Research field (3):
Pharmacology
, Pharmaceuticals - health and biochemistry
, Neuroscience - general
Research theme for competitive and other funds (18):
2019 - 2022 A study on apelin receptor agonists as a new medicine for the treatment of glaucoma
2015 - 2018 A study on apelin as a new therapeutic target for glaucoma using apelin deficiency mouse
2013 - 2016 The utility of adrenaline beta3 receptor agonist as a new drug for Parkinson's disease
2012 - 2015 Research on the apelin as a therapeutic target molecule in ischemic retinopathy using genetically modified animals
2012 - 2013 新規パーキンソン病治療薬としてのβ3受容体アゴニストの開発
2009 - 2011 Research on the onset and progression of amyotrophic lateral sclerosis using genetically modified animals
2007 - グリア細胞を介した神経細胞保護作用に関する研究
2003 - 2004 Modulation of apoptosis by activation of protein kinasse G
2001 - 2002 Dual effect of nitric oxide on cell death : Induction and protection of apoptosis
1999 - 2000 Effects of nitric oxide on pain perception by primary afferent neurons in inflammation
Mechanisms of cytoprotection by nitric oxide
Mechanisms of cell injury by nitric oxide.
Correlation of tyrosine phosphorylation and cell death.
一酸化窒素による細胞保護機構
一酸化窒素による細胞障害機構
抗酸化酵素の活性測定
細胞内抗酸化系を活性化させる化合物の探索
酸化的ストレスによるアポトーシスの誘導機構について
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Papers (29):
Akiko Yamamuro-Tanabe, Yasuhiro Kosuge, Yuki Ishimaru, Yasuhiro Yoshioka. Schwann cell derived-peroxiredoxin protects motor neurons against hydrogen peroxide-induced cell death in mouse motor neuron cell line NSC-34. Journal of Pharmacological Sciences. 2023. 153. 2. 73-83
Akiko Yamamuro-Tanabe, Yurika Mukai, Wataru Kojima, Siyuan Zheng, Naoko Matsumoto, Shoho Takada, Mao Mizuhara, Yasuhiro Kosuge, Yuki Ishimaru, Yasuhiro Yoshioka. An Increase in Peroxiredoxin 6 Expression Induces Neurotoxic A1 Astrocytes in the Lumbar Spinal Cord of Amyotrophic Lateral Sclerosis Mice Model. Neurochemical Research. 2023
Yasuhiro Yoshioka, Yuta Sugino, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda. Dopamine inhibits the expression of proinflammatory cytokines of microglial cells through the formation of dopamine quinone in the mouse striatum. Journal of Pharmacological Sciences. 2022. 148. 1. 41-50
Yuta Sugino, Yasuhiro Yoshioka, Takuma Nishizawa, Yoshiko Wada, Shougo Kotera, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda. Dopamine attenuates LPS-induced expression of cytokines through the inhibition of microtubule-dependent nuclear transport of NF-kappa B p65 in microglial cells. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 178P-178P