Rchr
J-GLOBAL ID:200901055163308042
Update date: Dec. 15, 2025
Sakaguchi Masakiyo
サカグチ マサキヨ | Sakaguchi Masakiyo
Affiliation and department:
Job title:
Professor
Homepage URL (2):
https://www.okayama-u.ac.jp/user/cellbiol/
,
https://pxy-www.a.okayama-u.ac.jp/user/cellbiol/
Research field (3):
Tumor biology
, Physiology
, Molecular biology
Research keywords (12):
S100 protein
, REIC/DKK3
, Cancer-related inflammation and metastasis
, Antibody
, Gene expression technology
, Gene therapy
, Ligand-receptor signaling
, IPF
, Psoriasis
, Atopic dermatitis
, ANCA-associated vasculitis
, Inflammatory disease
Research theme for competitive and other funds (105):
Papers (223):
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Ikuko Miyazaki, Nami Isooka, Ryo Kikuoka, Fuminori Imafuku, Kaori Masai, Kana Tomimoto, Masakiyo Sakaguchi, Chiharu Sogawa, Norio Sogawa, Yoshihisa Kitamura, et al. Rotenone targets midbrain astrocytes to produce glial dysfunction-mediated dopaminergic neurodegeneration. Acta neuropathologica communications. 2025. 13. 1. 234-234
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Nang Thee Su Pwint, Chunning Li, Tong Gao, Yuze Wang, Masayoshi Fujisawa, Toshiaki Ohara, Masakiyo Sakaguchi, Teizo Yoshimura, Akihiro Matsukawa. Neurofibromin Encoded by the Neurofibromatosis Type 1 (NF1) Gene Promotes the Membrane Translocation of SPRED2, Thereby Inhibiting the ERK Pathway in Breast Cancer Cells. International journal of molecular sciences. 2025. 26. 20
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Youyi Chen, Xu Yang, Rie Kinoshita, Nahoko Tomonobu, Bo Pan, Fangping Wu, Xu Zhang, Kazumi Sagayama, Bei Sun, Masakiyo Sakaguchi. S100A8/A9-MCAM signaling promotes gastric cancer cell progression via ERK-c-Jun activation. In vitro cellular & developmental biology. Animal. 2025. 61. 9. 1082-1096
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Yoshifumi Saito, Sora Miyakawa, Shotaro Ando, Carlos Ichiro Kasano-Camones, I Wayan Sumardika, Akari Obayashi, Aoi Morimoto, Aya Kurosawa, Masakiyo Sakaguchi, Kazumi Ninomiya, et al. SALL1 functions as a tumor suppressor in hepatocellular carcinoma cells. Biochemical and biophysical research communications. 2025. 778. 152385-152385
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Yuto Naoi, Yumi Inukai, Tomoka Izumikawa, Joji Nagasaki, Takamasa Ishino, Youki Ueda, Yin Min Thu, Miho Fujiwara, Takahiro Baba, Go Makimoto, et al. Close Spatial Interactions between Cancer Cells and Cancer-Associated Fibroblasts Suppress Antitumor Immunity. Cancer immunology research. 2025. 13. 9. 1471-1484
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MISC (187):
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Emilie Llinares, Nahoko Tomonobu, Rie Kinoshita, Ken-ichi Yamamoto, Hitoshi Murata, Junichiro Futami, Yusuke Inoue, Shinichi Toyooka, Eisaku Kondo, Akira Yamauch, et al. Deciphering the Role of MCAM in Retinoic Acid Signaling and Metastatic Potential in Breast Cancer Cells. 2025
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Development of hyper gene expression plasmid vector for mammalian cells in a stable manner. 2025
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南杏莉, 阪口義彦, 武晃, 後藤和義, 松本可南子, 河口裕哉, 友信奈保子, 山本健一, 竹原正也, 塩見慎也, et al. Evaluation of the isolated Kanagawa-riverbed soil actinomycetes for their metabolites’ antibacterial activities. 日本薬学会年会要旨集(Web). 2025. 145th
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河口裕哉, 阪口義彦, 武晃, 後藤和義, 松本可南子, 南杏莉, 友信奈保子, 山本健一, 竹原正也, 塩見慎也, et al. Evaluation of the isolated Kanagawa-soil actinomycetes for its typical antibacterial and metabolites. 日本薬学会年会要旨集(Web). 2025. 145th
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阪口義彦, 武晃, 後藤和義, 松本可南子, 南杏莉, 河口裕哉, 友信奈保子, 山本健一, 竹原正也, 塩見慎也, et al. Analytical study of bioactive substances produced by the newly identified intestinal actinomycetes after the fecal microbial transplantation therapy. 日本薬学会年会要旨集(Web). 2025. 145th
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Patents (67):
