DAITOKU Hiroaki

ダイトクヒロアキ | DAITOKU Hiroaki

Affiliation and department：
Job title： Assistant Professor

Research keywords (6)：タンパク質の翻訳後修飾 , ヒスチジンメチル化 , アルギニンメチル化 , FOXO1 , 老化 , C. elegans

Research theme for competitive and other funds (11)：

2024 - 2028 細胞外環境におけるタンパク質メチル化酵素の生物学的役割の解明
2020 - 2024 ヒスチジンメチル化酵素METTL9の活性制御機構と生物学的意義の解明
2017 - 2020 Relationship between glucose metabolism and FOXO1 acetylation through acetyl-CoA
2014 - 2017 In vivo analysis of longevity mechanism of transcription factor DAF-16/FOXO
2011 - 2016 Crosstalk of transcriptional status and amino acid metabolism

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Papers (54)：

Kenzo Bamba, Midori Ozawa, Hiroaki Daitoku, Arihiro Kohara. Diverting the food-freezing technology improves the cryopreservation efficiency of induced pluripotent stem cells and derived neurospheres. Regenerative therapy. 2024. 27. 83-91
Nagaoka, Yoshiyuki, Takeishi, Yukimasa, Miyake, Yuki, Takeda, Kana, Okamura, Kazuhiko, Yao, Yuan, Motomura, Kaori, Daitoku, Hiroaki, Fukamizu, Akiyoshi, Hatta, Mitsutoki. SOX4 reversibly induces phenotypic changes by suppressing the epithelial marker genes in human keratinocytes. Molecular biology reports. 2024. 51. 1. 116
Bamba, Kenzo, Takabe, Kyosuke, Daitoku, Hiroaki, Tanaka, Yoshikazu, Ohtani, Azusa, Ozawa, Midori, Fukamizu, Akiyoshi, Nomura, Nobuhiko, Kohara, Arihiro, Kunoh, Tatsuki. Discrimination of mycoplasma infection using machine learning models trained on autofluorescence signatures of host cells. SENSORS & DIAGNOSTICS. 2023. Epub
Song-Iee Han, Masanori Nakakuki, Yoshimi Nakagawa, Yunong Wang, Masaya Araki, Yuta Yamamoto, Hiroaki Tokiwa, Hiroyuki Takeda, Yuhei Mizunoe, Kaori Motomura, et al. Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids. PNAS nexus. 2023. 2. 11. pgad351
Hayashi, Takahiro, Daitoku, Hiroaki, Uetake, Toru, Kako, Koichiro, Fukamizu, Akiyoshi. Histidine Npai-methylation identified as a new post-translational modification in histone H2A at His-82 and H3 at His-39. The Journal of Biological Chemistry. 2023

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MISC (11)：

坂巻純一, 大徳浩照, 上野勝也, 山形一行, 深水昭吉. BADのアルギニンメチル化はAKTによるそのリン酸化および不活化に拮抗する(Arginine methylation of BAD counteracts its phosphorylation and inactivation by AKT). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010. 83回・33回. 3T9-8
大徳浩照, 山形一行, 高橋悠太, 坂巻純一, 深水昭吉. タンパク質修飾による遺伝子発現制御のクロストークアルギニンメチル化とAkt誘発リン酸化のクロストーク調節(Crosstalk regulation of arginine methylation and Akt-induced phosphorylation). 日本生化学会大会プログラム・講演要旨集. 2009. 82回. 1S11p-2
大徳浩照, 山形一行, 深水昭吉. アルギニンメチル化とリン酸化 PRMT1によるFOXO1活性制御. 内分泌・糖尿病科. 2008. 27. 6. 580-584
深水昭吉, 山形一行, 大徳浩照. ストレス応答と転写因子フォークヘッド転写因子FOXOファミリーのアルギニンメチル化と酸化ストレス制御(Regulation of Foxo family by arginine methylation in response to oxidative stress). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2008. 81回・31回. 4S19-1
大徳浩照, 山形一行, 深水昭吉. アルギニンメチル化による転写因子FOXO1のリン酸化阻害機構の解明. 日本内分泌学会雑誌. 2008. 84. 2. 697-697

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Books (9)：

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Lectures and oral presentations (123)：

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Education (2)：

1998 - 2003 University of Tsukuba Graduate School, Division of Agriculture Applied Biochemistry
1994 - 1998 University of Tsukuba Second Cluster of College Agrobiological Resources

Professional career (1)：

Work history (4)：

Awards (2)：

Association Membership(s) (2)：

The Molecular Biology Society of Japan , THE JAPANESE BIOCHEMICAL SOCIETY

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