Rchr
J-GLOBAL ID：200901054033089849
Update date: Aug. 28, 2024
Nakahara Tsutomu
ナカハラ ツトム | Nakahara Tsutomu
Affiliation and department：
Job title：
Professor
Research field (2)：
Pharmacology
, Pharmaceuticals - health and biochemistry
Research keywords (2)：
Vascular Biology
, Cardiovascular Pharmacology
Research theme for competitive and other funds (16)：
- 2021 - 2024 Establishment of a novel experimental model of retinal pericyte deletion for accelerating the development of therapeutic agents for diabetic retinopathy
- 2016 - 2019 Mechanisms of neuronal-glial-vascular interactions in the retina and the development of novel strategies for treating retinal diseases
- 2016 - 2019 Regulation of angiogenesis by a novel VEGF receptor binding protein
- 2014 - 2017 Regulatory mechanisms of neurovascular coupling by retinal Muller cells and the application for development of anti-glaucoma drugs
- 2013 - 2015 網膜における血管-神経ワイヤリング破綻機構の解明と予防・回復法の確立
- 2012 - 2015 Elucidation of mechanisms for regulating retinal circulation and identification of target molecule for novel preventive and/or therapeutic drugs for retinopathy
- 2011 - 2013 網膜における血管-神経相互依存性の分子機構と加齢・糖尿病による影響
- 2011 - 2013 Mechanisms of neuronal-glial-vascular interactions in the retina and the application for development of anti-glaucoma drugs
- 2009 - 2011 Elucidation of the molecular basis attributed to onset of abnormal retinal hemodynamics and strategy of novel prevention drugs for retinopathy
- 2008 - 2010 Molecular basis for the homeostatic mechanisms that maintain retinal blood vessels and the application for development of anti-glaucoma drugs
- 2005 - 2006 動的光散乱法を中心とした糖尿病性白内障進展過程の解析と予防薬/治療薬開発への応用
- 2005 - 2006 網膜における血管内皮細胞間ギャップの視覚化と血管透過性に対する薬物評価系への応用
- 2002 - 2003 血管平滑筋のcyclicGMP排出機構とその生理学的・病態生理学的意義
- 2000 - 2001 Development of high-resolution digital fundus camera for small animals and application of it to studies on analysis of responsiveness of retinal blood vessels
- 2000 - 2001 網膜由来弛緩因子の生理的・病態生理的役割の解明
- 1998 - 1999 Studies on responsiveness of rat retial blood vessels with a newly developed digital funduscope system for small animals
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Papers (183)：
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Rina Yagasaki, Akane Morita, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara. The Anti-Diabetic Drug Metformin Suppresses Pathological Retinal Angiogenesis via Blocking the mTORC1 Signaling Pathway in Mice (Metformin Suppresses Pathological Angiogenesis). Current eye research. 2024. 49. 5. 505-512
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Honoka Yamagishi, Nozomu Kirai, Akane Morita, Toshihide Kashihara, Tsutomu Nakahara. Role of monocarboxylate transporters in AMPK-mediated protection against excitotoxic injury in the rat retina. European journal of pharmacology. 2024. 176510-176510
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Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara. Role of mammalian target of rapamycin in the formation and progression of retinopathy of prematurity-like vascular abnormalities in neonatal rats. Microvascular research. 2024. 152. 104626-104626
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Toshihide Kashihara, Yui Morita, Misaki Hatta, Sae Inoue, Yume Suzuki, Akane Morita, Tsutomu Nakahara. YAP activation in Müller cells protects against NMDA-induced retinal ganglion cell injury by regulating Bcl-xL expression. Frontiers in pharmacology. 2024. 15. 1446521-1446521
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Erika Kamiya, Akane Morita, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara. The process of methylglyoxal-induced retinal capillary endothelial cell degeneration in rats. Microvascular research. 2023. 146. 104455-104455
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MISC (162)：
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森田茜, 宮永香純, 浅野大樹, 森麻美, 森麻美, 坂本謙司, 坂本謙司, 中原努. 新生仔マウスにおけるVEGF受容体下流シグナル分子活性の可視化. 日本眼薬理学会プログラム・講演抄録集. 2021. 40th
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森田茜, 宮永香純, 浅野大樹, 有馬志保, 森麻美, 森麻美, 坂本謙司, 坂本謙司, 長光亨, 中原努. The Visualization of ERK Activity at the Vascular Front in the Neonatal Mouse Retina. 眼薬理. 2021. 35. 1
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坂本 謙司, 浅野 大樹, 森田 茜, 森 麻美, 中原 努. 【網膜変性疾患や視覚障害を標的とした新規治療戦略を目指して】網膜変性疾患におけるmicroRNAの発現変動. 日本薬理学雑誌. 2020. 155. 2. 81-86
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浅野大樹, 森田茜, 森麻美, 中原努. The mechanism of activation of matrix metalloproteinase-9 in the neonatal rat model of NMDA-induced retinal neurodegeneration. 日本薬学会年会要旨集(CD-ROM). 2020. 140年会. 26I-pm14
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森麻美, 江沢佑菜, 浅野大樹, 森田茜, 坂本謙司, 坂本謙司, 中原努. Resveratrol dilate retinal arterioles via AMPK activation in rats. 日本薬学会年会要旨集(CD-ROM). 2020. 140年会. 27Q-am048
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Books (3)：
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パートナー薬理学
南江堂 2019 ISBN:9784524403523
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グッドマン・ギルマン 薬理書 薬物治療の基礎と臨床
廣川書店 2013
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最新薬理学
廣川書店 2012 ISBN:9784567490207
Lectures and oral presentations (147)：
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発達初期に生じる血管形成遅延は血管パターン異常を引き起こす:新生仔マウス網膜における検討
(第123回日本解剖学会総会・全国学術集会(東京) 2018)
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マウスNMDA 誘発網膜神経傷害におけるmiR-124の役割
(第138回日本薬理学会関東部会(東京) 2018)
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マウスNMDA 誘発網膜神経傷害に対するsalburinalの影響
(第138回日本薬理学会関東部会(東京) 2018)
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網膜色素変性症モデルマウスにおけるmicroRNAの解析
(第138回日本薬理学会関東部会(東京) 2018)
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新生仔マウス網膜において観察される血管異常と細胞外マトリックスとの関連:新規未熟児網膜症モデルとしての可能性
(第138回日本薬理学会関東部会(東京) 2018)
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Education (2)：
- - 1996 University of Shizuoka Graduate School, Division of Pharmaceutical Sciences 薬理学
- - 1991 University of Shizuoka Faculty of Pharmaceutical Science 製薬学科
Professional career (1)：
Work history (6)：
Association Membership(s) (5)：
日本解剖学会
, 日本眼薬理学会
, 日本薬理学会会員
, 日本薬理学会評議員
, 日本血管生物医学会会員
