of retinal vascular thrombosis
- diabetic retiropathy. angiogenesis
- antiangiogenesis against macular degeneration
- Study on Vascular development
- Study on Diabetic retinopathy
- Study on Ischemia-induced retinal neovascularization
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Papers (133):
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Ayano Yoshimura, Hiroto Ishikawa, Kazutaka Uchida, Yoshio Takesue, Junya Mori, Takamasa Kinoshita, Shohei Morikawa, Fumiki Okamoto, Tomoko Sawada, Masahito Ohji, et al. Risk Factors for Legal Blindness in 237 Japanese Patients with Exogenous Endophthalmitis: A Multicenter Cohort Study from J-CREST. Ocular immunology and inflammation. 2023. 1-9
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Takaaki Sugisawa, Hiroto Ishikawa, Kazutaka Uchida, Yoshio Takesue, Junya Mori, Takamasa Kinoshita, Shohei Morikawa, Fumiki Okamoto, Tomoko Sawada, Masahito Ohji, et al. Risk Factors for Legal Blindness in 77 Japanese Patients with Endogenous Endophthalmitis: A Multicenter Cohort Study from J-CREST. Ocular immunology and inflammation. 2022. 1-8
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Sentaro Kusuhara, Masahiko Shimura, Shigehiko Kitano, Masahiko Sugimoto, Daisuke Muramatsu, Harumi Fukushima, Yoshihiro Takamura, Makiko Matsumoto, Masahide Kokado, Jiro Kogo, et al. Treatment of diabetic macular edema in real-world clinical practice: The effect of aging. Journal of diabetes investigation. 2022. 13. 8. 1339-1346
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Yasushi Kitaoka, Kana Sase, Chihiro Tsukahara, Naoki Fujita, Ibuki Arizono, Jiro Kogo, Naoto Tokuda, Hitoshi Takagi. Axonal Protection by Netarsudil, a ROCK Inhibitor, Is Linked to an AMPK-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration. Investigative ophthalmology & visual science. 2022. 63. 1. 4-4
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Tatsuya Jujo, Jiro Kogo, Hiroki Sasaki, Reio Sekine, Keiji Sato, Sakura Ebisutani, Yasuhiro Toyoda, Yasushi Kitaoka, Hitoshi Takagi. 27-gauge trocar-assisted sutureless intraocular lens fixation. BMC Ophthalmology. 2021. 21. 1
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MISC (131):
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Masahiko Shimura, Shigehiko Kitano, Daisuke Muramatsu, Harumi Fukushima, Yoshihiro Takamura, Makiko Matsumoto, Masahide Kokado, Jiro Kogo, Mariko Sasaki, Yuki Morizane, et al. Real-world management of treatment-naïve diabetic macular oedema: 2-year visual outcome focusing on the starting year of intervention from STREAT-DMO study. The British journal of ophthalmology. 2020. 104. 12. 1755-1761
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Akira Shiono, Hiroki Sasaki, Liro Kogo, Hitoshi Takagi. Evaluation of inverted internal limiting membrane flap technique in the treatment for macular hole-associated retinal detachment in high myopia. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016. 57. 12
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Yasunari Munemasa, Yasushi Kitaoka, Kana Sase, Kaori Kojima, Akira Shiono, Jiro Kogo, Naohito Tokuda, Hitoshi Takagi. HistoneH2B, a potential role of cell death ligand, induced RGC death through Toll like receptor 4 in the vitreous of acute angle closure. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016. 57. 12
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Kana Sase, Yasushi Kitaoka, Yasunari Munemasa, Hitoshi Takagi. Atg4A in axonal protection by short-term hyperglycemia in TNF-induced optic nerve degeneration. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016. 57. 12
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Yasushi Kitaoka, Kana Sase, Yasunari Munemasa, Hitoshi Takagi. Ripasudil, a ROCK inhibitor, modulates p62 expression in TNF-induced optic nerve degeneration. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016. 57. 12
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Works (3):
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高血糖依存性遺伝子の同定
2002 - 2003
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網膜血管新生におけるアンジオテンシン受容体阻害薬の効果
2002 - 2003
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糖尿病網膜症におけるセロトニン受容体阻害薬の作用
2001 - 2002
Education (4):
- - 1994 Kyoto University
- - 1994 Kyoto University Graduate School, Division of Medicine
- - 1987 Kyoto University Faculty of Medicine
- - 1987 Kyoto University Faculty of Medicine
Professional career (1):
Work history (9):
- 2013 - 現在 St.Marianna University School of Medicine Faculty of Medicine
- 2009 - St.Marianna University School of Medicine Faculty of Medicine
- 2005 - Kyoto University Faculty of Medicine
- 1999 - Kyoto University Graduate School of Medicine
- 1996 - Kyoto University Graduate School of Medicine
- 1994 - Harvard大学 Joslin Diabetes Center留学
- 1994 - Kyoto University Graduate School of Medicine
- 1989 - 天理よろず相談所病院
- 1987 - Kyoto University Faculty of Medicine
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Awards (2):
- 2001 - 日本眼科学会学術奨励償
- 2001 - ロート賞PhotoAward
Association Membership(s) (3):
アメリカ眼科アカデミー(American Academy of Ophthalmology)
, 糖尿病眼学会
, 眼科学会
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