Rchr

J-GLOBAL ID：200901054384810803 Update date: Sep. 19, 2024

Kubota Satoshi

クボタサトシ | Kubota Satoshi

Affiliation and department：
Job title： Professor

Research field (3)： Oral medicine , Medical biochemistry , Molecular biology

Research keywords (10)：レトロウイルス , 軟骨 , 遺伝子発現制御 , RNA , CCNファミリー遺伝子 , HIV , cartilage , nulceus , RNA , CCN family

Research theme for competitive and other funds (63)：

2024 - 2027 Investigation on phase separation-mediated regulation of cell differentiation by droplet transpricptomics
2023 - 2027 Development of dropletomics that clarifies transcriptional regulation under liquid-liquid phase separation
2024 - 2027 糖代謝障害が招く軟骨肥大性細胞老化を介したO Aの発症機構の解明とC C N2の役割
2023 - 2026 Intracellular proteostatic function of CCN2 in chondrocytes during endochondral ossification
2022 - 2025 象牙芽細胞の表面に突き出た細胞小器官の機能解析と象牙質再生への応用

2022 - 2025 S-アデノシルメチオニンによる軟骨基質産生の新制御機構の解明-ポリアミンを中心に

2022 - 2025 非コードRNAを介した新たな軟骨ホメオスタシスとその変性メカニズムの解明

2021 - 2025 Regulation of skeletogenesis by long noncoding RNAs through CCN2

2021 - 2024 新規軟骨老化促進因子CCN3の加齢に伴った発現誘導と細胞周期停止機構の解明

2021 - 2024 変形性足関節症におけるCCN3を介した新たな軟骨細胞老化制御機構の解明

2021 - 2024 長鎖非コードRNAによる骨細胞メカニカルストレス応答制御機構の解明

2020 - 2024 Pioneering chondroneutrigenomics research and its development into chondroneutrigenetics

2021 - 2023 Inverse genetics: A new methodology for the identification of key genes of somatic cell differentiation

2020 - 2023 CCN2の転写因子様機能を介した線維症のキープレイヤー筋線維芽細胞分化機構の解明

2019 - 2023 細胞アンテナによる象牙質再生への道を拓く基礎研究

2019 - 2023 CD302の新機能:破骨細胞の分化制御とその機構及び骨・軟骨代謝研究への展開

2019 - 2023 Intracellular function and new extracellular signaling pathways of CCN proteins and their common molecular base

2019 - 2022 Metabolic control of periodontal fibrotic diseases by fluorides: A basic study

2018 - 2022 Analysis of mechanism of regulation of CTGF/CCN2 by RUNX2 in tooth formation

2018 - 2022 The study of the regulatory mechanisms of cancer bone destruction metabolism and immunity in Hedgehog signaling

2019 - 2021 Regulation of CCN2 by an endogenous UTR blocker and its biological significance

2017 - 2020 Neutrigenomics studies on endochondral ossification and articular cartilage mainteinance/regeneration

2017 - 2020 Mechanism of onset of osteoarthritis caused by obesity and regulatory effects of CCN2

2016 - 2020 The investigation of the mechanism of regular arrangement of odontoblasts via extracellular environment sensing sensors

2017 - 2019 Novel regulatory mechanism of endochondral ossification via CCN2-VASH1 axis

2017 - 2019 New potential of CCN2: Functional evaluation as a Warburg effector

2016 - 2019 Roles of CCN2 and Rab14 in the formation of extracellular matrix

2016 - 2019 Role of Sox9 and its ubiquitin ligase on the Circadian growth rhythm in chondrocytes

2015 - 2018 Differential analysis and application at the molecular level of the immunosuppressant action base seen from cartilage tissue

2015 - 2018 Analysis of the CTGF/CCN2 expression promotion system which classified cartilage regenerative therapy into the field

2015 - 2018 Mechanism and expression of CD302 as a new regulator of osteoclast maturation

2015 - 2018 Establishment of molecular basis of CCN family proteins for therapeutic use and its related translational research

2014 - 2017 Effect of CCN2 on the osteocyte function regulating the osteoclast formation, and its possibility as a novel drug of osteoporosis

2014 - 2016 The presence and its significance of non-canonical action of decoy receptors

2014 - 2016 後天的に顔面骨格形態を決定する新たな分子メカニズムの解明

2013 - 2016 Novel function of CCN3: A regulator of endochondral ossification

2013 - 2016 Investigation on the biological diarchy by CCN2 and CCN3 for integrated tissue development

2012 - 2015 Elucidation of molecular basis of CCN family action as masterminds and its medical application

