Takakusagi Yoichi

タカクサギヨウイチ | Takakusagi Yoichi

Affiliation and department：
Job title： Group leader/Team leader
Other affiliations (2)：

National Institutes for Quantum Science and Technology
Graduate School of Science and Engineering, Chiba University Department of Quantum Life Science Visiting Professor

Homepage URL (1)： https://www.jove.com/author/Yoichi_Takakusagi

Research field (6)： Radiology , Biomedical engineering , Pharmaceuticals - chemistry and drug development , Biochemistry , Biomaterials , Molecular biology

Research keywords (19)： Hyperpolarization , Dynamic Nuclear Polarization , Imaging , 代謝診断治療 , Theranostics , 未病 , Radiosensitizer , Hypoxia-activated Prodrug , Biosensor , Angiogenesis , Tumor , Cancer , EPR , CEST , MRI , Bioinformatics , Peptides , Small Molecule , Phage Display

Research theme for competitive and other funds (12)：

2023 - 2033 分子・生命・生理科学が融合した次世代新分野創成のためのスピン生命フロンティアハブの創設 (スピン生命フロンティア; Spin-L) ( (代表: 小安重夫)
2020 - 2030 量子生命技術の創製と医学・生命科学の革新 (代表: 馬場嘉信)
2023 - 2028 超偏極利活用プラットフォームの整備とトリプレットDNPによるがん治療効果判定技術の開発 (代表: 根来誠)
2023 - 2027 Establishment of Non-clinical POC using hyperpolarized MRI and 3D cultured cancer tissue for personalized medicine of metabolic inhibitor therapy.
2023 - 2026 超偏極-核磁気共鳴法で創発する未病の科学と代謝診断治療学

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Papers (64)：

Iori Tamura, Daichi M. Sakamoto, Bo Yi, Yutaro Saito, Naoki Yamada, Yoichi Takakusagi, Shinsuke Sando. Pimonidazole-alkyne conjugate for sensitive detection of hypoxia by Cu-catalyzed click reaction. Anal Sci. 2024. in press
Iori Tamura, Daichi M. Sakamoto, Bo Yi, Yutaro Saito, Naoki Yamada, Jumpei Morimoto, Yoichi Takakusagi, Masafumi Kuroda, Shimpei I. Kubota, Hiroshi Harada, et al. Click3D: A whole-organ 3D imaging method utilizing tissue clearing-compatible click reaction. ChemRxiv. 2024
Daichi M. Sakamoto, Iori Tamura, Bo Yi, Sho Hasegawa, Yutaro Saito, Naoki Yamada, Yoichi Takakusagi, Shimpei I. Kubota, Minoru Kobayashi, Hiroshi Harada, et al. Whole-Body and Whole-Organ 3D Imaging of Hypoxia Using an Activatable Covalent Fluorescent Probe Compatible with Tissue Clearing. ACS Nano. 2024. 18. 6. 5167-5179
Tomoto Ura, Nanako Sakakibara, Yu Hirano, Taro Tamada, Yoichi Takakusagi, Kentaro Shiraki, Tsutomu Mikawa. Activation of oxidoreductases by the formation of enzyme assembly. Scientific Reports. 2023. 13. 1
Daichi M. Sakamoto, Iori Tamura, Bo Yi, Sho Hasegawa, Yutaro Saito, Naoki Yamada, Yoichi Takakusagi, Shimpei I. Kubota, Hiroshi Harada, Kenjiro Hanaoka, et al. Whole-body and whole-organ 3D imaging of hypoxia using activatable covalent fluorescent probe compatible with tissue clearing. ChemRxiv. 2023

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MISC (109)：

Akihito Goto, Hiroyuki Yatabe, Norikazu Koyasu, Kazutoshi Yamamoto, Murali C. Krishna, Keita Saito, Yoichi Takakusagi, Yutaro saito, Shinsuke Sando. Development of a DNP-MRI molecular probe for detecting dipeptidyl peptidase-4 activity in vivo based on the substrate recognition mechanism. ISMRM2024. 2024
Hiroyuki Yatabe, Yutaro Saito, Yoichi Takakusagi, Keita Saito, Kazutoshi Yamamoto, Murali C. Krishna, Shinsuke Sando. In vivo detection and imaging of aminopeptidase activities related to renin-angiotensin system using newly designed hyperpolarized MR probes. ISMRM2024. 2024
Maiko Ono, Bolati Wulaer, Tomoteru Yamasaki, Toshihiro Sakamoto, Kosei Hirata, Keita Saito, Yoichi Takakusagi, Ming-Rong Zhang, Jun Nagai, Yuhei Takado. Astrocytes contribute to signals of hyperpolarized 13C pyruvate in the brain. ISMRM2024. 2024
Norikazu Koyasu, Hiroyuki Yatabe, Yoichi Takakusagi, Yutaro Saito, Shinsuke Sando, Murali C. Krishna, Kazutoshi Yamamoto. A newly designed hyperpolarized aminopeptidase N probe sensitively detects early therapeutic responses heterogenously on pancreatic tumors. Experimental Nuclear Magnetic Resonance Conference (ENC 2024). 2024
高草木洋一, 小林竜馬, 齋藤圭太, 根来誠. 量子技術を用いた超高感度 MRI/NMR. 光・量子飛躍フラッグシッププログラム(Q-LEAP)第6回シンポジウム. 2024

