1999 - 2001 Application of plasma proteins as blood substitutes
1999 - 2000 Design and Evaluation of Albumin Mutants for Clinical Application
1998 - 2000 Design and Functional Evaluation of Albumin Mutants for Improving Medicinal Efficacy
1997 - 1999 Topology Analysis of Drug Binding Sites on Serum Proteins using Photoaffinity Labeling Techniques
1997 - 1998 病態時における薬物の血清蛋白結合の分子機能学的動態解析
1995 - 1997 Development of Pharmaceutical Additives-Evaluation of Protein and Polysaccharide Hydrolysates as Carrier to Enhance Absorption Rate of Drug
1994 - 1995 Microenviromental Analysis of Drug Binding Site on Albumin by Point-mutation and Using Probe
1990 - 1991 Microenvironmental Analysis of Drug Binding Sites on Human Serum Albumin and alpha_1-Acid Glycoprotein
化学修飾化による薬物の生体内挙動の改善と生体反応の修飾
天然高分子を利用した薬物の製剤設計
薬物の血清蛋白結合に関する研究
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Papers (843)：
Koji Nishi, Yoshifumi Arimura, Naho Suetsugi, Takuro Beppu, Kaho Takasaki, Ayano Tamori, Ryo Kanda, Shuhei Imoto, Hirotaka Murase, Kenji Tsukigawa, et al. Ibuprofen-derived nitric oxide donors with a high affinity to human serum albumin induce cell death in pancreatic cancer cells through a non-caspase 3/7-mediated pathway. Biomedical reports. 2024. 21. 5. 159-159
Hiroki Yanagisawa, Hitoshi Maeda, Isamu Noguchi, Motohiko Tanaka, Naoki Wada, Taisei Nagasaki, Kazuki Kobayashi, Gai Kanazawa, Kazuaki Taguchi, Victor Tuan Giam Chuang, et al. Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein kinase activity and inhibiting Kupffer cell activation. Redox Biology. 2024. 76. 103314-103314
Koji Nishi, Ryo Kanda, Kaho Takasaki, Ayano Tamori, Yoshifumi Arimura, Shuhei Imoto, Hirotaka Murase, Kenji Tsukigawa, Masaki Otagiri, Keishi Yamasaki. Novel Diclofenac-NO Donor With High Affinity for Human Serum Albumin Induces Endoplasmic Reticulum Stress-mediated Cell Death in Human Pancreatic Cancer Cells. Anticancer research. 2024. 44. 9. 3793-3798
Kazuaki Taguchi, Mai Hashimoto, Masahiro Tokuno, Shinji Takeoka, Toru Maruyama, Keishi Yamasaki, Masaki Otagiri. Qualitative and quantitative status of cytochrome P450s after the administration of a liposomal platelet substitute in rat liver. Xenobiotica; the fate of foreign compounds in biological systems. 2024. 1-7
Akito Kawai, Keishi Yamasaki, Masaki Otagiri, Yohei Doi. Interaction of Cephalosporins with Human Serum Albumin: A Structural Study. Journal of Medicinal Chemistry. 2024
Ishima Yu, Maruyama Toru, Otagiri Masaki, Chuang Victor T G, Ishida Tatsuhiro. The new delivery strategy of albumin carrier utilizing the interaction with albumin receptors. Chemical & Pharmaceutical Bulletin. 2022. Vol.70. No.5. 330-333
Kazuaki Taguchi, Yuko Okamoto, Kazuaki Matsumoto, Masaki Otagiri, Victor Tuan Giam Chuang. When albumin meets liposomes: A feasible drug carrier for biomedical applications. Pharmaceuticals. 2021. 14. 4
Kazuaki Taguchi, Kazuaki Matsumoto, Toru Maruyama, Masaki Otagiri. Strategy of drug development based on the bioactive gas-carrying capacity of hemoglobin. Yakugaku Zasshi. 2020. 140. 2. 141-146
Akito Kawai, Keishi Yamasaki, Masaki Otagiri. Structure study of human serum albumin complexed with aripiprazole. Photon Factory Activity Report 2018. 2019. #36
