Rchr
J-GLOBAL ID:200901054640249952
Update date: Jun. 03, 2024
Kigoshi Hideo
キゴシ ヒデオ | Kigoshi Hideo
Affiliation and department:
Job title:
Specially Appointed Professor
Homepage URL (1):
http://www.chem.tsukuba.ac.jp/kigoshi/index.html
Research field (2):
Chemical biology
, Molecular biochemistry
Research keywords (8):
molecular mechanism of biological activity
, total synthesis
, structural determination
, isolation
, biologically active natural products
, Synthetic Organic Chemistry
, Bioorganic Chemistry
, Natural Product Chemistry
Research theme for competitive and other funds (23):
- 2020 - 2023 Study of Protein-Protein Interaction Induced by Marine Natural Products
- 2020 - 2022 Chemical Communication between Marine Natural Products and Cytoskeleton
- 2018 - 2020 Analysis and application of chemical communication of marine natural products and cytoskeletons
- 2014 - 2019 Study on Protein-Protein Interaction Induced by Marine Natural Products
- 2011 - 2016 Study on Molecular Mechanism of Cytotoxicity Concerning with Cytoskeleton
- 2011 - 2016 Chemical biology using natural products
- 2011 - 2014 Study on Molecular Mechanism of Cytotoxicity of Marine Natural Products
- 2008 - 2010 Study on novel modes of action of antitumor marine natural products
- 2006 - 2007 骨格筋タンパク質ミオシンと複合する新規海洋天然物の探索と創製
- 2004 - 2007 海洋産生物活性物質の合成と活性発現の分子機構
- 2001 - 2002 アクチン、ホスファターゼなどの生体高分子と複合する有機化合物の創製と反応
- 1999 - 2002 STUDIES ON SEARCH FOR ANTI-FOULING SUBSTANCES AND THEIR DEVELIPMENTS
- 1998 - 1999 Generation and Reactivity of DNA Cleaving Agents
- 1996 - 1996 DNA塩基配列認識部位を持つアルキル化分子の創製
- 1995 - 1995 発癌・抗癌物質によるDNAの修飾,切断の分子機構
- 1995 - 1995 DNA塩基配列認識部位を持つアルキル化分子の創製
- 1994 - 1994 DNA塩基配列認識部位を持つアルキル化分子の創製
- 1992 - 1994 Structures and Synthesis of Natural Antitumor/Carcinogenic Substances.
- 1992 - 1992 特異なアルキル化機能分子による核酸の選択的修飾・切断反応
- 1987 - 1988 Chemical Modification of Nucleic Acids and Related Substances with a Carcinogen Ptaquiloside.
- Isolation and Structure of Bioactive Natrural Organic Compounds
- Synthesis and Reaction of Bioactive Natural Organic Compounds
- Mechanism of Reactions of Bioactive Natural Organic Compounds toward Biomolecules
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Papers (223):
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Yoshida, Masahito, Okoshi, Yuhi, Kigoshi, Hideo. Concise total synthesis and structure revision of metacridamides A and B. CHEMICAL COMMUNICATIONS. 2023. 59. 65. 9880-9883
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Yoshida, Masahito, Inaba, Tetsuya, Shibuya, Yuko, Igarashi, Masayuki, Kigoshi, Hideo. Concise Total Synthesis and Biological Evaluation of Pargamicin A and its Diastereomer, Piperazic Acid-containing Cyclopeptides. CHEMPLUSCHEM. 2023. 88. 8
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Ohyoshi, Takayuki, Iizumi, Hidetada, Hosono, Shu, Tano, Hikaru, Kigoshi, Hideo. Total Synthesis of Aplysiasecosterols A and B, Two Marine 9,11-Secosteroids. ORGANIC LETTERS. 2023. 25. 25. 4725-4729
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Ohyoshi, Takayuki, Namiki, Mayu, Miyazaki, Yuto, Sato, Shusei, Noguchi, Tomonari, Kigoshi, Hideo. Toward the total synthesis of scytophycins: Synthesis of the C7-C21 fragments of scytophycins A, B, and C. TETRAHEDRON LETTERS. 2023. 114. EPub. 154250
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Ohyoshi, Takayuki, Zhao, Yiwen, Kigoshi, Hideo. Isolation and Synthesis of Azuriaplysins A and B, Bromoditerpenes with an a-Methylene Carbonyl from the Sea Hare Aplysia kurodai. JOURNAL OF NATURAL PRODUCTS. 2022. 85. 8. 2082-2089
more...
