Rchr
J-GLOBAL ID：200901053074395745
Update date: Nov. 16, 2024
FUJIMURA TSUTOMU
フジムラ ツトム | FUJIMURA TSUTOMU
Affiliation and department：
Job title：
教授
Other affiliations (1)：
Homepage URL (1)：
http://www.tohoku-mpu.ac.jp/pharmacy/lab/lp_a04/
Research field (1)：
Medical biochemistry
Research keywords (6)：
Proteome解析
, ペプチド及びプロテインの構造に関する研究
, ペプチド合成
, Proteome Analysis
, Structual Analysis of Peptide and Proteins.
, Peptide Synthesis
Research theme for competitive and other funds (23)：
- 2022 - 2025 Regulatory mechanism of sialylation of N-glycans by focal adhesion kinase (FAK) and its biological significance
- 2022 - 2025 海洋動物レクチンを細胞内に取り込む分子機序とそれを利用した新規がん治療法の開発
- 2022 - 2025 銀触媒による環化反応を基軸とした抗がん活性マクロライド類の合成と応用研究
- 2020 - 2024 セサモールによるアポトーシス誘導(抗がん作用)における構造活性相関の機能解明
- 2019 - 2022 質量分析法を用いた肥満による喘息の重症・難治化因子の同定と治療法の開発
- 2017 - 2020 ゴマリグナン類の抗がん作用の機能解明
- 2015 - 2019 Development of the multiplex diagnostic method able to make a definitive diagnosis of prostate cancer
- 2014 - 2017 Development of prostate cancer diagnostic marker targeting glycosylation
- 2013 - 2017 Proteomic analyses of mitochondrial respiratory chains from parasitic helminths inhabiting various tissue environments
- 2013 - 2016 Search for new urothelial cancer biomarkers
- 2011 - 2013 Early diagnosis of prostate cancer using cancer-specific the glycosylated peptide antibody
- 2010 - 2012 Proteomic analyses of Ascaris mitochondrial respiratory chain
- 2009 - 2011 Analysis of the mechanism of L-asparaginase to suppress the highly expressed eIF4E in NK-cell lymphoma
- 2008 - 2010 The search of the prostate cancer marker based on blood carbohydrate chain structure and the establishment of the diagnostic method
- 2000 - 2001 Sequential analysis of expressed proteins in organelles from rat liver using 1D/2D SDS-PAGE as a clinical molecullar scanner
- 1999 - オルガネラ分画-プロテオーム解析による発現タンパク質の同定及び機能解析
- 1999 - Identification and function analysis for proteins expressed by genome using subcellular fractionation-proteome analysis
- 1995 - プロテオーム解析
- 1995 - Proteome Research
- 1992 - オピオイドペプチドの合成及びreceptorとの結合様式
- 1992 - Synthesis of Opioid peptides and receptor mechanism
- オルガネラ分画及び同定に関するロボットの開発
- Development of robotics for fractionation and identification of organelles
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Papers (128)：
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Xiao Xu, Noriyoshi Manabe, Shiho Ohno, Sachiko Komatsu, Tsutomu Fujimura, Yoshiki Yamaguchi. 3D structural insights into the effect of N-glycosylation in human chitotriosidase variant G102S. Biochimica et Biophysica Acta (BBA) - General Subjects. 2025. 1869. 1. 130730-130730
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Kyoko Sugiyama, Rin Sakurai, Fumiya Sato, Kazuhiro Watanabe, Tsutomu Fujimura, Katsuhiko Sato. Fluorescence Quenching Effect of a Highly Active Nitroxyl Radical on 7-amino-4-methylcoumarin and Glutathione Sensing. Journal of Fluorescence. 2024
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Akihito Nakajima, Tomoyoshi Shibuya, Takako Yao, Tsutomu Fujimura, Kimie Murayama, Ko Okumura, Akihito Nagahara, Yoshinori Seko. Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in Dextran Sulfate Sodium-Induced Murine Model of Ulcerative Colitis. Medicina (Kaunas, Lithuania). 2024. 60. 4
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Masaki Toda, Kyoko Sugiyama, Fumiya Sato, Yusuke Sasano, Tsutomu Fujimura, Yoshiharu Iwabuchi, Katsuhiko Sato. Electrochemical Characterization of a Novel Organoelectrocatalyst, 7-Azabicyclo[2.2.1]heptan-7-ol (ABHOL), and Its Application to Electrochemical Sensors. Chemical and Pharmaceutical Bulletin. 2024. 72. 3. 249-252
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Shunli Pan, Noriyoshi Manabe, Shiho Ohno, Sachiko Komatsu, Tsutomu Fujimura, Yoshiki Yamaguchi. Each N-glycan on human IgA and J-chain uniquely affects oligomericity and stability. Biochimica et Biophysica Acta (BBA) - General Subjects. 2024. 1868. 2. 130536-130536
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MISC (179)：
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佐藤史也, 中野遥香, 渡邉一弘, 藤村務, 佐藤勝彦. Vancomycin detection based on nanopore measurements. 日本薬学会年会要旨集(Web). 2023. 143rd
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蓬田伸, 渡邉一弘, 染谷明正, 數野彩子, 上野隆, 三浦芳樹, 菅野秀一, 大河原雄一, 藤村務. Doxorubicin耐性細胞に対するセサミン代謝物(7α,7α,8α,8α)-3,4-methylenedioxy-7,9:7,9-diepoxylignane-3,4-diol(SC1)の効果. 日本生化学会大会(Web). 2023. 96th
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大野 賢一, 熊野 征行, 佐藤 勝彦, 藤村 務. 電気化学測定によるセサモールの簡易分析法の開発. 日本薬学会年会要旨集. 2020. 140年会. 27P-am130
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中北 敏賀, 小松 祥子, 丹野 あやか, 服部 友亮, 田口 祥子, 東川 理実, 大野 賢一, 藤村 務, 山下 幸和. LC-ESI-MS/MSによるC21-ステロイド分析におけるプロトン親和性誘導体の評価と定量分析への応用. 日本薬学会年会要旨集. 2020. 140年会. 28P-am190
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小松 祥子, 大野 賢一, 柴田 憲太朗, 細谷 和也, 藤村 務, 本間 勇大, 西村 朝子, 中北 敏賀, 山下 幸和. キノリンカルボン酸試薬を用いたプロトン親和型誘導体化の開発とLC-ESI-MS/MSによるステロイドの定量. 日本薬学会年会要旨集. 2020. 140年会. 28P-am191
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Books (3)：
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分子腎臓病学実験操作法
文光堂 2003
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Ion-pair chromatography for identification of picomolar-order protein on a PVDF membrane
Methods in Molecular Biology, Amino Acid Analysis Protocols 2000
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CHARACTERIZATION OF A SYNTHETIC PEPTIDE AND BY-PRODUCTS USING A PEPTIDE SEQUENCER, A MASS SPECTROMETER, AND CAPILLARY ELECTROPHORESIS
Spectrometry San-ei Publishing Co, 1992
Works (2)：
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オピオイドペプチド合成
1992 -
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Synthesis of opioid peptides
1992 -
Professional career (2)：
- Master(Pharmacology) (Tohoku Pharmaceutical University)
- Doctor(Pharmacology) (Tohoku Pharmaceutical University)
Association Membership(s) (3)：
The Japan Society for Analytical Chemistry
, The Pharmaceutical Society of Japan
, 日本生化学会
