Rchr
J-GLOBAL ID：200901053375954049
Update date: Mar. 26, 2024
KEIKO MUGURUMA
ムグルマ ケイコ | KEIKO MUGURUMA
Affiliation and department：
Job title：
Professor
Research field (3)：
Nervous system function
, Developmental biology
, Neuroscience - general
Research keywords (9)：
神経疾患
, organoid
, neuroscience
, cerebellar development
, ES cells
, iPS cells
, histogenesis
, neural development
, stem cell
Papers (44)：
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Atsushi Tamada, Keiko Muguruma. Recapitulation and investigation of human brain development with neural organoids. IBRO Neuroscience Reports. 2024. 16. 106-117
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Maneesha Shaji, Atsushi Tamada, Kazuya Fujimoto, Keiko Muguruma, Stanislav L Karsten, Ryuji Yokokawa. Deciphering potential vascularization factors of on-chip co-cultured hiPSC-derived cerebral organoids. Lab on a chip. 2024
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Takamasa Kamei, Atsushi Tamada, Toshiya Kimura, Akira Kakizuka, Akio Asai, Keiko Muguruma. Survival and process outgrowth of human iPSC-derived cells expressing Purkinje cell markers in a mouse model for spinocerebellar degenerative disease. Experimental Neurology. 2023
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Kodai Kume, Takashi Kurashige, Keiko Muguruma, Hiroyuki Morino, Yui Tada, Mai Kikumoto, Tatsuo Miyamoto, Silvia Natsuko Akutsu, Yukiko Matsuda, Shinya Matsuura, et al. CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis. American journal of human genetics. 2023. 110. 7. 1086-1097
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Hajime Ozaki, Hidetaka Suga, Mayu Sakakibara, Mika Soen, Natsuki Miyake, Tsutomu Miwata, Shiori Taga, Takashi Nagai, Mayuko Kano, Kazuki Mitsumoto, et al. Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state. Scientific reports. 2022. 12. 1. 17381-17381
ｍore...
MISC (30)：
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Toshiya Kimura, Keiko Muguruma. iPS cell technologies toward overcoming neurological diseases. Folia Pharmacologica Japonica. 2023. 158. 1. 57-63
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六車恵子. オルガノイドで解き明かすヒト脳の神秘. 週刊医学界新聞. 2022. 3492
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玉田篤史, 木村俊哉, 次山ルシラ絵美子, 六車恵子. 脳オルガノイドを用いたヒト脳の発生・疾患の理解. 生体の科学. 2022. 73. 4. 343-347
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MUGURUMA KEIKO. iPS細胞を用いた小脳の発生と病態の解明. Clinical Neuroscience. 2019. 37. 8. 1011-1014
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蟹江 慶太郎, 井口 元三, 坂東 弘教, 松本 隆作, 六車 恵子, 志智 大城, 藤田 泰功, 隅田 健太郎, 福岡 秀規, 小川 渉, et al. 疾患iPS細胞を用いた抗PIT-1抗体症候群疾患モデルの樹立. 日本内分泌学会雑誌. 2019. 95. 1. 390-390
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Books (4)：
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Cerebellum as a CNS Hub
Springer 2021 ISBN:9783030758165
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運動失調のみかた、考え方 小脳と脊髄小脳変性症
中外医学社 2017
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Organ Regeneration based on developmental biology
Springer Nature 2017
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iPS細胞の安全・高品質な作成技術
技術情報協会 2016
Lectures and oral presentations (46)：
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神経オルガノイドによるヒト脳発生と疾患研究
(第 9 回細胞凝集研究会 2023)
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Construction of brain tissues from human iPS cells for investigation of neurological disease
(2023)
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Modeling of human development and disease with pluripotent stem cell-derived neural organoids
(16thInternational Symposium on Nanomedicine (ISNM2023) 2023)
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中枢神経系のオルガノイドの作製とその応用
(第65回歯科基礎医学会学術大会 日本学術会議シンポジウム(市民公開講座) 2023)
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ヒト iPS細胞由来小脳前駆細胞の小脳変性疾患モデルマウスへの 移植
(第46回日本神経科学大会 2023)
ｍore...
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