Hirata Yoko

モリタヨウコ | Hirata Yoko

Affiliation and department：
Homepage URL (1)： https://www1.gifu-u.ac.jp/~bioinfo1/Bioinfo1/BIoinfo1.html

Research field (3)： Neurology , Cell biology , Neuroscience - general

Research keywords (14)： Ferroptosis , Sigma receptors , ER stress , Oxidative stress, Oxytosis, Ferroptosis , Dopaminergic Neurotoxins , Neuroprotective Compounds , Neurotrophic Factors , Parkinson's Disease , Neurodegeneration , ドーパミン神経毒 , 神経保護物質 , アポトーシス , 神経変性疾患 , パーキンソン病

Research theme for competitive and other funds (21)：

2022 - 2025 Development of feroptosis inhibitors based on the novel antioxidative mechanism
2023 - 2024 Verification of the Profile of a Novel Ferroptosis Inhibitors
2022 - 2023 リソソーム局在化合物の神経保護作用
2021 - 2022 新規神経保護化合物N,N-ジメチルアニリン誘導体の酸化ストレス誘導性細胞死抑制機構の解明
2017 - 2018 神経変性疾患に有効な神経保護化合物の開発

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Papers (138)：

Yoko Hirata, Hiroshi Takemori, Kyoji Furuta, Yuji O. Kamatari, Makoto Sawada. Ferroptosis induces nucleolar stress as revealed by live-cell imaging using thioflavin T. Current Research in Pharmacology and Drug Discovery. 2024. 7. 100196-100196
Ayumi Sakurai, Kyoka Kawaguchi, Miyu Watanabe, Sayaka Okajima, Saho Furukawa, Kenichi Koga, Kentaro Oh-Hashi, Yoko Hirata, Kyoji Furuta, Hiroshi Takemori. Melanosomal localization is required for GIF-2115/2250 to inhibit melanogenesis in B16F10 melanoma cells. International Journal of Cosmetic Science. 2024
Saho Furukawa, Kyoka Kawaguchi, Kotomi Chikama, Ryohei Yamada, Yuji O. Kamatari, Lee Wah Lim, Hiroko Koyama, Yasuo Inoshima, Mitsushi J. Ikemoto, Saishi Yoshida, et al. Simple methods for measuring milk exosomes using fluorescent compound GIF-2250/2276. Biochemical and Biophysical Research Communications. 2024. 149505-149505
Yoko Hirata, Tomohiro Hashimoto, Kaori Ando, Yuji Kamatari, Hiroshi Takemori, Kyoji Furuta. Structural features localizing the ferroptosis inhibitor GIF-2197-r to lysosomes. RSC Advances. 2023. 13. 46. 32276-32281
Akane Kanamori, Shohei Hinaga, Yoko Hirata, Fumimasa Amaya, Kentaro Oh-Hashi. Molecular characterization of wild-type and HSAN2B-linked FAM134B. Molecular biology reports. 2023. 50. 7. 6005-6017

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MISC (8)：

高島茂雄, 武本詳子, 豊吉佳代子, 大場亜希子, 藤田遥, 大橋憲太郎, 森田洋子, 下澤伸行. ペルオキシソーム形成異常症モデルゼブラフィッシュの作出と表現型解析. 日本先天代謝異常学会雑誌. 2017. 33. 225-225
Tatsuhide Tanaka, Kentaro Oh-hashi, Hironobu Shitara, Yoko Hirata, Kazutoshi Kiuchi. Analysis of regulatory mechanisms of LPS-induced GDNF gene expression in primary cultured glial cells. NEUROSCIENCE RESEARCH. 2007. 58. S149-S149
Hirohide Sawada, Ryohei Hishida, Yoko Hirata, Kenji Ono, Hiromi Suzuki, Shin-ichi Muramatsu, Imaharu Nakano, Kunihiro Tsuchida, Toshiharu Nagatsu, Makoto Sawada. Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with MPTP. NEUROSCIENCE RESEARCH. 2006. 55. S201-S201
Y HIRATA, T NAGATSU. INHIBITION OF TYROSINE HYDROXYLATION IN RAT STRIATAL TISSUE-SLICES BY 1-METHY-4-PHENYLPYRIDINIUM ION (MPP+)-RELATED COMPOUNDS. NEUROCHEMICAL RESEARCH. 1986. 11. 12. 1746-1746
Y. Hirata, T. Nagatsu. Mechanism of induction of parkinsonism by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a dopaminergic neurotoxin. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 1986. 31. 5. 398-409

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Patents (4)：

化合物、細胞外小胞染色剤、および、細胞外小胞の蛍光染色方法
リソソーム局在性鉄イオンキレート剤、リソソーム局在性フェロトーシス阻害剤、抗酸化剤細胞保護方法
化合物、細胞性小胞染色剤および細胞性小胞の蛍光染色方法
タンパク質凝集抑制剤

Books (5)：

Tyrosine hydroxylase : Biochemical properties and short-term regulation in vitro and in vivo
"Pharmacology of Endogeneous Neurotoxins" ed. by A. Moser, Birkhauser, Boston 1998
The nerve growth factor family (共著)
"Growth Factors and Cytokines in Health and Disease", JPI Press Inc. 1996
Abnormality of central monoaminergic neurons in spontaneously hypertensive rats : In vitro and in vivo(voltammetry) studies (共著)
"Brain and blood pressure control" ed. by K. Nakamura, Elsevier, Amsterdam 1986
Elucidation of hydroxylases by calmodulin antagonists (共著)
"Calmodulin Angagonists and Cellular Physiology" eds. H.Hidaka and D.J.Hartshorne, Academic Press, New York 1985
Receptor-mediated mutual regulation of tyrosine hydroxylase activity and the biopterin cofactor level (共著)
"Progress in Bioorganic Chemistry and Molecular Biology" eds. Yu.A. Ovchinnikov, Elsevier, Amsterdam 1984

Works (2)：

Role of caspase and Bcl-2 protein in manganese-induced apoptosis in PC12 cells
2001 -
Characterization of NGFI-B kinase activity in rat brain
1994 - 1999

Professional career (1)：

Ph.D. (Tokyo Institute of Technology)

Work history (7)：

2013/07 - 2023/03 Gifu University Faculty of Engineering Professor
2000/07 - 2013/06 Gifu University Associate Professor
1994 - 2000 理化学研究所フロンティア研究員
1989 - 1994 米国国立衛生研究所 Visiting Associate
1986 - 1989 Nippon Medical School

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Committee career (2)：

2014 - 現在日本神経化学会評議員
2019/06 - 2021/03 愛知学院大学歯学研究科自己点検・評価委員

Association Membership(s) (4)：

北米神経科学会 (Society for Neuroscience) , 日本神経化学会 , 日本生化学会 , American Chemical Society

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