2011 - 2013 軟骨再生を目指したCTGF/CCN2発現促進因子の同定とその応用

2011 - 2013 Analysis of molecular mechanism of muscle heterotopic ossification by forming a network with CCN family proteins

2011 - 2013 Functional analysis of CCN2 as a metabolic supporter and potential clinical applications in chondrocyte regeneration

2011 - 2012 A new protein transport system in cartilage: Multilayered transcytosis

2010 - 2011 The analysis of binding of CTGF/CCN2 to RANK and its effects on RANK/RANKL signaling

2009 - 2011 Development and medical application of peptide and RNA aptamers that bind to CCN2

2009 - 2011 Role of a ubiquitin ligase for Sox9 on endochondral ossification and neurological disorder

2007 - 2011 Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application

2008 - 2010 Clarification of molecular mechanism on the osteoclastogenesis promoted by CCN family 2/connective tissue growth factor

2007 - 2008 Regulation of CCN family gene expression via micro RNA regulatory network and its Biological signficance

2007 - 2008 Analysis of the role of cartilage-specific gene in endochondral bone formation using BAC (bacterial artificial chromosome)-transgenic mice

2007 - 2008 MMPの新機能:マトリクス合成促進因子の転写因子としての役割

2005 - 2006 Role of CCN2 as a trans-modulator in the integrated development of bone, cartilage and hematopoietic systems

2003 - 2006 The role of CTGF as a novel tissue-regenerating factor, regenerin, and its application for medical and dental tissue engineering

2004 - 2005 RNA干渉を用いたCCN遺伝子ファミリーの包括的機能解析とその応用

2002 - 2005 Gene Therapy for Periodontal Diseases -Regulation of host response by local gene delivery-

2003 - 2004 間葉系幹細胞の遺伝子発現プロファイル解析と硬組織再生への応用

2002 - 2003 Functional dissection and medical application of the 4 modules in the chondrocyte-derived growth factor, ecogenin/CTGF.

2001 - 2002 軟骨成長因子エコジェニン/CTGFによる生体デザインを目指す研究

2001 - 2002 Functional analysis of the cartilage-derived multifunctional growth factor ecogenin/CTGF by using mutant animals

2000 - 2001 Investigation of the intracellular function of human ecogenin/CTGF, a chondrocyte-derived growth factor.

2000 - 2001 Development of analytical method for each domain of CTGF/ecogenin and its clinical application.

1999 - 2001 Investigation of the regulatory mechanism of gene expression of human ecogenin/CTGF, a chondrocyte-derived growth factor.

1999 - 2000 軟骨由来成長因子エコジェニン/CTGFを用いた歯周組織再建への試み

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Papers (227)：

H.T. Do, M. Ono, Z. Wang, W. Kitagawa, A.T. Dang, T. Yonezawa, T. Kuboki, T. Oohashi, S. Kubota. Inverse genetics tracing the differentiation pathway of human chondrocytes. Osteoarthritis and Cartilage. 2024
Loc Dinh Hoang, Eriko Aoyama, Miki Hiasa, Hiroshi Omote, Satoshi Kubota, Takuo Kuboki, Masaharu Takigawa. Positive Regulation of S-Adenosylmethionine on Chondrocytic Differentiation via Stimulation of Polyamine Production and the Gene Expression of Chondrogenic Differentiation Factors. International Journal of Molecular Sciences. 2023. 24. 24. 17294-17294
Harumi Kawaki, Satoshi Kubota, Masaharu Takigawa. Cellular Fluorescence Imaging for the Evaluation of Bioactivity of CCN Family Proteins. Methods in molecular biology (Clifton, N.J.). 2023. 2582. 23-29
Satoshi Kubota, Harumi Kawaki, Masaharu Takigawa. Protocols for Screening Peptides Binding to CCN Family Proteins and Their Extended Utility. Methods in molecular biology (Clifton, N.J.). 2023. 2582. 87-101
Seiji Kondo, Satoshi Kubota, Masaharu Takigawa. Analyses of the Posttranscriptional Regulation of CCN Genes: Approach to Multiple Steps of CCN2 Gene Expression. Methods in molecular biology (Clifton, N.J.). 2023. 2582. 127-155

