Research field (2)：
Bacteriology
, Molecular biology
Research keywords (4)：
Genomics on drug development
, 病原真菌 Pathogenic fungi 酵母 Yeast ゲノム構造 Genome structure ゲノム機能 Genome function ゲノム創薬 Drug development
, Genomics on drug development
, Pathogenic fungi Yeast Genome structure Genome function Drug development
Research theme for competitive and other funds (27)：
2024 - 2027 Development of antifungal drugs that eliminate damage to infected hosts due to fungal cell death
2023 - 2026 抗真菌分子標的薬バンク設立に向けた生命維持遺伝子コード蛋白質阻害剤の探索
2020 - 2022 ERG25機能阻害による抗真菌薬の探索
2018 - 2021 Elucidation of pathogenicity in Candida glabrata by PATHOME analysis
2016 - 2019 Synthetic regulatory mechanism and physiological function of nitric oxidce in yeasts and fungi in
2018 - 2019 シーズA121.迅速標的同定法を用いた抗真菌薬の開発
2017 - 2019 新規抗真菌剤の探索
2015 - 2018 Analysis of the mannnoprotein that is involved in the host intestinal attachment in Candida glabrata
2014 - 2017 Elucidation of the invasive infection mechanism of the opportunistic infectious fungus Candida globrata
2013 - 2016 Synthetic mechanism and physiological role of nitric oxidce in yeasts
2012 - 2015 Elucidation of serum-induced sterol uptake in Pathogenic fungi
2011 - 2013 Epidemiological studies on zoonotic dermatophyte endemic in subtropical area originated from chikens
2011 - 2013 Functional gene analysis for the influence of the indwelling catheter in the Candida ifection
2004 - 2005 Molecular epidemiology of Candida albicans
2004 - 2005 in vivo searching for essential genes in Candida glabata
2004 - 2004 病原性カンジダ酵母における人体内生存戦略遺伝子ネットワークの研究
2003 - 2004 DYNAMIC EXPRESSION OF MORPHOGENESIS RELATED GENES FROM CANDIDA ALBICANS AND TIE ESTIMATION OF PATHOGENICITY USING GENETIC RECOMBINANTS
2003 - 2003 酵母カンジダ・アルビカンスにおける人体内内生存戦略分子機構の解明
2003 - 2003 誘導型アンチセンスRNAによるカンジダ酵母のフェノムプロジェクト
2002 - 2002 誘導型アンチセンスRNAによるカンジダ酵母のフェノムプロジェクト
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Papers (124)：
Michiyo Okamoto, Kaname Sasamoto, Azusa Takahashi-Nakaguchi, Zhao Fujiang, Masashi, Yamaguchi, Hiroji Chibana. CRISPR-Cas9 RNP-mediated deletion of ERG25 in non-albicans Candida species, including Candida auris,. Medical Mycology Journal. 2024
Tadashi Maruyama, Masashi Yamaguchi, Hiroji Chibana. Transverse flagellum contraction synchronized with longitudinal flagellum retraction in Akashiwo sanguinea, a dinokont dinoflagellate. 2024
Masashi Yamaguchi, Mayuko Sato, Azusa Takahashi-Nakaguchi, Michiyo Okamoto, Kiminori Toyooka, Hiroji Chibana. Sandwich freezing and freeze-substitution of Arabidopsis plant tissues for electron microscopy. Microscopy (Oxford, England). 2024
Lin M, Huang Y, Orihara K, Chibana H, Kajiwara S, Chen X. A Putative NADPH Oxidase Gene in Unicellular Pathogenic Candida glabrata Is Required for Fungal ROS Production and Oxidative Stress Response. Journal of fungi (Basel, Switzerland). 2023
Keiko Nakano, Michiyo Okamoto, Azusa Takahashi-Nakaguchi, Kaname Sasamoto, Masashi Yamaguchi, Hiroji Chibana. Evaluation of antifungal selective toxicity using Candida glabrata ERG25 and human SC4MOL knock-in strains. Journal of fungi (Basel, Switzerland). 2023. 9. 10
岩月正人, 渡邊善洋, 大村智, 知花博治, 高橋梓. Search for anti-fungal seeds using genetically engineered Candida glabrata library. 千葉大学真菌医学研究センター報告. 2023. 26
渡邊善洋, 渡邊善洋, 高橋周平, 吉田百合香, 常盤俊之, 稲橋佑起, 稲橋佑起, 穗苅玲, 穗苅玲, 石山亜紀, et al. Search for antifungal compounds produced by mycoparasitic fungi. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
知花博治, 笹本要, 中野恵子, 佐藤美智代, 高橋梓. Screening of in vivo essential genes for the development of antifungal drugs in Candida glabrata. 日本細菌学雑誌(Web). 2022. 77. 1
