Yoshiba Nagako

ヨシバナガコ | Yoshiba Nagako

Affiliation and department：

Research field (1)： Conservative dentistry and endodontics

Research theme for competitive and other funds (33)：

2024 - 2026 マクロファージの表現型に影響する細胞外基質ラミニンの機能解析
2022 - 2026 Functional analysis of extracellular matrix laminin affecting macrophage phenotype
2021 - 2024 歯髄の創傷治癒・再生過程におけるGli1陽性幹細胞の動態と分化誘導機構の解明
2019 - 2022 ヒト歯髄の創傷治癒過程におけるM2マクロファージとシュワン細胞の相互作用の解明
2021 - 2022 シュワン細胞がマクロファージを神経保護作用を有する表現型に誘導する機序の解明

2019 - 2020 The clarification of the pulp generation mechanism to improve the odontoblast differentiation by the transporter of ascorbic acid.

2016 - 2020 A study on the mechanisms of induction and differentiation of stem cells during wound healing and regeneration of dentin-pulp complex

2016 - 2019 Role of alpha-SMA expressing cells in dental pulp wound healing and regeneration

2014 - 2017 Regeneration of rat molar pulp tissue by the implantation of stem cells from incisor pulp: development of a rat model of autologous pulp tissue engineering

2013 - 2016 Contribution of Myofibroblasts in Dental Pulp Healing and Regeneration

2013 - 2015 Application of activated macrophages derived from dental pulp stem cells to dental pulp tissue engineering

2012 - 2015 A study on the mechanisms of tissue wound healing and regeneration of dental pulp

2011 - 2014 Dental pulp regeneration by stem cell transplantation: development of scaffolds and establishment of an animal experimental model

2011 - 2012 Elucidation of the mechanism of post-repantation replacement resorption as a basis for the development of periodontal ligament regeneration therapy

2010 - 2012 Degradation and down-regulation of fibrillin-1 during wound healing of human dental pulp tissue

2009 - 2011 A study on the mechanisms of tissue repair and regeneration of dentin-pulp complex

2008 - 2010 Pathogenic mechanisms in apical periodontitis : innate immunity, acquired immunity and dendritic cell maturation

2007 - 2009 A study of pulpal responses to laser irradiation

2007 - 2008 歯内歯周疾患の病態形成機序-新規疾患モデルを用いた樹状細胞の動態解析

2006 - 2008 A study on mechanisms of tissue repair and regeneration of the dentin-pulp complex

2005 - 2007 Immune defense mechanisms of the dentin/pulp complex: Immunohistochemical analysis on the heterogeneity and kinetics of dendritic cells

2004 - 2006 Evaluation of pulpal responses to GaAIAs laser irradiation.

2004 - 2005 A study on mechanisms of tissue formation and regeneration of the dentin-pulp complex

2002 - 2003 A study on mechanisms of tissue repair and regeneration of the dentin-pulp complex

2001 - 2002 う蝕修復処置後の歯髄反応に関する免疫組織化学的研究

1998 - 2000 A study on mechanisms of odontoblast differentiation during reparative dentinogenesis.

1998 - 1999 生体親和性歯髄保護材の開発に関する基礎的研究

歯牙形成における上皮-間葉相互作用に関する研究

歯牙形成ならびに被蓋硬組織(dentin bridge)形成に関する研究

生体親和性材料に対する歯髄反応に関する研究

Epithelial-mesenchymal interactions during tooth development

Study on tooth development and dentin bridge formation

Study on Pulpal Response to Biomaterials

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Papers (79)：

枝並直樹, 高原信太郎, 大倉直人, 吉羽邦彦, 吉羽永子, 野杁由一郎. 断髄後の創面における異栄養性石灰化と非コラーゲン性タンパク質の集積. 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集. 2024. 160回. 90-90
Kridtapat Sirisereephap, Hikaru Tamura, Jong-Hyung Lim, Meircurius Dwi Condro Surboyo, Toshihito Isono, Takumi Hiyoshi, Andrea L. Rosenkranz, Yurie Sato-Yamada, Hisanori Domon, Akari Ikeda, et al. A novel macrolide-Del-1 axis to regenerate bone in old age. iScience. 2024. 27. 2. 108798-108798
高原信太郎, 大倉直人, 吉羽永子, 竹中彰治, 枝並直樹, 吉羽邦彦, 野杁由一郎. 再生歯内療法後の治癒過程初期における各種間葉系幹細胞マーカー陽性細胞の局在性. 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集. 2023. 159回. 47-47
大倉直人, 吉羽永子, 高原信太郎, Baldeon Gutierrez Rosa Edith, Gomez-Kasimoto Susan, 井田貴子, 枝並直樹, 竹中彰治, 吉羽邦彦, 野杁由一郎. 歯根形成時におけるTissue nonspecific alkaline phosphataseの機能解析. 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集. 2023. 159回. 92-92
高原信太郎, 大倉直人, 吉羽邦彦, 吉羽永子, 竹中彰治, 枝並直樹, 庭野和明, 野杁由一郎. 歯髄再生療法モデルラットを用いた歯根成長段階による治癒形態の比較解析. 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集. 2023. 158回. 31-31

