Hirabayashi Tetsuya

ヒラバヤシテツヤ | Hirabayashi Tetsuya

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/ja/r/90345025

Research field (3)： Molecular biology , Neuroscience - general , Cell biology

Research keywords (12)：アシルセラミド , 皮膚バリア , ホスホリパーゼA2 , リゾホスホリパーゼ , 魚鱗癬 , 神経変性疾患 , 肝疾患 , コリン , GPC , Metabolomics , セラミド , 脂質代謝

Research theme for competitive and other funds (17)：

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Papers (42)：

Hitomi Karyu, Takahiro Niki, Yuriko Sorimachi, Shoji Hata, Shiho Shimabukuro-Demoto, Tetsuya Hirabayashi, Kojiro Mukai, Kohji Kasahara, Keiyo Takubo, Nobuhito Goda, et al. Collaboration between a cis-interacting natural killer cell receptor and membrane sphingolipid is critical for the phagocyte function. Frontiers in Immunology. 2024. 15
Keisuke Komatsuya, Masaki Ishikawa, Norihito Kikuchi, Tetsuya Hirabayashi, Ryo Taguchi, Naomasa Yamamoto, Morio Arai, Kohji Kasahara. Integrin-Dependent Transient Density Increase in Detergent-Resistant Membrane Rafts in Platelets Activated by Thrombin. Biomedicines. 2023. 12. 1. 69-69
Keisuke Komatsuya, Norihito Kikuchi, Tetsuya Hirabayashi, Kohji Kasahara. The Regulatory Roles of Cerebellar Glycosphingolipid Microdomains/Lipid Rafts. International journal of molecular sciences. 2023. 24. 6
Sayaka Harada, Yoshitaka Taketomi, Toshiki Aiba, Mai Kawaguchi, Tetsuya Hirabayashi, Baasanjav Uranbileg, Makoto Kurano, Yutaka Yatomi, Makoto Murakami. The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism. Biomolecules. 2023. 13. 3
Tetsuya Hirabayashi, Mai Kawaguchi, Sayaka Harada, Misa Mouri, Rina Takamiya, Yoshimi Miki, Hiroyasu Sato, Yoshitaka Taketomi, Kohei Yokoyama, Tetsuyuki Kobayashi, et al. Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups. Cell reports. 2023. 42. 2. 111940-111940

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MISC (45)：

平林哲也, 村上誠. 【治療標的がみえてきた脂質疾患学がん、不妊症、免疫・神経・皮膚・代謝性疾患のメカニズムから臨床検体による診断、層別化まで】(第3章)脂質と多彩な疾患の深い関係肥満・代謝性疾患肝疾患におけるPNPLAファミリーの役割. 実験医学. 2023. 41. 17. 2860-2867
東鷹美, 武富芳隆, 住田準一, 池田和貴, 七野成乃, 佐藤伸一, 松島綱治, 平林哲也, 村上誠. 皮膚の線維化を抑制する新規脂質代謝酵素の同定. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1T03a-048)]
川口舞, 平林哲也, 笠原浩二, 村上誠. 中枢神経系のリゾホスホリパーゼ欠損による重度の神経原性筋萎縮. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1T16a-625)]
平林哲也, 村上誠. 肝臓の細胞膜から重要な栄養素コリンを取り出す仕組み. ファルマシア. 2023. 59. 8. 725-729
川口舞, 平林哲也, 笠原浩二, 村上誠. 中枢神経系のリゾホスホリパーゼ欠損は神経原性筋萎縮を引き起こす. 脂質生化学研究. 2023. 65. 111-114

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Patents (2)：

Lectures and oral presentations (5)：

PNPLA8とPNPLA7によるホスファチジルコリンの分解は肝臓のメチル基供給に重要である
(第91回日本生化学会大会 2018)
Phosphatidylcholine catabolism mediated by PNPLAs plays an important role in liver function and energy homeostasis
(2nd Japan-Korea Lipid Joint Symposium 2018)
Phosphatidylcholine catabolism by PNPLA7 provides a source of hepatic methyl groups and controls energy homeostasis
(59th ICBL (International Conference on the Bioscience of Lipids) 2018)
Pnpla7 in the mouse brain regulates choline homeostasis
(Joint Annual Meeting ISMRM-ESMRMB 2018)
PNPLA1 is required for omega-O-acylceramide synthesis and proper keratinicyte differentiation
(58th ICBL (International Conference on the Bioscience of Lipids) 2017)

Professional career (1)：

Work history (5)：

Association Membership(s) (5)：

肝細胞研究会 , セラミド研究会 , THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS , THE JAPANESE BIOCHEMICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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