Rchr
J-GLOBAL ID：200901050438500281
Update date: Nov. 17, 2024
Tsukuba Takayuki
ツクバ タカユキ | Tsukuba Takayuki
Affiliation and department：
Job title：
Professor
Research field (3)：
Cell biology
, Oral medicine
, Oral medicine (pathology)
Research keywords (5)：
細胞生物学
, メンブレントラフィック
, Large Rab GTPases
, エンドソーム・リソソーム システム
, endosome /lysosome system
Research theme for competitive and other funds (53)：
- 2024 - 2027 小胞輸送系分子を基軸とする関節リウマチモデルマウスの病態解明
- 2024 - 2027 新規Rabタンパク質機能に着目した歯周疾患発症と病態形成の解析
- 2024 - 2027 Imaging analysis of the dynamics of lysosomal membranes involved in the acidic environment of oral cancer cells
- 2023 - 2026 Development of multifunctional soft denture liners with self-cleaning function and drug delivery function for sustained release of physiologically active substances
- 2023 - 2026 変異型Rufy4を発現する破骨細胞の細胞外小胞を介した骨吸収調節機構の解明と応用
- 2023 - 2026 Functional analysis of a novel membrane transport factor in metabolic bone diseases
- 2021 - 2024 歯周病発症における新規小胞輸送因子の分子機構の解析
- 2021 - 2024 Multimodal imaging analysis of oral cancer cells focused on lysosomes
- 2020 - 2023 Development of multifunctional viscoelastic soft denture liners with controlled release ability of biologically active agent and photocatalyst function using nanocomposites
- 2020 - 2023 Functional and pathological analyses of inflammatory bone destruction disease by a novel Rab protein
- 2019 - 2022 酸化ストレスと骨吸収に関連した新規オートファジー制御因子の機能解明
- 2019 - 2022 破骨細胞における新規輸送因子の同定と機能解明
- 2019 - 2022 Function of a novel Rab protein in neutrophils and its role in periodontal disease
- 2018 - 2021 Regulatory mechanism of mast cell degranulation by the novel Rab protein
- 2017 - 2020 光触媒機能と治癒促進機能をもつダイナミック印象応用型光重合軟質リライン材の開発
- 2017 - 2020 Discovery of a novel gene regulating membrane trafficking of immune cells and elucidation of its pathology
- 2016 - 2019 Molecular mechanism of bone destruction in rheumatoid arthritis based on CD147
- 2016 - 2019 Elucidation of Keap1/Nrf2-mediated control system of bone metabolism and application to in silico drug discovery
- 2016 - 2019 Development of Supplement having anti-cancer action based on Flavonoid
- 2016 - 2018 破骨細胞におけるリソソーム分泌機構の制御因子の同定と分子メカニズムの解析
- 2016 - 2018 Analyses using bioimaging of invasion and colonization mechanisms by periodontal bacteria in the liver
- 2015 - 2018 Elucidation of chronic inflammation exacerbation mechanism due to breakdown of endo-lysosomal proteolysis
- 2015 - 2018 Examination of new medicine for bone metabolism by investigation of potential natural drugs in China
- 2014 - 2017 Development of a multi-function soft denture liner having bFGF-controlled release and self-cleaning functions
- 2014 - 2016 Development of detection systems for polyphenols that inhibit osteoclast formation and its applications
- 2013 - 2016 Elucidation of molecular mechanisms of Nrf2-mediated osteoclastogenesis and search of natural products as molecular targets
- 2013 - 2016 Analysis of new functions of an intracellular protease in epithelial cancers
- 2013 - 2016 Elucidation of the mechanism of systemic diseases by a periodontal pathogen in the intracellular transport
- 2012 - 2015 Cell biological analysis of membrane protein induced by glucocorticoid
- 2012 - 2015 Phylogenetic and biochemical approach for identifying the chronic proinflammatory proteins accumulated in protease-deficient species and individuals
- 2012 - 2014 Mechanistic analysis of periodontal bacteria attached on cardiovascular tissues by live-imaging
- 2010 - 2012 Elucidation of molecular mechanisms of osteoclastogenesis by iron
- 2010 - 2012 Pathological analysis of epithelial cells in periodontitis
- 2009 - 2011 The role of cathepsin E in osteoclast and the research for substrate molecule binding with cathepsin E
- 2007 - 2011 歯周病発症におけるオートファジー機能の解明と治療への応用
- 2008 - 2010 Role(s) of pepstatin A-sensitive aspartic proteinases in osteoclast differentiation
- 2007 - 2009 Protease-mediated regulation of host immune system and application as therapeutic targets
- 2007 - 2008 Experimental analysis of the correlation between periodontal disease and insulin resistance
- 2006 - 2007 上皮細胞におけるエンド・リソソーム性プロテアーゼの機能に関する研究
- 2004 - 2005 Examination of biological response to Porphyromonas gingivalis infection.
