Rchr
J-GLOBAL ID：200901052146038784   Update date: Aug. 06, 2024

Sawada Junichi

サワダ ジュンイチ | Sawada Junichi
Affiliation and department：
University of Shizuoka Center for Drug Screening

About University of Shizuoka Center for Drug Screening


Job title： Associate Professor
Research field  (3)： Pharmaceuticals - health and biochemistry ,  Molecular biology ,  Molecular biochemistry
Research keywords  (7)： 分子細胞生物学 ,  微小管 ,  分子モーター ,  転写因子 ,  転写制御 ,  阻害剤 ,  細胞周期
Research theme for competitive and other funds  (4)：
  • 2006 - 2007 ケミカルジェネティクスによる新規有糸分裂阻害化合物の探索と作用機序の解析
  • キネシン機能阻害による異常な細胞周期進行の分子細胞生物学研究
  • 細胞周期分裂期におけるケミカルバイオロジー
  • カイコフィブロイン遺伝子を用いた転写制御の解析
Papers (44)：
  • Asuka Shibuya, Akira Suzuki, Naohisa Ogo, Jun-Ichi Sawada, Akira Asai, Hideshi Yokoyama. Crystal structure of the motor domain of centromere-associated protein E in complex with a non-hydrolysable ATP analogue. FEBS letters. 2023. 597. 8. 1138-1148
  • Jun-ichi Sawada, Kenji Matsuno, Naohisa Ogo, Akira Asai. Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation. Biochemical Pharmacology. 2021. 193. 114789-114789
  • Ryota Fukai, Naohisa Ogo, Taiki Ichida, Masayoshi Yamane, Jun-ichi Sawada, Nao Miyoshi, Hisashi Murakami, Akira Asai. Design, synthesis, and evaluation of a novel prodrug, a S-trityl-cysteine derivative targeting kinesin spindle protein. European Journal of Medicinal Chemistry. 2021. 215. 113288-113288
  • Asuka Shibuya, Naohisa Ogo, Jun-ichi Sawada, Akira Asai, Hideshi Yokoyama. Structure and comparison of the motor domain of centromere-associated protein E. Acta Crystallographica Section D Structural Biology. 2021. 77. 3. 280-287
  • Masayoshi Yamane, Jun-ichi Sawada, Naohisa Ogo, Mai Ohba, Takayuki Ando, Akira Asai. Identification of benzo[d]pyrrolo[2,1-b]thiazole derivatives as CENP-E inhibitors. Biochemical and Biophysical Research Communications. 2019. 519. 3. 505-511
ｍore...
MISC (27)：
  • Mechanism analysis of small-molecule compounds that inhibit chromosome congression during spindle formation. 2024
  • Comparison of crystal structures of the CENP-E motor domain before and after hydrolysis. 2023
  • 鈴木 翠, 渋谷 明日香, 小郷 尚久, 澤田 潤一, 浅井 章良, 荒川 孝俊, 横山 英志. キネシンCENP-Eモータードメインと阻害剤複合体の調製と結晶化. 令和5年(2023年)度日本結晶学会年会. 2023
  • Clarification of the function and inhibition mechanism of CENP-E motor domain by using X-ray crystallography. 2021
  • Asuka Shibuya, Naohisa Ogo, Jun-ichi Sawada, Akira Asai, Hideshi Yokoyama. Structure determination of the motor domain of centromere associated protein E. 25th General assembly and Congress of the international union of Crystallography, IUCr 2021. 2021
ｍore...
Patents (12)：
  • 新規システイン化合物及びその塩
  • Eg5阻害剤
  • Eg5阻害剤
  • キナゾリン化合物を有効成分とする医薬組成物
  • 新規ビアリール誘導体
ｍore...
Lectures and oral presentations  (44)：
  • Mechanism analysis of small-molecule compounds that inhibit chromosome congression during spindle formation
    (2024)
  • Analysis of small-molecule mitotic inhibitors that regulate chromosome congression
    (2024)
  • Functional characterization of small-molecule compounds that inhibit chromosome alignment during spindle formation
    (2024)
  • Functional characterization of small-molecule compounds that inhibit chromosome alignment during spindle formation
    (2023)
  • Characterization of small-molecule compounds that inhibit chromosome alignment during spindle formation
    (2023)
ｍore...
Education (2)：
  • 1992 - 1997 東京工業大学大学院 生命理工学研究科 バイオテクノロジー専攻
  • 1988 - 1992 Tokyo Institute of Technology
Professional career (1)：
  • 博士(工学) (東京工業大学)
Work history (6)：
  • 2004/06 - 現在 University of Shizuoka
  • 2000/01 - 2004/05 Dana-Farber Cancer Institute Posdoc
  • 1998/04 - 1999/12 Tokyo Institute of Technology School of Bioscience and Biotechnology
  • 1997/10 - 1998/03 Tokyo Institute of Technology
  • 1997/04 - 1997/09 岡崎国立共同研究機構基礎生物学研究所 特別研究員
Show all
Committee career (2)：
  • 2022/05 - 2022/11 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2022実行委員会 実行委員
  • 2018/07 - 2018/11 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2018実行委員会 実行委員
Awards (1)：
  • 2023/12 - International Journal of Molecular Sciences, MDPI Trusted Reviewer
Association Membership(s) (4)：
THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE JAPANESE CANCER ASSOCIATION ,  JAPANESE SOCIETY FOR CHEMICAL BIOLOGY ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page

TOP

BOTTOM