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MISC (104)：

高原信太郎, 大倉直人, 吉羽邦彦, 吉羽永子, 竹中彰治, 枝並直樹, 庭野和明, 野杁由一郎. The comparison analyses of wound-healing mechanism according to the root development stage using the regeneration model rats. 日本歯科保存学会学術大会プログラムおよび講演抄録集(Web). 2023. 158th
高原信太郎, 大倉直人, 吉羽永子, 竹中彰治, 枝並直樹, 吉羽邦彦, 野杁由一郎. The localization of various mesenchymal stem cell marker-positive cells in early healing stage after regenerative endodontic procedure. 日本歯科保存学会学術大会プログラムおよび講演抄録集(Web). 2023. 159th
大倉直人, 大倉直人, 吉羽永子, 高原信太郎, GUTIERREZ Rosa Edith Baldeon, GOMEZ-KASIMOTO Susan, 井田貴子, 枝並直樹, 竹中彰治, 吉羽邦彦, et al. Impact of the tissue nonspecific alkaline phosphatase during the root formation. 日本歯科保存学会学術大会プログラムおよび講演抄録集(Web). 2023. 159th
高原信太郎, 枝並直樹, 竹中彰治, 吉羽邦彦, 大倉直人, 吉羽永子, 野杁由一郎. Interactions between Apically-extruded Bioceramic Sealers and periodontal tissues. 日本歯科保存学会学術大会プログラムおよび講演抄録集(Web). 2022. 157th
枝並直樹, 竹中彰治, 吉羽邦彦, 大倉直人, 吉羽永子, 高原信太郎, 野杁由一郎. Comparison of Biomineralization Ability of Calcium Silicate-based and Calcium Hydroxide-based Intracanal Medicaments. 日本歯科保存学会学術大会プログラムおよび講演抄録集(Web). 2022. 157th

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Books (6)：

Distribution of noncollagenous proteins during reparative dentinogenesis in human teeth.
Dentin/Pulp Comples:Proceeding of the International Conference on Dentin/Pulp Complex 2001. 2002
Distribution of concollagenous proteins during reparative dentinogensis in human teeth.
Dentin/Pulp Comples:Proceeding of the International Conference on Dentin/Pulp Complex 2001. 2002
Distribution of the small proteoglycan decorin in human teeth. (共著)
Dentin/Pulp Complex : Proceedings of the International Conference on Dentin/Pulp Complex 1995. Quintessence Publishing Co. 1996
Distribution of odontoblast processes in human coronal dentin. (共著)
Dentin/Pulp Complex : Proceedings of the International Confernce on Dentin/Pulp Complex 1995. Quintessence Publishing Co. 1996
Hard tissue formation in subcutaneously transplanted rat molars.
Dentin/Pulp Complex:Proceeding of the International Conference on Dentin/Pulp Complex 2001. Quintessence Publishing Co.

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Education (2)：

- 1989 Niigata University Faculty of Dentistry School of Dentistry
- 1989 Niigata University Faculty of Dentistry

Professional career (1)：

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Work history (9)：

2024/04 - 現在新潟大学大学院医歯学総合研究科口腔保健学分野教授
2022/11 - 2024/03 Niigata University
2009/04 - 2024/03 新潟大学医歯学総合病院講師
2021/04 - 2022/03 2021年度拠点事業「大阪大学蛋白質研究所共同研究員」
2000/01 - 2009/03 新潟大学歯学部助手

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Awards (4)：

2021/12 - 新潟大学令和3年度新潟大学優秀論文賞
2014 - 日本歯科保存学会学術賞
1998 - 日本歯科保存学会奨励賞
1995 - 財団法人山下太郎海外派遣助成賞

Association Membership(s) (5)：

日本結合組織学会 , ORCA , 新潟歯学会 , 日本歯科保存学会 , 歯科基礎医学会

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