Isao Ishii

イシイイサオ | Isao Ishii

Affiliation and department：
Job title： Professor

Research field (5)： Molecular biology , Pharmacology , Pharmaceuticals - health and biochemistry , Pathobiochemistry , Medical biochemistry

Research theme for competitive and other funds (7)：

2016 - 2019 Novel molecular mechanisms of actions of homocysteine, a risk factor of cardiovascular diseases
2016 - 2018 Mechanism of food rejection upon amino acid-unbalanced diet
2013 - 2016 Functional relationship between metabolism of sulfur-containing amino acids and cardioprotection from ischemia-reperfusion injury
2011 - 2013 遺伝子改変マウスを利用したタンパク質チオール基化学修飾に基づく病態の検討
2010 - 2012 Pathophysiological analysis of acute muscle atrophy by failure of cysteine biosynthesis and development of its control strategy

Show all

Papers (120)：

Shotaro Kamata, Akihiro Honda, Nonoka Kashiwagi, Ayumi Shimamura, Sayaka Yashiro, Yuna Komori, Aoi Hosoda, Noriyuki Akahoshi, Isao Ishii. Different Coactivator Recruitment to Human PPARα/δ/γ Ligand-Binding Domains by Eight PPAR Agonists to Treat Nonalcoholic Fatty Liver Disease. Biomedicines. 2024
Kazuo Kajita, Isao Ishii, Ichiro Mori, Motochika Asano, Masayuki Fuwa, Hiroyuki Morita. Sphingosine 1-Phosphate Regulates Obesity and Glucose Homeostasis. International journal of molecular sciences. 2024. 25. 2
Sumeet Manandhar, Stephen Chambers, Andrew Miller, Isao Ishii, Madhav Bhatia. Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells. International Journal of Molecular Sciences. 2023
Shotaro Kamata, Akihiro Honda, Isao Ishii. Current Clinical Trial Status and Future Prospects of PPAR-Targeted Drugs for Treating Nonalcoholic Fatty Liver Disease. Biomolecules. 2023
Shotaro Kamata, Akihiro Honda, Ryo Ishikawa, Makoto Akahane, Ayane Fujita, Chihiro Kaneko, Saeka Miyawaki, Yuki Habu, Yui Shiiyama, Kie Uchii, et al. Functional and Structural Insights into the Human PPARα/δ/γ Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor. Antioxidants. 2023

ｍore...

MISC (22)：

Shotaro Kamata, Isao Ishii. PPARα-ligand binding modes revealed by x-ray crystallography. Yakugaku Zasshi. 2021. 141. 11. 1267-1274
秋山雅博, 鵜木隆光, 新開泰弘, 石井功, 山本雅之, 赤池孝章, 熊谷嘉人. Nrf2とCSEはメチル水銀中毒症状を抑制する鍵分子である. 衛生薬学・環境トキシコロジー講演要旨集. 2018. 2018
AKIYAMA Masahiro, UNOKI Takamitsu, WARABI Eiji, SHINKAI Yasuhiro, ISHII Isao, AKAIKE Takaaki, KUMAGAI Yoshito. Reactive sulfur species: protective role against electrophilic stress and reductive stress mediated by its intracellular excess accumulation. Annual Meeting of the Japanese Society of Toxicology. 2018. 45. 0. S10-3
SHINKAI Yasuhiro, AKIYAMA Masahiro, UNOKI Takamitsu, ISHII Isao, KUMAGAI Yoshito. The capture of cadmium by reactive polysulfides attenuates cadmium-induced hepatotoxicity. Annual Meeting of the Japanese Society of Toxicology. 2018. 45. 0. P-104
SHINKAI Yasuhiro, AKIYAMA Masahiro, UNOKI Takamitsu, ISHII Isao, KUMAGAI Yoshito. Capture of cadmium by reactive persulfides/polysulfides attenuates cadmium-induced adaptive responses and hepatotoxicity. Annual Meeting of the Japanese Society of Toxicology. 2017. 44. 0. P-274

ｍore...

Books (8)：

RSSの生合成系とタンパク質機能制御
学研メディカル秀潤社 2015
ホモシステイン血症再考
日本生化学会 2013
Methionine: Biosynthesis, Chemical Structure and Toxicity.
Nova Science Publishers, Inc. 2013 ISBN:9781626182462
システイン生合成経路の破綻による病態
日本アミノ酸学会 2007
分子栄養学の基礎
第一出版 2006

ｍore...

Lectures and oral presentations (43)：

心虚血再灌流障害におけるホモシステインの新規作用機序
(第38回日本分子生物学会年会・第88回日本生化学会大会合同年会 2015)
絶食によるマウス臓器タンパク質リモデリングの網羅的プロテオーム解析
(第38回日本分子生物学会年会・第88回日本生化学会大会合同年会 2015)
Cytathionine β synthase is required to maintain glutathione hydropersulfide, a novel antioxidant molecule, in the murine lens
(10th World Congress for Microcirculation 2015)
短期絶食によるマウス全身性応答1(臓器別遺伝子発現変化)
(第59回日本薬学会関東支部大会 2015)
短期絶食によるマウス全身性応答2(臓器別タンパク質発現変化)
(第59回日本薬学会関東支部大会 2015)

ｍore...

Awards (13)：

Show all

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page