Rchr
J-GLOBAL ID:200901054485643045
Update date: Jan. 14, 2025
Kasai Rinshi
Kasai Rinshi
Affiliation and department:
Homepage URL (1):
https://sites.google.com/view/kasai-rinshi-hp/home?authuser=0
Research field (2):
Bio-, chemical, and soft-matter physics
, Cell biology
Research keywords (8):
Planar Cell Polarity
, Super-resolution microscopy
, membrane protein
, 蛍光顕微鏡
, dimer
, G-protein coupled receptor
, 蛍光1分子観察
, membrane organization
Research theme for competitive and other funds (19):
- 2024 - 2027 パターン化人工膜とナノ空間を用いた細胞外小胞膜の再構成と膜タンパク質の解析
- 2024 - 2027 痛みの遷延化を引き起こす脳内多様性エピゲノム修飾解析とエピゲノム改善鎮痛薬の探索
- 2023 - 2025 細胞由来膜小胞を用いた、脂質間相互作用で制御される機能性リポソームの構築
- 2023 - 2024 再構成脂質膜基板を用いた、液中タンパク質-膜脂質間相互作用の1分子感度測定法の構築
- 2020 - 2023 Measuring molecular properties of membrane proteins using a synthetic cell micro-environment conposed of a model cell membrane and a nanometric space
- 2018 - 2023 Development of single-molecule methods measuring energy conversion processes of biological and synthetic molecular engines
- 2018 - 2023 Uncovering the secrets of lipid-transporting ABC proteins
- 2020 - 2021 Understanding the molecular mechanism of cell polarity: An approach by the single fluorescent molecule observation in live cell
- 2020 - 2021 2020 年度京都大学リサーチ・ディベロップメントプログラム
- 2020 - 2021 接着性GPCRを介した細胞間接着と極性形成の仕組みの解明
- 2018 - 2021 パターン化人工膜を用いたG蛋白質共役型受容体のラフト親和性と機能の解析
- 2017 - 2020 Evaluating the affinity of membrane proteins and lipid raft using a patterned model membrane platform
- 2017 - 2020 Dimerization-induced signal generation of GPCR: Single molecule observation in live cells
- 2014 - 2017 Evaluating the raftophilicity of membrane proteins in a patterned model membrane
- 2014 - 2017 Studies on the signal transduction mechanisms regulated by heterodimer formation of GPCR
- 2012 - 2015 Unraveling the formation mechanism of membrane macroscopic structures by single-molecule imaging
- 2012 - 2014 GPCRのシグナル伝達経路の分岐の仕組み:1分子観察法を用いた研究
- 2012 - 2014 Elucidating the function of GPCR dimerization by single-molecule observation
- 2012 - 2013 Meso-scale domains in the cell membrane for locally enhancing chemical reactions as revealed by single-molecule tracking of newly developed fluorescent probes
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Papers (38):
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Peng Zhou, Taka A. Tsunoyama, Rinshi S. Kasai, Koichiro M. Hirosawa, Ziya Kalay, Amine Aladag, Takahiro K. Fujiwara, Simone Pigolotti, Akihiro Kusumi. Single-molecule detection of transient dimerization of opioid receptors 1: Homodimers’ effect on signaling and internalization. 2024
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Peng Zhou, Rinshi S. Kasai, Wakako Fujita, Taka A. Tsunoyama, Hiroshi Ueda, Simone Pigolotti, Takahiro K. Fujiwara, Akihiro Kusumi. Single-molecule detection of transient dimerization of opioid receptors 2: Heterodimer blockage reduces morphine tolerance. 2024
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Nishiguchi, S., Kasai, R.S., Uchihashi, T. Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed-atomic force microscopy. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 18
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Taisei Yamamoto, Satoshi Yasuda, Rinshi S. Kasai, Ryosuke Nakano, Simon Hikiri, Kanna Sugaya, Tomohiko Hayashi, Satoshi Ogasawara, Mitsunori Shiroishi, Takahiro K. Fujiwara, et al. A methodology for creating mutants of G-protein coupled receptors stabilized in active state by combining statistical thermodynamics and evolutionary molecular engineering. Protein Science. 2022. 31. 10
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Rurika Nagai, Ayane Sugimachi, Yasushi Tanimoto, Kenichi G N Suzuki, Fumio Hayashi, Dorothee Weikert, Peter Gmeiner, Rinshi S Kasai, Kenichi Morigaki. Functional Reconstitution of Dopamine D2 Receptor into a Supported Model Membrane in a Nanometric Confinement. Advanced biology. 2021. 5. 12. e2100636
