SHIMANO Hitoshi

2016 - 2020 Analysis of metabolic diseases targeting nutrient complex associated inflammation caused from enterohepatic circulation

2015 - 2018 The molecular mechanism of organ metabolic disease state and abnormal brain function caused by Elovl6-mediated qualitative changes of fatty acids

2015 - 2017 Molecular mechanism of autophagic abnormality in mouse model with rhabdomyolysis

2014 - 2017 Crucial role for Elovl6 during bone development in mice

2014 - 2017 A Common Genetic Variant of the Chromogranin A-derived peptide Catestatin is Associated with Atherogenesis and Hypertension in a Japanese Population

2013 - 2016 Genetic testing of Pheochromocytoma in Japan

2013 - 2016 Fasting-induced transcription factor CREBH ameliorates obesity via entero-hepatic circulation

2014 - 2015 Anti-atherosclerotic properties of radical-containing nanoparticle

2013 - 2015 脂肪酸伸長酵素Elovl6欠損マウスにおけるショ糖嗜好性亢進機序の解明

2012 - 2015 Study for tissue specific change of lipid quality and metabolism by fatty acid elongase Elovl6

2012 - 2014 An Empirical Study on the clinical application of vital sensor to be used in telenursing

2011 - 2013 The effects to suppress SREBP-1 gene as a lipid synthetic transcription factor on atheroscrelotic model mice.

2011 - 2013 Role of SREBP-1 on the development of hypertesive heart disease

2011 - 2012 Role of fatty acid elongase Elovl6 in the sucrose preference formation

2011 - 2012 The search for elucidating the contribution of chronic inflammation to the development of heart failure and for new treatment

2010 - 2012 The molecular mechanism that CREBH activation by nutrition improves metabolic syndrome

2010 - 2012 Development of a telenursing system for clinical application

2011 - 2011 Evaluation of new nanotechnology to raise HDL cholesterol level and elucidation of its molecular mechanism

2010 - 2011 脂肪酸の質の違いによる自然炎症制御機構の解明

2009 - 2011 Research of SDHB as Malignant marker and oncogenesis in malignant pheochromocytomas

2009 - 2011 Control of energy metabolism by changes of the organ lipid quality through fatty acid elongase Elovl6.

2010 - 2010 肝臓の脂肪酸組成変化による新規血清LDLコレステロール制御機構の解明

2008 - 2010 Investigation for suppressing function of the transcription factor SREBP-1, to develop therapeutic approach to Metabolic Syndrome.

2008 - 2009 脂質合成系調節転写因子SREBP-1/2の標的配列特異性を決定する共因子の解明

2008 - 2008 新規膜結合型転写因子CREB-Hのエネルギー代謝調節メカニズム

2007 - 2008 Analysis of the pleiotropic effects of TFE3 on metabolic syndrome

2005 - 2008 Molecular mechanisms of biliary and pancreatic development

2007 - 2007 SREBP2過剰発現マウスによるコレステロール代謝とインスリン分泌の関連の検討

2006 - 2007 Transcriptional regulation of energy metabolism in metabolic syndrome.

2006 - 2007 CDKインヒビターp21の脂肪細胞分化、肥大化における役割の検討

2005 - 2006 Study on a novel energy metabolism transcription factor that regulates insulin signaling

2005 - 2005 脂質合成転写因子の細胞増殖、細胞周期にもたらす影響に関する検討

2004 - 2005 腫瘍抑制因子p53活性化によるインスリン抵抗性発症の新しい分子機構の解明

2004 - 2005 The effects of partial disruption of tricarboxylic acid cycle on energy metabolism. The analysis of expression forms of citrate synthetase gene-disrupted mice

2004 - 2005 Animal model for metabolic syndrome and its molecular basis.

2003 - 2004 Liver atrophy and Lipid metabolism after mesocaval and portocaval shunt in the rats

2003 - 2004 The study of regulation of rat insulin promoter I by lipid synthetic transcription factors, SREBPs

2003 - 2003 遺伝子改変マウスを用いた新規脂肪酸組成調節酵素のエネルギー代謝に及ぼす影響の検討

2002 - 2003 The effects of targeted disruption of a gene encoding rate-limiting enzyme of the TCA Cycle on mice

2002 - 2002 骨髄移植によるインスリン抵抗性および肥満治療の試みと脂肪幹細胞の単離

2002 - 2002 糖尿病性血管合併症の発症に関わる細胞外分泌タンパク遺伝子の同定

2001 - 2002 Studies on a model animal for atherogenic lipoproteins and atherosclerosis

2001 - 2002 Regulation of signaling pathway, cell cycle, and cell growth in atherosclerosis

2001 - 2001 糖尿病性血管合併症に特異的な遺伝子マーカーの分離同定

2000 - 2001 New therapeutic targets for atherosclerotic plaques - The role of acyl CoA : cholesterol acyltransferase and neutral cholesterol ester hydrolase in foam cell formation

2001 - Transcriptional regulation of energy metabolism

2001 - cross network of SREBP and other factors

2000 - 2000 病態モデル動物を用いた動脈硬化及びインスリン抵抗性遺伝子マップの作成

1999 - 2000 Transgenic study on the heterogeneity of intacellular triacylglycerol lipase

1993 - 1995 Establishment of animal models for atheroscherosis and gene therapy

1993 - 1993 アポリポ蛋白Eのトランスジェニックマウスの開発と応用

1992 - 1992 LPLおよびLCAT遺伝子変異に基く高脂血症,低HDL血症の発症メカニズム

Study on Transcriptional Regutation of Energy Metabolism

Gene Regulation involved in Atherosclerosis

Molecular Mechanism of Obesity and Insulin Resistance

A novel strategy against life-related diseases in the light of fatty acids quality aspect of fatty acids