Rchr
J-GLOBAL ID：200901049403950472   Update date: Nov. 27, 2024

Oka Natsuhisa

オカ ナツヒサ | Oka Natsuhisa
Affiliation and department：
Gifu University Faculty of Engineering, Department of Chemistry and Biomolecular Science

About Gifu University Faculty of Engineering, Department of Chemistry and Biomolecular Science


Job title： Professor
Other affiliations (4)：
  • Gifu University  iGCORE   Professor
  • Gifu University  Institute for Advanced Study, Center for One Medicine Innovative Translational Research   Professor
  • Gifu University  Institute for Advanced Study, Artificial Intelligence Advanced Research Center   Professor
  • Gifu University  Institute for Advanced Study, Gu Composites Center   Professor
Homepage URL  (1)： https://www1.gifu-u.ac.jp/~oka_ap/
Research field  (5)： Bioorganic chemistry ,  Molecular biochemistry ,  Synthetic organic chemistry ,  Pharmaceuticals - chemistry and drug development ,  Biochemistry
Research keywords  (34)： unsaturated carbocycle ,  organosilicon compounds ,  heteroatom ,  nucleic acid ,  carbohydrate ,  synthetic chemistry ,  Nucleic acid chemistry ,  有機合成化学 ,  核酸化学 ,  酵素応答性分子 ,  アデニロコハク酸合成酵素 ,  ヌクレオシド ,  リン原子修飾DNA類縁体 ,  ホスホロアミダイト ,  不斉合成 ,  固相合成 ,  立体選択的 ,  オキサザボスホリジン ,  リン原子修飾DNA ,  リン原子修飾核酸 ,  蛍光プローブ ,  立体選択性 ,  ホスホロアミデート ,  イノシン ,  核酸の生合成 ,  CTP合成酵素 ,  ホスファイト ,  蛍光標識化 ,  H-ホスホネート ,  カルボニル基のリン酸化 ,  ホスホロチオエート ,  ヌクレオチド ,  DNA ,  核酸医薬
Research theme for competitive and other funds  (16)：
  • 2021 - 2024 新規ドミノ反応を用いる多置換不飽和環状炭化水素の立体選択的合成法の開発
  • 2018 - 2024 化学を基盤とするゲノムスケールDNA合成技術の開発
  • 2017 - 2020 A study on the biosynthesis of guanosine monophosphate and the development of functional molecules targeting guanosine monophosphate synthetase
  • 2013 - 2016 Stereoselective synthesis of alkenes using new Julia-type reagents
  • 2014 - 2016 カルボニル基のリン酸化反応を利用した核酸の生合成中間体の合成法の開発
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Papers (59)：
  • Rini Retnosari, Muhamad Adib Abdul Ghani, Munirah Majed Alkharji, Wan Nur Izzah Shazana Wan Nawi, Ahmad Syafi Ahmad Rushdan, Moh, Kaisan Mahadi, Azizah Ugusman, Natsuhisa Oka, Satirah Zainalabidin, Jalifah Latip. The Protective Effects of Carvacrol Against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo. Cardiovascular Toxicology. 2024. in press
  • Rini Retnosari, Kentaro Oh-hashi, Azizah Ugusman, Satirah Zainalabidin, Jalifah Latip, Natsuhisa Oka. Carvacrol-conjugated 3-Hydroxybenzoic Acids: Design, Synthesis, cardioprotective potential against doxorubicin-induced Cardiotoxicity, and ADMET study. Bioorganic & Medicinal Chemistry Letters. 2024. 113. 129973
  • Shu Fujita, Yuzuru Sugio, Takuya Kawamura, Ryota Yamagami, Natsuhisa Oka, Akira Hirata, Takashi Yokogawa, Hiroyuki Hori. ArcS from Thermococcus kodakarensis transfers L-lysine to preQ0 nucleoside derivatives as minimum substrate RNAs. Journal of Biological Chemistry. 2024. 300. 8. 107505
  • Rini Retnosari, Amatul Hamizah Ali, Satirah Zainalabidin, Azizah Ugusman, Natsuhisa Oka, Jalifah Latip. The recent discovery of a promising pharmacological scaffold derived from carvacrol: A review. Bioorganic & Medicinal Chemistry Letters. 2024. 129826
  • Kohei Nomura, Kaoru Onda, Hirotaka Murase, Fumitaka Hashiya, Yukiteru Ono, Goro Terai, Natsuhisa Oka, Kiyoshi Asai, Daisuke Suzuki, Naho Takahashi, et al. Development of PCR Primer Enabling the Design of Flexible Sticky Ends for Efficient Concatenation of Long DNA Fragments. RSC Chemical Biology. 2024. 5. 4. 360-371
