Sasaki Sei

ササキセイ | Sasaki Sei

Affiliation and department：

Research field (2)： Cell biology , Nephrology

Research keywords (3)：水輸送 Water Transport , membrane transport , 腎臓内科学 Nephrology

Research theme for competitive and other funds (29)：

2022 - 2025 Discovery of direct water channel inhibitors using aquaporin nanodisc technology
2015 - 2019 Mechanism and physiological role of urinary excretion of aquaporin-2
2013 - 2018 Salt stress-induced responses in health and disease: the role of WNK kinases and new therapeutic strategies
2012 - 2014 Role of aquaporins in endoplasmic reticulum
2010 - 2014 Novel strategy to regulate renal channels and transporters

2005 - 2009 Identification of renal transportsomes by analyzing disease-causing mutants of transporters and their regulators.

2005 - 2009 Function and regulatory system of water transporting aquaporin channels

2002 - 2004 腎糸球体および尿細管細胞の再生医学の腎疾患治療への検討への応用

2001 - 2004 アクアポリンの細胞内輸送・局在・機能分子メカニズムの研究

2001 - 2004 Studies on therapuetic strategy of renal channel diseases.

2000 - 2004 Intracellular trafficking mechanisms of renal C1C and AQP channels

2000 - 2001 Intracellura traffic king of channel proteins and its regulation

1997 - 2000 Molecular Cell Biological Studies of Kidney Membrane Transporter Diseases.

1998 - 1999 Functional expression, intracellular translocation, structure-function relationship of water channels in the collecting duct.

1997 - 1998 STRUCTURE AND FUNCTION OF PEPTIDE SIGNALS FOR INTRACELLULAR LOGALIZATION OF AQP2 VASOPRESSIN WATER CHANNEL

1996 - 1998 Transcriptional regulation of kidney-specific genes

1996 - 1997 Cloning and functional analysis of kidney-specifice gene

1995 - 1997 チャネルとトランスポータの構造・機能相関

1995 - 1997 DEVELOPMENT OF WATER DIURETICS THAT INHIBIT WATER CHANNEL

1995 - 1996 Structural analysis and functional expression of vasopressin water channel

1994 - 1996 Urine concentrating mechanisms examined by molecular biology based techniques

1994 - 1995 Functional expression, intracellular translocation, structure-function relationship of water channels in the collecting duct.

1993 - 1995 Cloning of kidney membrane transport proteins and characterization of its function

1993 - 1995 Development of the drug which prevents the induction of acute renal failure and its clinical application

1991 - 1992 Roles of new bioactine substances on renal disease. Basic and clinical studies.

1989 - 1990 Water and Electrolytes Transport in Reval Nephron Segments

1987 - 1988 Clarification of factors involved in progression of chronic renal failure

腎臓の膜輸送体の構造と機能

Structure and function of Kidney membrane transport protein

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Papers (267)：

Yu Hara, Fumiaki Ando, Daisuke Oikawa, Koichiro Ichimura, Hideki Yanagawa, Yuriko Sakamaki, Azuma Nanamatsu, Tamami Fujiki, Shuichi Mori, Soichiro Suzuki, et al. LRBA is essential for urinary concentration and body water homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 30. e2202125119
Katsuhito Ihara, Tatemitsu Rai, Hidenori Nishida, Sei Sasaki, Shinichi Uchida. Minimal change disease concurrent with acute interstitial nephritis after long-term use of sorafenib in a patient with renal cell carcinoma. CEN case reports. 2021. 10. 2. 287-293
Masaki Sakai, Keiko Yamamoto, Hiroaki Mizumura, Tomoki Matsumoto, Yasuko Tanaka, Yumi Noda, Kenichi Ishibashi, Tadashi Yamamoto, Sei Sasaki. Phosphorylation profile of human AQP2 in urinary exosomes by LC-MS/MS phosphoproteomic analysis. Clinical and Experimental Nephrology. 2020. 24. 9. 762-769
Yuko Miyazawa, Saki Mikami, Keiko Yamamoto, Masaki Sakai, Tatsuya Saito, Tadashi Yamamoto, Kenichi Ishibashi, Sei Sasaki. AQP2 in human urine is predominantly localized to exosomes with preserved water channel activities. Clinical and experimental nephrology. 2018. 22. 4. 782-788
Fumiaki Ando, Shuichi Mori, Naofumi Yui, Tetsuji Morimoto, Naohiro Nomura, Eisei Sohara, Tatemitsu Rai, Sei Sasaki, Yoshiaki Kondo, Hiroyuki Kagechika, et al. AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Nature communications. 2018. 9. 1. 1411-1411

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MISC (451)：

安藤史顕, 油井直史, 森本哲司, 野村尚弘, 蘇原映誠, 頼建光, 佐々木成, 根東義明, 内田信一. FMP-API-1はバゾプレシンに匹敵するAQP2水チャネル活性化作用を持つ新規腎性尿崩症治療薬の開発. 日本腎臓学会誌. 2018. 60. 3. 335-335
Yohei Arai, Eiichiro Kanda, Soichiro Iimori, Shotaro Naito, Yumi Noda, Sei Sasaki, Eisei Sohara, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida. Low white blood cell count is independently associated with chronic kidney disease progression in the elderly: the CKD-ROUTE study. Clinical and experimental nephrology. 2018. 22. 2. 291-298
Soichiro Iimori, Shotaro Naito, Yumi Noda, Hidehiko Sato, Naohiro Nomura, Eisei Sohara, Tomokazu Okado, Sei Sasaki, Shinichi Uchida, Tatemitsu Rai. Prognosis of chronic kidney disease with normal-range proteinuria: The CKD-ROUTE study. PLoS ONE. 2018. 13. 1. e0190493
Yohei Arai, Eiichiro Kanda, Soichiro Iimori, Shotaro Naito, Yumi Noda, Tomoki Kawasaki, Hidehiko Sato, Ryoichi Ando, Sei Sasaki, Eisei Sohara, et al. The use of vitamin D analogs is independently associated with the favorable renal prognosis in chronic kidney disease stages 4-5: the CKD-ROUTE study. CLINICAL AND EXPERIMENTAL NEPHROLOGY. 2017. 21. 3. 481-487
Shintaro Mandai, Eiichiro Kanda, Soichiro Iimori, Shotaro Naito, Yumi Noda, Hiroaki Kikuchi, Masanobu Akazawa, Katsuyuki Oi, Takayuki Toda, Eisei Sohara, et al. Association of serum chloride level with mortality and cardiovascular events in chronic kidney disease: the CKD-ROUTE study. CLINICAL AND EXPERIMENTAL NEPHROLOGY. 2017. 21. 1. 104-111

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Professional career (1)：

M.D. and PhD. (Tokyo Medical and Dental University)

Committee career (3)：

2004 - 日本腎臓学会理事
2004 - 日本内科学会評議員
1999 - 国際腎臓学会理事

Awards (2)：

2002 - 日本腎臓財団学術賞
1994 - 財団法人腎研究会大島賞

Association Membership(s) (5)：

日本透析療法学会 , 国際腎臓学会 , アメリカ腎臓学会 , 日本腎臓学会 , 日本内科学会

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