Rchr
J-GLOBAL ID：200901052501079764
Update date: Feb. 01, 2024
Nakayama Masamichi
ナカヤマ マサミチ | Nakayama Masamichi
Affiliation and department：
Job title：
Lecturer
Research field (5)：
Polymer chemistry
, Nanobioscience
, Nanomaterials
, Biomaterials
, Biomedical engineering
Research keywords (6)：
温度応答性システム
, ドラッグデリバリーシステム
, 高分子ミセル
, thermoresponsive system
, polymeric micelle
, drug delivery system
Research theme for competitive and other funds (17)：
- 2019 - 2023 Development of innovative human tumor models using cell patch method for high-speed three-dimensional organization
- 2018 - 2022 Induction of vasculogenesis and angiogenesis in three-dimensional tissues by using protein expressions with mRNA delivery
- 2015 - 2017 Photo-controlled surface water repellency for smart cell separation system
- 2013 - 2016 Cancer cell sheet tissue engineering for development of innovative three-dimensional cancer tissue models
- 2013 - 2016 Nrf2 activation inhibits steatohepatitis and liver cancer in overeating-induced obese mice.
- 2012 - 2016 Cell-based Therapies Toward Hemophilia Using Autologous Cells from Hemophilic Individuals
- 2011 - 2016 Fabrication of structually comlicated soft tissue such as liver-tissues and understanding its biological function of teh fabricated liver-tissue
- 2012 - 2015 Development of glycoprotein-biomrkers for biliary tract cancers and establishment of novel diagnostic system using the combination of these biomarkers
- 2011 - 2014 Development of novel bio-therapy using hybrid peptide against intrahepatic cholangiocarcinoma
- 2010 - 2012 Exploration of carbohydrate molecules that regulate malignant behaviors of intrahepatic cholangiocarcinoma, and application for the development of novel molecular-targeting therapy
- 2009 - 2011 Development of liver-target therapy based on cellular modification technology
- 2009 - 2010 Creation of thermoresponsive nano-phase separated surfaces for cell adhesion and detachment
- 2007 - 2008 Newly molecular design of outermost surface functionalized thermoresponsive nano-micelles for drug carrier systems
- 2004 - 2006 Development of novel intelligent tissue culture surfaces to accelerate cell proliferation and recover cell sheet under serum free conditions, using physiologically active peptides
- 2004 - 2005 ガン局所加温により抗腫瘍効果を発現する高分子ミセル型薬物キャリアの分子設計
- 2002 - 2003 温度刺激で高速に薬物を放出する高分子ミセルの分子設計
- Multi targeting drug delivery system using thermo-responsive polymeric micelles
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Papers (50)：
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Masamichi Nakayama, Tomonori Kanno, Hironobu Takahashi, Akihiko Kikuchi, Masayuki Yamato, Teruo Okano. Terminal cationization of poly(N-isopropylacrylamide) brush surfaces facilitates efficient thermoresponsive control of cell adhesion and detachment. SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS. 2021. 22. 1. 481-493
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Masamichi Nakayama, Yuki Toyoshima, Akihiko Kikuchi, Teruo Okano. Micropatterned Smart Culture Surfaces via Multi-Step Physical Coating of Functional Block Copolymers for Harvesting Cell Sheets with Controlled Sizes and Shapes. MACROMOLECULAR BIOSCIENCE. 2021. 21. 3
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Masamichi Nakayama, Yuki Toyoshima, Hiroshi Chinen, Akihiko Kikuchi, Masayuki Yamato, Teruo Okano. Water stable nanocoatings of poly(N-isopropylacrylamide)-based block copolymers on culture insert membranes for temperature-controlled cell adhesion. JOURNAL OF MATERIALS CHEMISTRY B. 2020. 8. 34. 7812-7821
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Jun Akimoto, Masamichi Nakayama, Soichi Takagi, Teruo Okano. Efficient intrahepatic tumor generation by cell sheet transplantation to fabricate orthotopic hepatocarcinoma-bearing model mice for drug testing. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 2019. 107. 5. 1071-1079
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Jun Akimoto, Yoshihiro Ito, Teruo Okano, Masamichi Nakayama. Controlled aggregation behavior of thermoresponsive polymeric micelles by introducing hydrophilic segments as corona components. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY. 2018. 56. 15. 1695-1704
ｍore...
MISC (25)：
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A. Villasante, K. Sakaguchi, J. Kim, N. V. Cheung, M. Nakayama, H. Parsa, T. Okano, T. Shimizu, G. Vunjak-Novakovic. Perfusable Tissue-Engineered Model of Neuroblastoma for Studying Drug Resistance. TISSUE ENGINEERING PART A. 2017. 23. S22-S22
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H. Takahashi, M. Nakayama, T. Shimizu, M. Yamato, T. Okano. Anisotropic cell sheet for three-dimensional design of cell orientation. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 2012. 6. 387-387
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NAKAYAMA Masamichi, OKANO Teruo. Thermoresponsive Polymeric Micelles for Intelligent DDS. 2012. 61. 8. 541-542
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Temperature-responsive Polymeric Materials for Next-generation Biomaterials. 2012. 63. 7. 565-571
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NAKAYAMA Masamichi. Thermoresponsive polymeric materials for drug delivery systems. Drug delivery system. 2008. 23. 6. 627-636
ｍore...
Education (3)：
- - 2001 Kyushu University
- - 1998 九州大学大学院 工学研究科 分子システム工学専攻 修士課程 修了
- - 1996 Kyushu University School of Engineering
Professional career (1)：
- (BLANK) (Kyushu University)
Association Membership(s) (3)：
日本高分子学会
, 日本DDS学会
, 日本バイオマテリアル学会