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MISC (57)：
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Patents (6)：
  • シクロペンテン誘導体及びシクロペンテン誘導体の製造方法
  • 5'-ホスフィチル化モノマーおよびH-ホスホネートオリゴヌクレオチド誘導体の製造方法
  • 糖1-ボラノホスフェート化合物の立体選択的製造方法
  • 糖1-リン酸化合物の製造方法
  • 糖ボラノホスフェート化合物及びその用途
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Books (1)：
  • 複合糖質の化学と最新応用技術 第3章 糖-1-リン酸誘導体の化学合成
    2009
Lectures and oral presentations  (8)：
  • Stereocontrolled synthesis of P-chiral oligonucleotides for therapeutic applications
    (International Graduate Student Conference on Pharmaceutical Sciences (IGSCPS) 2024 2024)
  • 創薬への応用を志向したリン原子修飾核酸の立体選択的合成
    (第2回東海地区創薬デザイン研究会 2023)
  • Stereocontrolled synthesis of P-chiral oligonucleotide analogs for therapeutic applications
    (IKM Organic & Biomolecular Chemistry Seminar Series 2023 2023)
  • Stereoselective furanosylation reactions for the synthesis of oligosaccharides and nucleosides
    (The 8th International Conference of The Indonesian Chemical Society (ICICS) 2019 2019)
  • Stereocontrolled Synthesis of P-Chiral Oligonucleotides
    (International Symposium on Pure & Applied Chemistry 2017 (ISPAC 2017) 2017)
ｍore...
Education (4)：
  • 2000 - 2003 The University of Tokyo Graduate School of Engineering Department of Chemistry and Biotechnology
  • 1998 - 2000 The University of Tokyo Graduate School of Engineering Department of Chemistry and Biotechnology
  • 1996 - 1998 The University of Tokyo The Faculty of Engineering Department of Chemistry and Biotechnology
  • 1994 - 1996 The University of Tokyo
Professional career (3)：
  • Ph.D. (The University of Tokyo)
  • M.S. (The University of Tokyo)
  • B.S. (The University of Tokyo)
Work history (14)：
  • 2024/10 - 現在 Gifu University Institute for Advanced Study, Gu Composites Center Professor
  • 2024/10 - 現在 Gifu University Institute for Advanced Study, Artificial Intelligence Advanced Research Center Professor
  • 2024/10 - 現在 Gifu University Institute for Advanced Study, Center for One Medicine Innovative Translational Research Professor
  • 2023/04 - 現在 Gifu University Faculty of Engineering, Department of Chemistry and Biomolecular Science Professor
  • 2023/01 - 現在 Institute for Advanced Study, Center for One Medicine Innovative Translational Research, Gifu University Division of innovative modality development
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Committee career (9)：
  • 2024/03 - 現在 有機合成化学協会東海支部 幹事
  • 2023/07 - 現在 Nucleic Acids Therapeutics Society of Japan Councilor
  • 2017/11 - 現在 日本プロセス化学会 東海地区フォーラム幹事
  • 2022/07 - 2023/07 Nucleic Acids Therapeutics Society of Japan Natsj8, Symposium for Young Researchers, organizer
  • 2022/07 - 2023/07 Nucleic Acids Therapeutics Society of Japan 8th Annual Meeting of the Nucleic Acids Therapeutics Society of Japan, organizing committee member
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Awards (2)：
  • 2013 - Ajinomoto Award in Synthetic Organic Chemistry, Japan
  • 2011 - Incentive Award for Young Scientist, Tokai branch of The Society of Synthetic Organic Chemistry, Japan
Association Membership(s) (9)：
The Society of Silicon ChemistryJAPAN ,  The Japanese Peptide Society ,  The Society of Synthetic Organic Chemistry, Japan ,  The Chemical Society of Japan ,  THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH ,  Japan Society of Nucleic Acids Chemistry ,  日本核酸医薬学会 ,  American Chemical Society ,  The Japan Society for Process Chemisry
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