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MISC (310)：

桑原実穂, 廣瀬一樹, 近藤星, 古松毅之, 中田英二, 原哲也, 久保田聡, 服部高子. 軟骨組織におけるCCN3の老化マーカーとしての役割と、CCN3の異所性発現による加齢様退行性変化の促進. 日本結合組織学会学術大会プログラム・抄録集. 2023. 55回. 158-158
桑原実穂, 廣瀬一樹, 廣瀬一樹, 奥田龍一郎, HABUMUGISHA Janvier, 近藤星, FU Shanqi, 大野充昭, 古松毅之, 中田英二, et al. CCN3, a senescence marker of cartilage, correlate with osteoarthritis irrespective of age and weight bearing. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
奥田龍一郎, 廣瀬一樹, 中田英二, 鉄永智紀, 山田和希, 小浦卓, 井上智博, 尾崎敏文, 久保田聡, 服部高子. Correlation between hip osteoarthritis and CCN3. 移植(Web). 2023. 58. 3
LOC Hoangdinh, LOC Hoangdinh, 青山絵理子, 日浅未来, 表弘志, 久保田聡, 窪木拓男, 滝川正春. S-adenosylmethionine promotes chondrocyte differentiation via polyamine synthesis and gene expression of growth factors. 日本軟骨代謝学会プログラム・抄録集. 2023. 35th
東原直裕, 東原直裕, 東原直裕, 青山絵理子, 古松毅之, 久保田聡, 尾崎敏文, 滝川正春. The effects of binding of CCN2 to GDF5 and its receptors on chondrocytes. 日本軟骨代謝学会プログラム・抄録集. 2023. 35th

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Patents (3)：

細胞接着方法
ヒト免疫不全ウイルス感染の予防または治療の方法
Method for Preventing or Treating a Human Immunodeficiency Virus Infection

Books (24)：

Encyclopedia of Signaling Molecules 2nd Edition
2018
Promoter analyses of CCN genes: in Methods in Molecular Biology: CCN Proteins: Methods and Protocols
Springer 2017
Production of recombinant CCN family 2 protein in Escherichia. coli: in Methods in Molecular Biology: CCN Proteins: Methods and Protocols
Springer 2017
In vivo evaluation of cartilage regenerative effects of CCN2 protein: in Methods in Molecular Biology: CCN Proteins: Methods and Protocols
Springer 2017
Cell biological assays for measuring chondrogenic activities of CCN2 protein: in Methods in Molecular Biology: CCN Proteins: Methods and Protocols
Springer 2017

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Lectures and oral presentations (526)：

象牙芽前駆細胞における一次繊毛と古典的WNTシグナルの相互作用
(第43回日本分子生物学会年会 2020)
軟骨組織におけるCCN3の老化促進作用
(第43回日本分子生物学会年会 2020)
non-coding RNAを介したメトホルミンの抗線維化作用の解析
(第43回日本分子生物学会年会 2020)
フッ素イオンによるCCNファミリー遺伝子の制御を介した歯肉線維化抑制効果の検証
(第79回日本矯正歯科学会 2020)
Regulation of CCN3 gene expression by glycolytic activity in chondrocytes
(The 9th International Orthodontic Congress 2020)

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Works (2)：

CTGF, Atlas of Genetics and Cytogenetics in Oncology and Haematology, CTGF ID40192ch6q23
Kubota, S, M. Takigawa 2007 -
CCN2 Molecule Page, UCSD/Nature, The Signaling Gateway, 2007, AfCS ID A003961
Kubota, S, M. Takigawa 2007 -

Education (2)：

- 1990 Kyoto University Graduate School of Medicine
- 1986 Osaka University School of Dentistry School of Dentistry

Professional career (2)：

Ph. D (Medical Science) (Kyoto University)
D.D.S. (Osaka University)

Work history (13)：

2024/04 - 現在 Okayama University Dental School Dean
2016/10 - 現在 Osaka University School of Dentistry
2014/06 - 現在 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences Professor
2020/04 - 2024/03 日本学術振興会学術システム研究センター専門研究員
2020/04 - 2023/03 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences Vice Dean

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Committee career (14)：

2022 - 現在 Osteoarthritis and Cartilage (OARSI) Associate Editor
2020 - 現在日本学術振興会学術システム研究センター専門研究員
2018 - 現在 Journal of Oral Biosciences (歯科基礎医学会) Associate Editor
2017 - 現在日本軟骨代謝学会理事
2015 - 現在日本骨代謝学会評議員

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Awards (4)：

2017 - 科研費審査委員表彰
2012 - International CCN Society Research Promotion Award
2006 - 岡山歯学会優秀論文賞
1996 - Junior Investigator Award, Thomas Jefferson University

Association Membership(s) (10)：

日本歯科基礎医学会 , 日本癌学会 , 日本結合組織学会 , 日本骨代謝学会 , 日本分子生物学会 , International CCN Society , 日本生化学会 , 日本CCNファミリー研究会 , 日本軟骨代謝学会 , 岡山歯学会

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