Tsubouchi Taishi

ツボウチタイシ | Tsubouchi Taishi

Affiliation and department：
Job title： Associate professor
Homepage URL (1)： http://www.med.osaka-cu.ac.jp/bacteriology/

Research field (3)： Pharmaceuticals - chemistry and drug development , Applied microbiology , Bacteriology

Research keywords (5)： Drug discovery , Applied microbiology , Marine Actinomyces , 転写制御機構 , Antimicrobial resistance

Research theme for competitive and other funds (19)：

2024 - 2025 深海性放線菌が生産する天然物に着目したスキルス胃癌を特異的に排除する抗癌剤の開発
2021 - 2025 Development of anti-scirrhous stomach cancer produced by the deep-sea actinomyces
2022 - 2025 Creation of Active Substances from Deep-sea Actinomycetes to Disrupt Drug-Resistant Acinetobacter spp.
2022 - 2025 深海放線菌が産生する新規の胃癌抑制物質の同定
2021 - 2024 Characteristic analysis of a novel anti-Candida auris substance derived from deep-sea actinomycetes

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Papers (28)：

東田充功, 老沼研一, 並川浩己, 榮山新, 坪内泰志, 山田康一, 仁木満美子, 渡辺徹也, 浅井一久, 掛屋弘, et al. リファンピシンの高病原性肺炎桿菌に対する粘性抑制作用機序の解明. 日本化学療法学会雑誌. 2023. 71. 2. 232-233
Taishi Tsubouchi. Haneummycin, a new 22-membered macrolide lactam antibiotic, produced by marine-derived Streptomyces sp. KM77-8. The Journal of Antibiotics. 2023. 76. 11
Kenshi Yamane, Mamiko Niki, Taishi Tsubouchi, Tetsuya Watanabe, Kazuhisa Asai, Ken-Ichi Oinuma, Arata Sakiyama, Chaogetu Saren, Yuki Matsumoto, Koichi Makimura, et al. A Culture Supernatant from an Actinomycete sp. Affects Biofilm Formation and Virulence Expression of Candida auris. Medical mycology journal. 2023. 64. 1. 7-17
Mitsunori Tohda, Ken-Ichi Oinuma, Arata Sakiyama, Taishi Tsubouchi, Mamiko Niki, Hiroki Namikawa, Kenshi Yamane, Koichi Yamada, Tetsuya Watanabe, Kazuhisa Asai, et al. Rifampicin exerts anti-mucoviscous activity against hypervirulent Klebsiella pneumoniae via binding to the RNA polymerase β subunit. Journal of global antimicrobial resistance. 2022. 32. 21-28
Ken-Ichi Oinuma, Masato Suzuki, Arata Sakiyama, Taishi Tsubouchi, Kozo Saeki, Kanako Sato, Mamiko Niki, Koichi Yamada, Keigo Shibayama, Hiroshi Kakeya, et al. Genomic characterization of triple-carbapenemase-producing Acinetobacter baumannii. JAC-antimicrobial resistance. 2021. 3. 4. dlab191

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MISC (37)：

榮山新, 老沼研一, 鈴木仁人, 佐伯康匠, 坪内泰志, 仁木満美子, 山田康一, 柴山恵吾, 掛屋弘, 金子幸弘. Acinetobacter baumannii OCU_Ac16aが保持するblaTMB-1とblaOXA-58の機能性の検討. 緑膿菌感染症研究会講演記録. 2021. 55回. 18-19
藤本凜太郎, 坪内泰志, 鈴木仁人, 仁木誠, 仁木満美子, 老沼研一, 山田康一, 掛屋弘, 金子幸弘. 当院で分離された多剤耐性Acinetobacter baumannii株の完全長ゲノム解析から見出した知見. 緑膿菌感染症研究会講演記録. 2021. 55回. 21-23
並川浩己, 仁木誠, 仁木満美子, 山田康一, 中家清隆, 榮山新, 老沼研一, 坪内泰志, 金子幸弘, 首藤太一, et al. Klebsiella pneumoniae菌血症の30日後死亡予測因子の解析遺伝子学的特徴も含めて. 感染症学雑誌. 2020. 94. 3. 426-427
仁木満美子, 山入和志, 老沼研一, 坪内泰志, 掛屋弘, 金子幸弘. 嫌気性菌研究の最前線真菌のバイオフィルム形成における嫌気性菌の役割. 日本嫌気性菌感染症学会雑誌. 2020. 50. 1. 23-23
老沼研一, 鈴木仁人, 佐伯康匠, 坪内泰志, 仁木満美子, 山田康一, 柴山恵吾, 掛屋弘, 金子幸弘. 当院で分離されたカルバペネム高度耐性Acinetobacter baumannii株のカルバペネマーゼ遺伝子の周辺構造と接合伝達性. 緑膿菌感染症研究会講演記録. 2019. 53回. 45-46

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Patents (2)：

Lectures and oral presentations (4)：

薬剤耐性菌対策に向けた海洋微生物資源ライブラリの構築
(Zoobiquity symposium 2019)
薬剤耐性菌対策に向けた海洋微生物資源ライブラリの構築
(日本防菌防黴学会第46回年次大会 2019)
当院で分離されたカルバペネム高度耐性Acinetobacter baumannii株のカルバペネマーゼ遺伝子の周辺構造と接合伝達性
(緑膿菌感染症研究会講演記録 2019)
hypermucoviscous Klebsiella pneumoniaeによる菌血症の臨床的特徴と予測因子の解析
(感染症学雑誌 2019)

Education (2)：

1999 - 2005 The University of Tokyo Graduate School of Agricultural and Life Sciences Department of Biotechnology
1995 - 1999 日本大学農獣医学部応用生物科学科

Professional career (1)：

(BLANK) (The University of Tokyo)

Work history (6)：

2022/04 - 現在 Osaka Metropolitan University Graduate School of Medicine Basic Medicine Course Associate professor
2020/04 - 2022/03 Osaka City University Graduate School of Medicine Basic Medicine Course Associate professor
2017/07 - 2020/03 Osaka City University Graduate School of Medicine Basic Medicine Course Specially-appointed Lecturer
2013/04 - 2017/06 Japan Agency for Marine-earth Science and Technology Research and Development (R&D) Center for Marine Biosciences Vice Senior Staff Member of Technology
2008/04 - 2013/03 Japan Agency for Marine-earth Science and Technology Scientist

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Committee career (1)：

2014/04 - 現在マリンバイオテクノロジー学会若手の会

Association Membership(s) (4)：

The Japanese Association for Infectious Disease , SOCIETY OF ACTINOMYCETES JAPAN , The Japanese Society for Marine Biotechnology , Japan Society for Bioscience, Biotechnology, and Agrochemistry

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