- 2004 - 2005 生体防御系におけるプロテアーゼの機能解析
- 2003 - 2005 Molecular basis of host immune responses to periodontal disease
- 2001 - 2004 ESTABLISHMENT OF A CLINICAL TREATMENT SYSTEM FOR PERIODONTAL DISEASE
- 2000 - 2004 神経系におけるオートファジー・リソソームシステム
- 2002 - 2003 歯周病における免疫制御系プロテアーゼの機能解析
- 1999 - 2001 MOLECULAR BASIS OF PROTEINASE FUNCTION IN PROGRESSION OF PERIODONTAL DISEASES
- 1999 - 1999 エンドソーム・リソソーム系蛋白分解機構におけるカテプシンEの役割
- 1996 - 1998 ROLES OF PATHOGENIC PROTEINASES IN PERIODONTAL DISEASE
- 1996 - 1997 カテプシンEの小胞体貯留機構の分子細胞生物学的解析
- 1996 - 1996 細胞内アスパラギン酸プロテアーゼの機能構造形成と細胞機能制御
- 1995 - 1995 破骨細胞におけるカテプシンEの局在と機能
- 1995 - 1995 歯科用金属材料の耐食性と細胞毒性の相関
- 歯周病におけるカテプシンCの機能解析
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Papers (113)：
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Yu Yamaguchi, Tomoko Kadowaki, Eiko Sakai, Mayuko Noguromi, Shun Oyakawa, Takayuki Tsukuba. Impaired Development of Collagen Antibody-Induced Arthritis in Rab44-Deficient Mice. Biomedicines. 2024. 12. 11. 2504-2504
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Kaung Htike, Kunihiro Yoshida, Takanori Eguchi, Katsuki Takebe, Xueming Li, Yaxin Qu, Eiko Sakai, Takayuki Tsukuba, Kuniaki Okamoto. Herbal medicine Ninjinyoeito inhibits RANKL-induced osteoclast differentiation and bone resorption activity by regulating NF-kB and MAPK pathway. Journal of Oral Biosciences. 2024
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Keiko Sato, Tomoko Kadowaki, Mamoru Takenaka, Mayo Konishi, Miyabi Ando, Takae Onodera, Takayuki Tsukuba. RASEF/Rab45 regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2024. 1870. 7. 167310-167310
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Ayuko Tanimoto, Yu Yamaguchi, Tomoko Kadowaki, Eiko Sakai, Shun Oyakawa, Yusuke Ono, Noriaki Yoshida, Takayuki Tsukuba. Rab44 negatively regulates myoblast differentiation by controlling fusogenic protein transport and mTORC1 signaling. Journal of Cellular Biochemistry. 2023
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Shun Oyakawa, Yu Yamaguchi, Tomoko Kadowaki, Eiko Sakai, Mayuko Noguromi, Ayuko Tanimoto, Yusuke Ono, Hiroshi Murata, Takayuki Tsukuba. Rab44 deficiency accelerates recovery from muscle damage by regulating mTORC1 signaling and transport of fusogenic regulators. Journal of Cellular Physiology. 2023
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MISC (82)：
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上野幹憲, 山口優, 吉田朝美, 平坂勝也, 高橋夏美, 門脇知子, 筑波隆幸, 山口健一. マダイ筋肉由来培養細胞株の樹立. 日本水産学会大会講演要旨集(CD-ROM). 2024. 2024
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谷本あゆ子, 山口優, 門脇知子, 坂井詠子, 親川駿, 筑波隆幸. Rab44はmTORC1シグナルを制御することで筋芽細胞の分化を負に制御する. Journal of Oral Biosciences Supplement (Web). 2023. 2023
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野黒美麻由子, 野黒美麻由子, 山口優, 佐藤啓子, 親川駿, 筑波隆幸, 門脇知子. Rab44欠損はニッケルアレルギーに対して減弱した免疫反応を惹起する. Journal of Oral Biosciences Supplement (Web). 2023. 2023
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親川駿, 山口優, 門脇知子, 坂井詠子, 野黒美麻由子, 野黒美麻由子, 谷本あゆ子, 筑波隆幸. Rab44は,筋衛星細胞におけるmTORC1シグナル伝達と融合制御因子の輸送の調節により,筋再生を負に制御する. Journal of Oral Biosciences Supplement (Web). 2023. 2023
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山口優, 門脇知子, 坂井詠子, 野黒美麻由子, 野黒美麻由子, 親川駿, 親川駿, 日浅匠, 日浅匠, 馬渡遥香, et al. Rab44 regulates inflammatory responses in collagen antibody-induced arthritis. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
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Education (4)：
- - 1994 Kyushu University
- - 1994 Kyushu University Graduate School, Division of Dental Research
- - 1990 Nagasaki University School of Dentistry
- - 1990 Nagasaki University Faculty of Dentistry
Work history (4)：
- 2007 - 現在 Nagasaki University Graduate School of Biomedical Sciences
- 2000 - 2007 Kyushu University
- 1994 - 2000 Kyushu University
- 1997 - 1999 The Pennsylvania State University
Committee career (4)：
- 2018 - 現在 歯科基礎医学会 理事
- 1990/04 - 現在 日本生化学会 正会員
- 2000 - 日本病態プロテアーゼ学会 評議員
- 2000 - 日本薬理学会 評議員
Association Membership(s) (4)：
日本生化学会
, 日本病態プロテアーゼ学会
, 歯科基礎医学会
, 日本薬理学会
