Niigata University
Faculty of Dentistry School of Dentistry
Associate Professor
Research field (2)：
Oral medicine (pathology)
, Oral medicine
Research theme for competitive and other funds (64)：
2023 - 2026 Homeostatic maintenance and activation of dental pulp quiescent stem/progenitor cells regulated by dendritic cells and macrophages
2023 - 2026 Homeostatic maintenance and activation of dental pulp quiescent stem/progenitor cells regulated by dendritic cells and macrophages
2021 - 2024 歯の形成過程における糖代謝リプログラミングの制御機構
2020 - 2022 Clarification of the origin and maintenance mechanisms of junctional epithelium and identification of its stem cells using allogenic tooth germ transplantation
2018 - 2021 下顎頭軟骨初期形成を制御する因子の探求
2018 - 2021 Regulatory mechanism of stress-responding glycometabolism in ameloblast differentiation
2017 - 2020 Clarification of the homeostatic mechanism and activation of dental pulp progenitor/quiescent stem cells using proteomic approach
2017 - 2020 Mechanisms maintaining quiescent stem cells by Shh signaling in the apical bud of incisors and developing molars in mice
2015 - 2018 Expression and roles of hyaluronan in tooth germ formation
2014 - 2017 In vivo regulation of chondroitin sulfate gene to recovery from spinal cord injury
2014 - 2017 Elucidation of construction mechanism of extracellular environment around tooth germs via proteoglycan
2015 - 2016 下顎骨の骨粗鬆症診断:組織から画像へのインタープリテーション
2013 - 2016 Subpopulation of dental pulp stem/progenitor cells: Their implication in the differentiation capacity, origin, and microenvironment
2013 - 2016 Involvement of local BDNF after nerve injury in the bone sclerosis change.
2012 - 2015 Elucidation of new function of glycogen - The possibility as accelerating agent for odontogenesis and osteogenesis
2011 - 2015 Development of diagnostic method of osteoporosis using the structural indices of mandibular alveolar bone.
2007 - 2009 Elucidation of the localization and differentiation capacity of dental pulp stem cells
2007 - 2008 The role of perlecan in the oral mucosa and the skin appendage-Transgenic mice overexpression of perlecan-
2006 - 2008 Molecular and pathology analyses for switching mechanism of stromal inducement in invasive oral carcinoma
2005 - 2007 上皮組織における基底膜型ヘパラン硫酸プロテオグリカン・パールカンの役割
2005 - 2006 The role of basement membrane type heparan sulfate proteoglycan, perlecan, in epithelial morphogenesis -transgenic mice overexpressing perlecan in the epithelial cells-
2004 - 2006 Molecular biologic and pathologic analysis of Epstein-Barr virus infection related salivary lymphoepithelial carcinoma
2003 - 2006 Molecular pathological analysis of oral carcinoma caused by chewing habits in Asia
2003 - 2005 胚エナメル器における基底膜型ヘパラン硫酸プロテオグリカン・パールカンの役割
2004 - 2005 Molecular pathological study of mechanism in malignant changes of oral benign tumors
2003 - 2004 Molecular pathological analysis of intraepithelial distribution of extracellular matrix molecules
2002 - 2004 A new anti-cancer strategy by control ling crosstalk of oral carcinoma cells with extracellular matrix molecules
2001 - 2003 歯胚発育障害における基底膜型ヘパラン硫酸プロテオグリカンの役割
2002 - 2003 Molecularbaological study of craniofacial dysmorphology in transgenic mice bearing Apert type mutant Fgfr2 gene
2002 - 2003 Metastasis-associated genes in salivary adenoid cystic carcinoma and oral squamous cell carcinoma : a differential DNA chip analysis between metastatic and non-metastatic cell systems