MISC (3):
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早川一郎, 木越英夫. ますます進化する天然物合成-実用的天然物合成の時代が見えてきた. 化学. 2012. 67. 6. 70-71
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早川一郎, 木越英夫. トリトンB. 有機合成化学協会誌. 2010. 68. 8. 870
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Sato, S, Murata, A, Orihara, T, Suenaga, K, Kigoshi, H, Uesugi, M. Isolating and identifying protein targets of marine natural product aurilide. The 4th iCeMS International Symposium: “Integrated Physical/Chemical Biology of the Cell: from Genes to Membrane Systems”, Kyoto, Japan. 2009
Patents (5):
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微小管重合阻害剤
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炎症性疾患治療剤及びその使用
-
新規サポニン化合物
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生理活性物質ビセライドA、ビセライドB及びビセライドC、それらの製造法並びにそれらの用途
-
高度の歪み構造を有するインゲナン骨格の合成に係わる方法
Books (16):
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DISCOVERY AND UTILITY OF CHEMICAL PROBES IN TARGET DISCOVERY
ROYAL SOC CHEMISTRY 2021 ISBN:9781839160745
-
Handbook of Anticancer Drugs from Marine Origin
Springer International Publishing Switzerland 2015 ISBN:9783319071442
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ウォーレン有機合成:逆合成からのアプローチ
東京化学同人 2014
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ソレル有機化学(下)
東京化学同人 2009
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ソレル有機化学(上)
東京化学同人 2009
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Lectures and oral presentations (84):
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p53-Hdm2相互作用阻害活性を示すSiladenoserinol Aの誘導体合成と生物活性評価
(日本化学会第103春季年会)
-
環状デプシペプチドLagunamide Cの合成研究
(日本化学会第103春季年会)
-
海洋産環状デプシペプチドBouillonamideの合成研究
(日本化学会第103春季年会)
-
細胞毒性環状デプシペプチドDestruxin Eの誘導体合成と生物活性評価
(日本化学会第103春季年会)
-
Pargamicin A誘導体の合成と生物活性
(日本化学会第103春季年会)
more...
Education (2):
- - 1983 Nagoya University Graduate School of Science Department of Chemisty
- - 1981 Nagoya University Faculty of Science
Professional career (1):
- D. Sc. (Nagoya University)
Work history (8):
- 2024/04 - 現在 University of Tsukuba Alliance for Research on the Mediterranean and North Africa Specially Appointed Professor
- 2011/10 - 2024/03 University of Tsukuba Faculty of Pure and Applied Sciences Professor
- 2004/04 - 2011/09 University of Tsukuba Graduate School of Pure and Applied Sciences Professor
- 2000/08 - 2004/03 University of Tsukuba Department of Chemistry Professor
- 1998/04 - 2000/07 Nagoya University Research Center for Materials Science Associate Professor
- 1996/04 - 1998/03 Nagoya University Graduate School of Science Associate Professor
- 1994/07 - 1996/03 Nagoya University Faculty of Science Associate Professor
- 1984/03 - 1994/06 Nagoya University Faculty of Science Assistant Professor
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Committee career (3):
- 2006/03 - 2013/02 日本化学会 欧文誌編集委員
- 2009/03 - 2011/02 有機合成化学協会 有機合成化学協会誌編集委員
- 2002/03 - 2005/02 日本化学会 速報誌編集委員
Awards (2):
- 1993 - 日本化学会進歩賞
- 1993 - 井上研究奨励賞
Association Membership(s) (4):
THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, THE CHEMICAL SOCIETY OF JAPAN
, American Chemical Society
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