Rchr
J-GLOBAL ID：200901050560064662
Update date: Jul. 17, 2024
JUNICHI MATSUMOTO
マツモト ジュンイチ | JUNICHI MATSUMOTO
Affiliation and department：
Research field (2)：
Clinical pharmacy
, Pharmacology
Research keywords (3)：
Chronic Obstructive Pulmonary Disease
, エクソソーム
, 血液脳関門
Research theme for competitive and other funds (11)：
- 2024 - 2027 慢性閉塞性肺疾患COPD併存うつ病の治療薬による原疾患増悪ジレンマのメカニズム
- 2022 - 2025 アンドロゲンシグナルから捉えるCOPD病態の解析と治療薬の探索
- 2021 - 2024 アンドロゲンを核とする内分泌系-肺-脳の臓器連関異常化によるCOPD病態増悪機構
- 2021 - 2024 Invovlvement of increased vascular permeability in bortezomib-induced lung toxicity
- 2019 - 2022 Involvement of activated brain pericytes induced by inflammatory bowel disease in the increased aggregation of alpha-synuclein in the brain.
- 2019 - 2022 Decreased expression of OATP2a1 in porcine pancreas elastase-induced COPD mouse model.
- 2014 - 2018 A key role of the brain pericytes in the induction and development of brain inflammation under the pathophysiological conditions of obesity-associated diabetes.
- 2015 - 2016 生活習慣病に起因する腸内細菌叢の変調・異常と脳内β-amyloid動態障害の解明
- 2012 - 2015 慢性閉塞性肺疾患の血液脳関門病変化とレニン・アンジオテンシン系阻害薬の保護作用
- 2011 - 2013 Involvement of pericytes-derived cyclophilin A in the development of insulin resistanse in the brain
- 2009 - 2010 Involvement of brain pericytes in the development of obesity
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Papers (34)：
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Kentaro Aono, Junichi Matsumoto, Taichi Matsumoto, Mitsuhisa Koga, Keisuke Migita, Koji Tominaga, Shinsuke Nakagawa, Atsushi Yamauchi. Association of T cell infiltration and morphological change of thymus gland with the aggravation of pulmonary emphysema in testosterone deficiency. Biochemistry and biophysics reports. 2023. 34. 101489-101489
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Taichi Matsumoto, Junichi Matsumoto, Yuka Matsushita, Moeno Arimura, Kentaro Aono, Mikiko Aoki, Kazuki Terada, Masayoshi Mori, Yutaka Haramaki, Takuya Imatoh, et al. Bortezomib Increased Vascular Permeability by Decreasing Cell-Cell Junction Molecules in Human Pulmonary Microvascular Endothelial Cells. International journal of molecular sciences. 2023. 24. 13
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Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Yuki Goto, Hisataka Aridome, Miho Yasunaga, Miki Yokoya, Yasufumi Kataoka, Shinya Dohgu. Senescence in brain pericytes attenuates blood-brain barrier function in vitro: A comparison of serially passaged and isolated pericytes from aged rat brains. Biochemical and biophysical research communications. 2023. 645. 154-163
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Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Hisataka Aridome, Miho Yasunaga, Miki Yokoya, Yasufumi Kataoka, Shinya Dohgu. Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice. PloS one. 2023. 18. 2. e0281946
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Taira Matsuo, Rie Komori, Minami Nakatani, Shiori Ochi, Aya Yokota-Nakatsuma, Junichi Matsumoto, Fuyuko Takata, Shinya Dohgu, Yasuhiro Ishihara, Kouichi Itoh. Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice. International journal of molecular sciences. 2022. 23. 14
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MISC (19)：
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冨永 宏治, 青野 健太郎, 松本 純一, 古賀 允久, 山内 淳史, 江川 孝, 片岡 泰文. COPDモデルマウスにおけるリポキシンA4に対するエストロゲンの影響. 日本薬学会年会要旨集. 2020. 140年会. 26Q-pm097
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Ikuya Kimura, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Atsushi Yamauchi, Yasufumi Kataoka. Nicotinic acetylcholine receptors modulate TNF-alpha-induced MMP-9 release from brain pericytes. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 209P-209P
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Makoto Shougakiuchi, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Yui Yamamoto, Haruka Aikawa, Satomi Nagata, Shinya Dohgu, Yasufumi Kataoka. Adenosine stimulates brain pericytes to release matrix metalloproteinase-9 through A3 adenosine receptor. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 215P-215P
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Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Hiroyuki Takahashi, Atsushi Yamauchi, Yasufumi Kataoka. Brain pericyte-derived soluble factors induce the blood-brain barrier dysfunction under pathological conditions. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 25P-25P
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Ikuya Kimura, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Atsushi Noriyuki, Atsushi Yamauchi, Yasufumi Kataoka. Alpha7 nicotinic acetylcholine receptor mediates MMP-9 release from brain pericytes. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 215P-215P
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Lectures and oral presentations (21)：
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精巣摘出によるテストステロン欠乏はPPE誘発の肺気腫形成を加速させる
(日本薬学会第141年会 2021)
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テストステロン補充は精巣摘出マウスにおけるPPE誘発の肺気腫形成を抑制する
(日本薬学会第141年会 2021)
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ボルテゾミブはタイトジャンクションの破綻を介して血管透過性を亢進する
(日本薬学会第141年会 2021)
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加熱式たばこPloom TECH抽出物による血液脳関門障害
(日本薬学会第141年会 2021)
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シクロスポリンによる脳ペリサイトのαシヌクレインオリゴマー分解促進
(第94回日本薬理学会年会 2021)
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Professional career (1)：
Work history (3)：
- 2017/10/01 - Fukuoka University Faculty of Pharmaceutical Sciences Research Associate
- 2015/09/01 - 2017/08/31 University of Washington Postdoctoral Researcher
- 2009/04/01 - 2015/08/31 Fukuoka university Faculty of Pharmaceutical Sciences Research associate
Association Membership(s) (2)：
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