SHIBATA Masa-Aki

シバタマサアキ | SHIBATA Masa-Aki

Affiliation and department：
Job title： Meritorious Professor
Homepage URL (1)： http://www.osaka-med.ac.jp/deps/an1

Research field (3)： Experimental pathology , Cell biology , Molecular biology

Research keywords (9)： Atherosclerosis , atherosclerosis , Metastasis suppression , Exosomes , 癌遺伝子治療 , 乳癌 , Electrogene transfer , Cancer gene therapy , Mammary cancer

Research theme for competitive and other funds (19)：

2021 - 2024 Development of therapeutic strategies for the realization of tumor suppressive microRNA replacement therapy for refractory solid tumors
2021 - 2024 Suppression of mammary cancer metastasis by exosome-associated gene deletion by CRISPR/Cas9 system
2018 - 2021 エクソソーム分泌阻害と抗脈管新生に関わる遺伝子との複合治療による乳癌転移阻止
2016 - 2020 Highly metastatic mouse mammary carcinoma cells decrease suppressive miRNAs via exosome
2013 - 2016 Mouse mammary carcinoma cell lines release microvesicles containing precurcer VEGF-C

2011 - 2016 アポC3をターゲットとした高中性脂肪症、動脈硬化症に対する革新的核酸医薬の開発

2011 - 2014 テネイシンC抗体とα-マンゴスチンとの複合投与による乳癌リンパ節転移阻止の試み

2011 - 2013 Reproductive roles of the adipsin/ASP pathway mediated by immunological and lipid methabolic effects

2010 - 2012 CEACAM-1 promotes lymphangiogenesis and angiogenesis in the inoculated mouse mammary carcinomas.

2009 - 2011 SATB1・VEGF-C siRNAとデコイベクターによる乳癌リンパ節転移阻止

2007 - 2008 Lymphangiogenesis and lymph node-metastasis in the inoculated mouse mammary carcinomas

2007 - 2008 Inhibition of lymph node metastasis of mammary cancer due to functional loss of lymphangiogenesis factors by siRNA and/or decoy vectors

2006 - 2007 Study of the anti-cancer treatment that controls the interactions between breast cancer and its micro-environment for inhibition of invasion and metastasis.

2005 - 2006 Short interfering RNA vectors against VEGF-C and VEGF-A suppress lymphatic metastasis and lymphatic metastasis of mammary cancer model

2005 - 悪性腫瘍征圧に向けての先端的治療法の開発-局所制御と遠隔転移の制御(臨床応用に向けた基礎研究から臨床研究まで)

2003 - 2004 Combination cancer gene therapy in endostatin and suicide gene for metastatic murine mammary cancers

2000 - 2002 Gene therapy using apoptosis-inducer bax and suicide gene for chemically induced rat bladder cancer

2000 - 2001 Intracellular signal pathway of heat-induced apoptosis in human lung cancer cell lines

2000 - アポトーシス誘導遺伝子による癌遺伝子治療の基礎研究

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Papers (128)：

Ayana Ikari, Yuko Ito, Kohei Taniguchi, Masa-Aki Shibata, Kosei Kimura, Mitsuhiko Iwamoto, Sang-Woong Lee. Role of CD44-Positive Extracellular Vesicles Derived from Highly Metastatic Mouse Mammary Carcinoma Cells in Pre-Metastatic Niche Formation. International journal of molecular sciences. 2024. 25. 17
Jun Arima, Kohei Taniguchi, Nobuhiko Sugito, Kazuki Heishima, Yoshihisa Tokumaru, Yosuke Inomata, Kazumasa Komura, Tomohito Tanaka, Masa-Aki Shibata, Sang-Woong Lee, et al. Antitumor effects of chemically modified miR-143 lipoplexes in a mouse model of pelvic colorectal cancer via myristoylated alanine-rich C kinase substrate downregulation. Molecular Therapy - Nucleic Acids. 2023. 34. 102079-102079
Masa-Aki Shibata, Kohei Taniguchi. Metastasis Inhibition. Int J Mol Sci. 2023. 24. 7123
冨永智, 谷口高平, 柴田雅朗, 赤尾幸博, 木村光誠, 猪俣陽介, 碇彩菜, 前沢早紀, 坂根純奈, 田中亨明, et al. 合成microRNA-145-5pの乳癌抗がん効果の検証. 日本乳癌学会総会プログラム抄録集. 2022. 30回. EP1-8
Minoru Numata, Akane Hirano, Yukika Yamamoto, Michiko Yasuda, Nobuhiko Miura, Kazutoshi Sayama, Masa-Aki Shibata, Tomohiro Asai, Naoto Oku, Noriyuki Miyoshi, et al. Metastasis of Breast Cancer Promoted by Circadian Rhythm Disruption due to Light/Dark Shift and its Prevention by Dietary Quercetin in Mice. Journal of Circadian Rhythms. 2021. 19. 1. 2-2

