Rchr
J-GLOBAL ID：200901051146968505   Update date: Dec. 05, 2024

Shibata Atsushi

シバタ アツシ | Shibata Atsushi
Affiliation and department：
Keio University

About Keio University


Job title： Professor
Other affiliations (1)：
Homepage URL  (2)： https://shibataxlab.com/ ,  https://shibataxlab.com/english/
Research field  (6)： Environmental effects of chemicals ,  Environmental effects of radiation ,  Radiology ,  Pathobiochemistry ,  Molecular biology ,  Genetics
Research keywords  (14)： DNA修復 ,  DNA損傷 ,  がん治療 ,  化学放射線治療 ,  がん免疫治療(PD-L1, HLA, Neoantigen) ,  クロマチン ,  幹細胞 ,  遺伝子発現調節 ,  ゲノム医科学 ,  ゲノム安定性 ,  発がん ,  創薬・核酸医薬 ,  超高解像度蛍光顕微鏡 ,  蛍光イメージング解析
Research theme for competitive and other funds  (41)：
  • 2023 - 2026 人工ウィルスにより抗腫瘍免疫を起動する新規免疫療法の開発
  • 2022 - 2025 ヒト遺伝子破壊株を用いた高LET線誘発DSBの修復とゲノム情報への影響の解析
  • 2021 - 2025 全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究
  • 2021 - 2023 非自己核酸が誘発するHLA提示およびISGs発現誘導を介した免疫惹起機構の研究
  • 2020 - 2022 遺伝子領域間に引き起こされる転写共役型染色体転座経路の解明
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Papers (105)：
  • Hikaru Okumura, Ryota Hayashi, Daiki Unami, Mayu Isono, Motohiro Yamauchi, Kensuke Otsuka, Yu Kato, Takahiro Oike, Yuki Uchihara, Atsushi Shibata. MeCP2 deficiency leads to the γH2AX nano foci expansion after ionizing radiation. DNA Repair. 2024. 103790-103790
  • Kie Ozaki, Reona Kato, Takaaki Yasuhara, Yuki Uchihara, Miyako Hirakawa, Yu Abe, Hiroki Shibata, Reika Kawabata-Iwakawa, Aizhan Shakayeva, Palina Kot, et al. Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks. Scientific Reports. 2024. 14. 1
  • Shunji Haruna, Ken Okuda, Akiko Shibata, Mayu Isono, Kohei Tateno, Hiro Sato, Takahiro Oike, Yuki Uchihara, Yu Kato, Atsushi Shibata. Characterization of the signal transduction cascade for inflammatory gene expression in fibroblasts with ATM-ATR deficiencies after Ionizing radiation. Radiotherapy and Oncology. 2024. 194. 110198-110198
  • Hidekazu Oyoshi, Junyan Du, Shunsuke A. Sakai, Riu Yamashita, Masayuki Okumura, Atsushi Motegi, Hidehiro Hojo, Masaki Nakamura, Hidenari Hirata, Hironori Sunakawa, et al. Comprehensive single-cell analysis demonstrates radiotherapy-induced infiltration of macrophages expressing immunosuppressive genes into tumor in esophageal squamous cell carcinoma. Science Advances. 2023. 9. 50
  • Yuki Uchihara, Atsushi Shibata. Regulation of DNA damage-induced HLA class I presentation. DNA Repair. 2023. 132. 103590-103590
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MISC (15)：
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Lectures and oral presentations  (60)：
  • RAP80 suppresses deleterious repair of double-strand break in transcribed genome
    (第10回 International Symposium on DNA Damage Response & Human Disease (isDDRHD) 2019)
  • DNA二本鎖切断修復経路の決定メカニズム
    (日本核酸医薬学会生物セッション第4回サテライトシンポジウム 2019)
  • Pursuing High-Quality Radiobiology & Radiation Oncology in Indonesia: from basics - clinics - publication
    (IROS Annual Scientific Meeting 2019)
  • Regulation of DSB repair pathway choice and its downstream signaling
    (第78回日本癌学会学術総会 シンポジウム「発がん微小環境におけるDNA修復欠損の役割」 2019)
  • Regulation of transcription-associated end-joining mediated by MRE11, BRCA1, Polθ and LIG1/3
    (16th International Congress of Radiation Research 2019 2019)
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Education (3)：
  • - 2006 Tokyo Medical and Dental University
  • - 2003 Kyoritsu College of Pharmacy Degree of Pharmaceutical Master
  • - 2001 Kyoritsu College of Pharmacy Faculty of medicine Department Bachelor of Pharmacy
Professional career (1)：
  • Medicine (Tokyo Medical and Dental University)
Work history (9)：
  • 2023/04 - 現在 Keio University Faculty of Pharmacy
  • 2019/04 - 2023/03 群馬大学
  • 2017/04 - 2019/03 Gunma University Education and Research Support Center (ERSC), Graduate School of Medicine
  • 2013 - 2017 Gunma University Advanced Scientific Research Leaders Development Unit
  • 2012 - 2013 University of Sussex JSPS postdoctoral fellowship for Research Abroad
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Awards (6)：
  • 2020/03 - 公益財団法人放射線影響協会 放射線影響研究 奨励賞
  • 2017 - 第24回 DNA複製・組換え・修復ワークショップ 若手発表賞
  • 2017 - 日本放射線影響学会第60回大会 優秀演題発表賞
  • 2017 - 放射線影響学会 奨励賞
  • 2012 - Joint British Association for Cancer Research-Gray Institute Poster prize
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Association Membership(s) (6)：
NAR Cancer (Editorial Board) ,  Frontiers in Aging (Editorial Board) ,  DNA Repair (Editorial Board) ,  日本生化学会 ,  日本抗加齢医学会 ,  日本薬学会
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