2001 - 2003 A new anti-cancer strategy by control ling cross talk of oral carcinoma cells with extra cellular matrix molecules
2001 - 2003 Polymorphism in cancer-related genes among oral cancers from the eastern Asian area
2002 - 2002 アジア民族の表在型口腔粘膜癌の発生に関する病理疫学的研究
2001 - 2002 歯胚発育障害における基底膜型ヘパラン硫酸プロテオグリカンの役割
2001 - 2002 口腔粘膜上皮層内に細胞外基質は存在するか
2000 - 2002 Molecular biologic and pathologic study of Epstein-Barr virus infected lymphepithalial carcinomas in salivary gland
2000 - 2001 歯胚発育障害における基底膜型ヘパラン硫酸プロテオグリカンの役割
2000 - 2001 Mutational events of p53 gene in salivary gland tumors
2000 - 2001 Microarray gene expression analysis for development prognostic factors for oral squamous cell carcinoma
2000 - 2000 歯胚発育障害における基底膜型ヘパラン硫酸プロテオグリカンの役割
1999 - 2000 Molecular pathologic study of precancerous lesions of the salivary gland
1998 - 2000 A variety of molecular crosstalks between extracellular matrices and their cell surface receptors in oral carcinomas
1998 - 2000 Anti-oral cancer strategy by means of inhibition of cellular adhesion to extracellula matrices
1999 - 1999 唾液腺多形性腺腫の血管に乏しい間質の分子病理学的特性とCT造影性
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Papers (86)：
Yunosuke Ikeda, Rika Yasuhara, Junichi Tanaka, Hiroko Ida-Yonemochi, Haruhiko Akiyama, Keishi Otsu, Ikuya Miyamoto, Hidemitsu Harada, Hiroyuki Yamada, Toshiyuki Fukada, et al. PLAG1 overexpression in salivary gland duct-acinar units results in epithelial tumors with acinar-like features: Tumorization of luminal stem/progenitor cells may result in the developmen t of salivary gland tumors consisting of only luminal cells. Journal of Oral Biosciences. 2024
Hiroko Ida-Yonemochi, Keishi Otsu, Tarou Irié, Atsushi Ohazama, Hidemitsu Harada, Hayato Ohshima. Loss of autophagy disrupts stemness of ameloblast-lineage cells in aging. Journal of Dental Research. 2024. in press. 220345231209931-220345231209931
Junko Shimomura-Kuroki, Masayuki Tsuneki, Hiroko Ida-Yonemochi, Yuta Seino, Keiko Yamamoto, Yoshitoshi Hirao, Tadashi Yamamoto, Hayato Ohshima. Establishing protein expression profiles involved in tooth development using a proteomic approach. Odontology. 2023
Hiroko Ida-Yonemochi, Kosei Takeuchi, Hayato Ohshima. Role of chondroitin sulfate in the developmental and healing process of the dental pulp in mice. Cell and tissue research. 2022. 388. 1. 133-148
Chihiro Imai, Hiroto Sano, Angela Quispe-Salcedo, Kotaro Saito, Mitsushiro Nakatomi, Hiroko Ida-Yonemochi, Hideyuki Okano, Hayato Ohshima. Exploration of the role of the subodontoblastic layer in odontoblast-like cell differentiation after tooth drilling using Nestin-enhanced green fluorescent protein transgenic mice. Journal of oral biosciences. 2022. 64. 1. 77-84
ANGELA Quispe-Salcedo, ANGELA Quispe-Salcedo, 山崎智彦, 依田浩子, 大島勇人. Effects of synthetic CpG oligodeoxynucleotides on the healing process of heavily injured tooth pulp. 日本再生医療学会総会(Web). 2023. 22nd
2008/09/01 - 現在 Niigata University Faculty of Dentistry School of Dentistry Associate Professor
2008/09/01 - 現在 Niigata University Graduate School of Medical and Dental Sciences Oral Life Science Tissue Regeneration and Reconstruction Associate Professor
2007/09/01 - 2008/08/31 Niigata University University Medical and Dental Hospital Surgical Care Lecturer
Niigata University Graduate School of Medical and Dental Sciences Oral Life Science Tissue Regeneration and Reconstruction Associate Professor