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MISC (51)：

冨永智, 谷口高平, 柴田雅朗, 小村和正, 赤尾幸博, 木村光誠, 猪俣陽介, 碇彩菜, 前沢早紀, 岩本充彦, et al. 乳癌高転移マウス細胞に対する合成microRNA-145-5pの抗がん効果の検証. 日本癌治療学会学術集会抄録集. 2020. 58回. P-67
柴田雅朗, 谷口高平, 谷口高平, 奥崎大介, 伊藤裕子, 白岡千夏, 生出林太郎, 近藤洋一. 乳癌転移モデルにおけるリンパ節転移前および転移後微小環境のマイクロRNA発現プロファイル. 日本解剖学会総会・全国学術集会講演プログラム・抄録集. 2020. 125th
圓見純一郎, 柴田映子, 柴田雅朗, 森本めぐむ, 福田肇, 橋川美子, 河嶋秀和, 堀美香, 斯波真理子, 飯田秀博. Gadofluorine Mによるマウスの動脈硬化プラークイメージング. JSMI Rep. 2014. 7. 2. 155-155
柴田雅朗, 日下部守昭, 森本純司, 柴田映子, 斯波真理子, 的場吉信, 土佐秀樹, 飯沼宗和. テネイシン抗体とα-マンゴスチンとの複合投与による乳癌転移抑制の試み. 乳癌基礎研究. 2014. 22. 9-14
柴田雅朗, 日下部守昭, 柴田映子, 森本純司, 斯波真理子, 飯沼宗和. テネイシンC抗体またはα-マンゴスチンの単独投与ならびにそれらの複合投与によるマウス乳癌転移抑制. 日本毒性病理学会講演要旨集. 2014. 30回. 58-58

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Books (13)：

Ito's Toxicologic Pathology
2013
病気の分子形態学
学際企画 2011
理学療法士・作業療法士・言語聴覚士のための解剖学
廣川書店 2010
Apoptotic Detection Methods-from Morphology to Gene (jointly worked)
Progress in Histochemistry and Cytochemistry, Urban & Fischer 2003
Pathology of Tumours in Laboratory Animals Volume 3 (jointly worked)
IARC Scientific Publications 1996

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Work history (9)：

2022/04 - 現在 Osaka Medical and Pharmaceutical University Department of Anatomy and Cell Biology, Division of Life Sciences, Faculty of Medicine Meritorious Professor
2016/08 - 現在大阪保健医療大学保健医療学部客員教授
2021/04 - 2022/03 Osaka Medical and Pharmaceutical University
2016/08 - 2021/03 Osaka Medical College Division of Life Scieces, Department of Cell Biology and Anatomy Associate Professor
2013/04 - 2016/07 Osaka Health Science University

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Committee career (11)：

2023/04 - 現在日本毒性病理学会編集委員
2009 - 現在乳癌基礎研究会評議委員、幹事
1996 - 2021/12 アメリカ癌学会アクティブ会員
1996 - 2021/12 American Association for Cancer Research Active member
2013/04 - 2021/03 日本毒性病理学会評議員

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Awards (2)：

1998 - NIH研究優秀賞 (NIH Fellows Award for Research Excellence)
1998 - NIH Fellows Award for Research Excellence

Association Membership(s) (10)：

日本解剖学会 , 日本臨床分子形態学会 , アメリカ癌学会 , 日本毒性病理学会 , 日本癌学会 , Clinical Electron Microscopy Society of Japan , Japanese Association of Anatomists , Japanese Society of Toxicology Pathology , Japanese Cancer Association , American Association for Cancer Research

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