Kaneda Yasufumi

2014 - 2017 Functional screening for novel molecules related to endothelial dysfunction in the ubiquitin system and the potential of their clinical application.

2014 - 2017 化学療法に対する抵抗性を克服することを目的とした希少がん(悪性胸膜中皮腫)治療薬開発のための医師主導治験の実施

2014 - 2016 CRISPR/Cas9法を用いた多能性維持遺伝子破壊による癌幹細胞形成能の探索

2013 - 2016 癌間質を標的とした抗腫瘍ウイルス封入血小板ベクターによる癌標的治療の新戦略

2012 - 2015 Analysis for novel function of alpha-synuclein in the endothelium and its clinical significance

2010 - 2015 ヒト癌細胞におけるHVJ-E作用機構の解明とがん治療臨床研究の実現

2012 - 2014 ストレス応答に基づく癌細胞の多能性獲得と破綻の分子機構の解明

2010 - 2013 不活化ウイルス粒子による癌治療臨床研究を基に機能補充した多角的癌遺伝子治療の開発

2011 - 2013 Development of novel formulation to make possible to multidisciplinary cancer-therapy with anti-cancer drugs, thermic, and immune treatment.

2009 - 2011 Development of the new cell-free device for sever heart failure by restructuring of artificial stem cell niche using extracellular matrixes and stem cell recruitment/differentiation factors

2009 - 2010 ヒストンH3メチル化酵素Whsc1による転写ネットワーク制御

2008 - 2009 制御性T細胞の抑制と腫瘍特異的な薬物送達を可能にするVirosomeの開発

2005 - 2006 Transcriptional regulation of osteogenesis using siRNA and its application to bone formation

2003 - 2004 Suppression of hepatic ischemia/reperfusion injury by early expression of protective protein

2003 - 2004 Development of gene therapy model for implantation failure patients using transient gene transfer to uterine endometrium

2003 - 2004 Development of anti-cancer strategy to increase sensitivity of cancer cells to chemotherapy using siRNA combined with HVJ-E vector

2001 - 2004 導入遺伝子の長期発現増強法を用いた転移性癌の遺伝子治療法の開発

2001 - 2002 Prevention of joint contracture following joint immobilization using gene therapy's method

2001 - 2002 Suppression of hepatic ischemia/reperfusion injury using RNA

2001 - 2002 Development of slow release reagent of NFkB decoy oligodeoxynucleotides for the treatment of rheumatic arthritis

2000 - 2001 Control of Ocular Proliferation and Neuroprotection by Gene Therapy and Analysis of These Molecular Mechanisms.

1999 - 2001 Application of In vivo Gene Transfer for the Analysis of Pathophysiology and Treatment in the Cardiovascular Disease

2000 - 2000 癌遺伝子治療のための新たな遺伝子発現増幅系の開発

1999 - 2000 Gene therapy for occular neovascularization.

1999 - 2000 Researches on novel techniques of organ-selective gene therapy in thoracic surgery

1999 - 2000 Regulation of Vascular Remodeling by Gene Transfer and Its Clinical Application : Exploration of Novel Gene Transfer Vector and Gene Therapy for Atherosclerosis, Angiogenic Diseases and Organ Infarction

1998 - 2000 Development of strategies of gene therapy for renal diseases

1998 - 2000 Gene therapy for progressive renal diseases

1997 - 2000 Gene therapy for cardiovascular diseases : Development of newvector and evaluation of clinical strategy

1999 - 1999 がん遺伝子治療ベクターの基礎研究

1998 - 1999 Application of HVJ liposome for creating the next generation of animal models for human diseases.

1998 - 1999 Gene Therapy and Transplantation of Retinal Pigment Epithelium for Ocular Proliferative Deseases and Retinal Degeneration

1998 - 1999 Basic study of correction of mutated gene in xeroderma pigmentosum group A

1998 - 1999 Development of gene therapy to myocardium using transvenous gene transfection method.

1998 - 1999 Effective treatment of HGF for chronic rejection after living renal transplantation

1997 - 1998 Isolation and characterization of tumor-specific antigen toward cancer gene therapy

1997 - 1998 Gene Therapy in the Cardiovascular Disease

1997 - 1997 がん遺伝子治療の基礎的研究

1996 - 1997 A novel gene therapy for congestive heart failure.

1996 - 1997 Development of Gene Therapy for Familial Hypercholesterolemia-in vivo gene transfer to hepatocytes by HVJ-liposome-retrovirus method-

1996 - 1997 Development of Gene Therapy for Progrssive Glomerular Diseases

1995 - 1997 Establishment of in vivo direct gene transfer system into joint using HVJ-liposome

1996 - 1996 標的遺伝子組換えによる突然変異体の作成とその生体機能の研究

1995 - 1996 Development of new DDS to individual organs by means of cell technology and its opplication to treatment of human diseases

1994 - 1996 A novel myocardial protection with in vivo gene transfection

1995 - 1995 モデルマウスを用いたDuchenne型筋ジストロフィーの遺伝子治療の試み

1994 - 1995 Development of Therapy for Refractory Hyperlipidemia with LDL Receptor Gene Introduction by Lipofection Method

1994 - 1994 in vivo遺伝子導入法を用いた血管作動性物質の糸球体障害への影響の検討

1994 - 1994 Duchenne型筋ジストロフィーの遺伝子治療の試み-mdxマウスを用いて-

1994 - 1994 生体組織への遺伝子導入法を用いたがん治療の基礎研究

1993 - 1994 Joint Study on the Therapy of Diseases by Gene Transfer

1993 - 1993 In vivo遺伝子導入による糸球体腎炎モデルの作製

1993 - 1993 Duchenne型筋ジストロフィーの遺伝子治療の試み-mdxマウスを用いて-

1993 - 1993 動物細胞での相同組換え頻度をあげる分子の細胞内導入と導入法の開発

1993 - 1993 Gunnラットへの遺伝子導入による先天性黄疸の解明と治療の基礎研究

1993 - 1993 臓器への遺伝子導入による細胞増殖の誘発と制御に関する研究

1993 - 1993 色素性乾皮症の修復欠損に関する遺伝子とタンパクの異常

1991 - 1993 Gene diagnosis and establishment of mice model for xeroderma pigmentosum group A

1992 - 1992 臓器への遺伝子導入法を用いた糖尿病治療の基礎研究

1992 - 1992 動物細胞での相同組換之頻度をあげる分子の細胞内導入と導入法の開発

1992 - 1992 Gunnラットへの遺伝子導入による先天性黄疸の解明と治療の基礎研究

1989 - 1992 Introduction of the foreign genetic information into tissue cells of living animals and its application to the medical science.

1991 - 1991 動物細胞での相同組換え頻度をあげる分子の細胞内導入と導入法の開発

1991 - 1991 遺伝子病研究のための新しい遺伝子導入・発現法の開発

1991 - 1991 臓器細胞へのがん遺伝子導入による生体での発癌機構の解明

1990 - 1990 新しい遺伝子導入法を応用したヒト染色体の安定化に必要なDNA構造の研究

1988 - 1988 核構成々分のモノクローナル抗体の細胞内注入による細胞複製機構の研究

1987 - 1988 Analysis of diphtheria toxin receptor by molecular cloning.

1987 - 1987 核構成々分のモノクローナル抗体の分離とその細胞内注入による細胞複製機構の解析

1985 - 1987 Basic studies on treatment of abnormal cells by introduction of active macromolecules into cells.

Basic Rerearch for Gene Therapy