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MISC (42):
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岡本雄介, 永田紅, 笠井倫志, 木村泰久, 木岡紀幸, 木岡紀幸, 植田和光, 植田和光. ABCAサブファミリータンパク質のC末端領域の機能解明を目的としたキメラタンパク質の解析. 日本生化学会大会(Web). 2018. 91st
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岡本雄介, 永田紅, 笠井倫志, 楠見明弘, 楠見明弘, 木村泰久, 木岡紀幸, 植田和光, 植田和光. HDL産生の鍵を握るABCA1のC末端領域の機能解析. 日本農芸化学会大会講演要旨集(Web). 2016. 2016
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KASAI Rinshi. Dimers are the key trigger for the GPCR’s basic signaling without ligation. 2014
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Kasai Rinshi, Kusumi Akihiro. 2P104 Dimers are the key trigger for the GPCR's basic signaling without ligation(03. Membrane proteins,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)). Seibutsu Butsuri. 2014. 54. 1. S212
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Yuki Shirai, Peng Zhou, Rinshi Kasai, Wonhwa Cho, Takahiro Fujiwara, Akihiro Kusumi. 3P175 Single-molecule detection of hotspots for dynamic concentration of the kappa opioid receptor(Cell biology,Poster,The 52th Annual Meeting of the Biophysical Society of Japan(BSJ2014)). Seibutsu Butsuri. 2014. 54. 1. S278
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Patents (1):
Books (9):
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トクシュウ セイタイマク シンポジウム 「 セイタイマク ニ オケル セイメイ ゲンショウ ノ リカイ オ メザシテ : ブンシ カラ コタイ レベル マデ 」
2024
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Quantitative Biology: Dynamics of Living Systems
Frontiers Media SA 2017
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医学のあゆみ GPCR研究の最前線2016 企画 飯利太朗 槙田紀子
医歯薬出版株式会社 2016
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生体の科学 [増大特集] 生命動態システム科学
医学書院 2014
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現代化学
東京化学同人 2013
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Lectures and oral presentations (52):
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細胞内の分子がメゾスケールレベルで組織化する仕組みの解明
(2023)
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膜中でのGタンパク質共役型受容体のダイマー形成についての研究
(2023)
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qCMOSカメラを用いた蛍光1分子観察で、分子が働く仕組みを探る
(2023)
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1分子観察法による、メゾスケールでの分子の作動機構の解明
(2023)
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蛍光1分子観察法による細胞膜中の分子の動態と機能の解明:会合体形成とダイナミクス
(日本化学会秋季事業 第10回 CSJ化学フェスタ2020 2020)
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Education (3):
- 2000 - 2005 Nagoya University
- 1998 - 2000 Nagoya University
- 1994 - 1998 Kanazawa University Faculty of Science
Professional career (2):
- Master of Science (Nagoya University)
- Doctor of Science (Nagoya University)
Work history (11):
- 2024/04 - 現在 Hoshi University
- 2023/06 - 現在 National Cancer Center Research Institute Laboratory Head
- 2022/04 - 2024/03 Kyoto University
- 2021/04 - 2023/05 Gifu University
- 2021/04 - 2022/03 Kyoto University
- 2016/10 - 2021/03 Kyoto University Institute for Frontier Life and Medical Sicences Assistant Professor
- 2011/04 - 2021/03 Kyoto University
- 2013/01 - 2017/03 Kyoto University
- 2011/04 - 2016/09 Kyoto University Institute for Frontier Medical Sciences Assistant Professor
- 2010/04 - 2011/03 Kyoto University Institute for Integrated Cell-Material Sciences (iCeMS) Program-Specific Researcher
- 2005/04 - 2010/03 Japan Science and Technology Agency ICORP Researcher
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Committee career (1):
- 2010/01 - 現在 日本生物物理学会 分野別専門委員
Association Membership(s) (4):
アメリカ生物物理学会
, アメリカ細胞生物学会
, 日本細胞生物学会
, 日本生物物理学会
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