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Patents (4)：

伝送装置および伝送方法
タンパク質結晶形成制御剤
炭化水素精製用不純物吸着剤
タンパク質結晶化条件探索剤及びタンパク質結晶化条件探索方法

Books (8)：

超高感度代謝イメージングを実現する動的核偏極法
日本神経回路学会誌 2023
Hyperpolarized-magnetic resonance metabolic imaging and its application for Life Science and Medicine
OPTRONICS 2020
最先端の研究開発量子科学技術研究開発機構第 4 回「量子生命科学」の発進
日本原子力学会誌 ATOMOΣ 2019
放射線増感剤 SQAP について
創薬のひろばライフサイエンス製品ガイドブック (株式会社エー・イー企画) 2016
産学官連携と実用化への挑戦ー層状ケイ酸塩を用いたスクワランの非加熱精製法の確立と新産業創出の可能性ー
理大科学フォーラム東京理科大学出版会 2011

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Lectures and oral presentations (69)：

A Newly Designed Hyperpolarized Aminopeptidase N Probe Sensitively Detects Early Therapeutic Responses Heterogenously on Pancreatic Tumors
(ISMRM2024 2024)
X-nuclei, biomolecules and their application
(ISMRM2024 Educational lecture 2024)
超偏極 MRI/NMR 利活用テストベッドの整備状況と代謝診断治療の創成に向けた取り組み
(第二回 DNP 研究会 2024)
超偏極 MRI による in vivo 酸素濃度測定のための長寿命分子の評価
(日本化学会第 104 春季年会 (2024) 2024)
精密に設計された超偏極分子プローブ群を用いる複数のアミノペプチダーゼ活性の生体内同時検出
(日本化学会第 104 春季年会 (2024) 2024)

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Works (8)：

未病の科学と代謝診断治療学
2023 -
量子技術を用いた超高感度 MRI/NMR
2020 -
DDS 技術を基盤としたがん診断治療法の開発
2017 -
動的核偏極ー磁気共鳴分子プローブの創製、応用計測
2014 -
がんのスピン共鳴画像解析 (EPR酸素イメージング、超偏極-MR代謝イメージング)
2011 -

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Education (3)：

2003 - 2006 Tokyo University of Science
2001 - 2003 Tokyo University of Science
1997 - 2001 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy

Professional career (1)：

Doctor of Pharmacy (Tokyo University of Science)

Work history (17)：

2024/04 - 現在 National Institutes for Quantum Science and Technology Group leader/Team leader
2022/11 - 現在 Graduate School of Science and Engineering, Chiba University Department of Quantum Life Science Visiting Professor
2022/07 - 2024/03 National Institutes for Quantum and Radiological Science and Technology
2021/04 - 2022/06 National Institutes for Quantum and Radiological Science and Technology Institute of Quantum Life Science, Quantum Hyperpolarized MRI Group Semi Leader, Senior Scientist
2020/08 - 2021/03 Quantum Hyperpolarized MRI group, Institute of Quantum Life Science, QST

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Committee career (13)：

2023/11 - 現在 Spin-L ハブ会議委員
2023/10 - 現在量子生命科学会第 6 回大会実行委員
2023/10 - 現在日本磁気共鳴医学会第 52 回大会プログラム委員
2023/04 - 現在量子生命科学会総務委員会委員
2023/04 - 現在量子生命科学会評議員

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Awards (9)：

2024/05 - Bruker (ISMRM2024) 3rd place Award
2023 - 量子科学技術研究開発機構部門間交流会ポスター賞
2019 - The 14th Molecular Imaging Conference Poster Award (Collaborator)
2018 - 12th QCM Seminar Excellent Poster Award
2018 - The 115th Scientific Meeting of the JSMP Testimonial

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Association Membership(s) (8)：

量子生命科学先端フォーラム , 日本分子イメージング学会 , 量子生命科学会 , ISMRM , 日本 DDS 学会 , 日本分子生物学会 , 日本薬学会 , 日本磁気共鳴医学会

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