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肺炎症性疾患の予防及び/又は治療剤
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化合物、神経系疾患の予防又は治療薬
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リン酸化SARM1、抗体、SARM1リン酸化阻害剤、神経変性疾患の予防又は治療薬、スクリーニング方法、SARM1改変体及び使用
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リン酸化SARM1、抗体、SARM1リン酸化阻害剤、神経変性患者の予防または治療薬、スクリーニング方法、SARM1改変体及び使用
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肺炎症性疾患の予防及び/又は治療剤
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Books (11):
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展望「10年間の歩みと現在の私」
小林がん学術振興会 2025
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S100タンパク質に着眼したがん転移機構の解明とその制御
岡山医学会雑誌 2018
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Elucidation and therapeutic applicaftion of the receptor family of S100A8/A9 that controls cancer sensing mechanism of its transition to destination organ
2018
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DAMPセンサーRAGEの多様な生理機能を生み出す信号伝達の最前線--RAGE信号伝達の新展開, 特集DAMPsと疾患、創薬
週刊「医学のあゆみ」 2018
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転移先臓器を感知する受容体群の分子制御機構の解明とその応用
月刊「細胞」 2017
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Lectures and oral presentations (113):
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REIC/Dkk-3 in cancer biology and its therapeutic potential for cancer
(The annual meeting hepatobiliary of Hunan -2024 2024)
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血漿多機能性タンパクの受容体探索同定法と創薬戦略
(第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会 2023)
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血漿タンパク受容体をターゲットとした創薬プラン
(第 44 回日本臨床薬理学会学術総会 2023)
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A tremendous therapeutic benefit of targeting strategy of S100A8/A9 on metastatic prevention of cancers
(The annual meeting hepatobiliary of Hunan -2023 2023)
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がん転移におけるS100A8/A9の機能解明とその制御 ーHRGの発見による新展開ー
(がん転移におけるS100A8/A9の機能解明とその制御 ーHRGの発見による新展開ー 2022)
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Education (1):
- 1997 - 2001 Okayama University
Professional career (1):
- Doctor of Philosophy in Medical Science (Okayama University)
Work history (8):
- 2021/04 - 現在 Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Cell Biology Professor
- 2018/07 - 2021/03 Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Cell Biology Professor
- 2014/01 - 2018/06 Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Cell Biology Associate Professor
- 2008/05 - 2013/12 Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Cell Biology Associate Professor
- 2007/04 - 2008/04 Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Cell Biology Assistant Professor
- 2005/04 - 2007/03 Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Cell Biology Research Associate
- 2004/04 - 2005/03 Okayama University, Graduate School of Medicine, Dentistry Cell Biology Research Associate
- 2001/04 - 2004/03 JSPS Research Fellowship for Young Scientists (PD)
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Committee career (5):
- 2024/04 - 現在 日本組織培養学会 評議員
- 2020/01 - 現在 日本癌学会 評議員
- 2023/08 - 2023/09 日本組織培養学会第95回大会 大会長
- 2017/07 - 2017/07 日本組織培養学会第90回大会 プログラム 運営委員
- 2004 - 日本組織培養学会 大会運営補助
Awards (10):
- 2025/03 - In Vitro Cellular & Developmental Biology - Animal (Springer Nature) The Springer Nature Editor of Distinction Award
- 2022/04 - 公益財団法人長瀬科学技術振興財団 長瀬研究振興賞
- 2021/03 - Acta Medica Okayama Best Reviewer Award
- 2017/06 - 岡山大学 医学賞(結城賞)
- 2017/05 - ウエスコ財団 優秀研究者賞
- 2014/05 - 公益財団法人山陽放送学術文化財団 医歯薬学分野学術奨励賞
- 2010/01 - 岡山大学 若手トップリサーチャー研究奨励賞
- 2003/07 - American Association for Cancer Research (AACR) ITO-EN, Ltd. Scholar-in-Training Award
- 2001/06 - 岡山大学 医学賞(結城賞)
- 2000/06 - American Society for In Vitro Biology (SIVB) Student Award
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Association Membership(s) (3):
The Japanese Tissue Culture Association
, The Japanese Cancer Association
, American Association for Cancer Research
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