Rchr
J-GLOBAL ID：200901055874377900   Update date: Sep. 11, 2024

Unoki Motoko

ウノキ モトコ | Unoki Motoko
Affiliation and department：
The University of Tokyo Graduate School of Medicine Department of Human Genetics

About The University of Tokyo Graduate School of Medicine Department of Human Genetics


Job title： Associate Professor
Homepage URL  (2)： http://www.humgenet.m.u-tokyo.ac.jp/index.html ,  http://www.humgenet.m.u-tokyo.ac.jp/index.en.html
Research field  (6)： Developmental biology ,  Genetics ,  Medical biochemistry ,  Tumor biology ,  Cell biology ,  Molecular biology
Research keywords  (14)： non-homologous end joining ,  HELLS ,  CDCA7 ,  DNA repair ,  methylation ,  Hydroxylysine ,  acetylation ,  ICF syndrome ,  hydroxylation ,  UHRF1 ,  Histone modification ,  DNA methylation ,  Epigenetics ,  Carcinogenesis
Research theme for competitive and other funds  (24)：
  • 2023 - 2027 長鎖シークエンス技術を用いた腫瘍の転写産物全長の解析
  • 2023 - 2027 長鎖シークエンス技術を用いた腫瘍の転写産物全長の解析
  • 2023 - 2026 哺乳類におけるペリセントロメア非コードRNAを介した新しいDNAメチル化機構の解明
  • 2024 - 2025 2024年度東京大学女性研究者スキルアップ支援
  • 2019 - 2024 Mechanisms underlying maintenance of genome integrity by DNA methylation
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Papers (51)：
  • Masatomo So, Misaki Ono, Shigeki Oogai, Minako Kondo, Kaede Yamazaki, Charlotte Nachtegael, Hiroshi Hamajima, Risa Mutoh, Masaki Kato, Hisaya Kawate, et al. Inhibitory effects of extracts from Eucalyptus gunnii on α-synuclein amyloid fibrils. Bioscience, Biotechnology, and Biochemistry. 2024
  • Motoko Unoki, Shuhei Uemura, Akihiro Fujimoto, Hiroyuki Sasaki. The maternal protein NLRP5 stabilizes UHRF1 in the cytoplasm: implication for the pathogenesis of multilocus imprinting disturbance. Human Molecular Genetics. 2024. 33. 18. 1575-1583
  • Motoko Unoki. Exploring the intersection of epigenetics, DNA repair, and immunology from studies of ICF syndrome, an inborn error of immunity. Frontiers in Immunity. 2024. 15. 1405022
  • Kugui Yoshida-Tanaka, Ko Ikemoto, Ryoji Kuribayashi, Motoko Unoki, Takako Takano, Akihiro Fujimoto. Long-read sequencing reveals the complex structure of extra dic(21;21) chromosome and its biological effects. Human Genetics. 2023. 142. 9. 1375-1384
  • Shuhei Uemura, Shoji Maenohara, Kimiko Inoue, Narumi Ogonuki, Shogo Matoba, Atsuo Ogura, Mayuko Kurumizaka, Kazuo Yamagata, Jafar Sharif, Haruhiko Koseki, et al. UHRF1 is essential for proper cytoplasmic architecture and function of mouse oocytes and derived embryos. Life Science Alliance. 2023. 6. 8. e202301904-e202301904
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MISC (15)：
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Books (18)：
  • 疾患原因遺伝子・タンパク質の解析技術と創薬/診断技術への応用
    技術情報協会 2022 ISBN:9784861048777
  • ゲノム・エピゲノムインテグリティーを守護する蛋白質 -ICF症候群研究から見えてきたCDCA7/HELLSクロマチンリモデリング 複合体の役割-
    ニューサイエンス社 月刊「細胞」 8月号 2021
  • エピゲノムで新たな解明が進む「先天性疾患」
    メディカルドゥ 2021 ISBN:9784909508119
  • Understand better the Epigenetics!
    2020 ISBN:9784758122078
  • Recent insights into the chromatin remodeling and chromosome stability from studies of ICF syndrome
    2020
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Lectures and oral presentations  (142)：
  • Elucidation of the molecular pathogenesis of congenital diseases with DNA methylation abnormalities
    (The Genetics Society of Japan 96th Annual Meeting 2024)
  • Transcriptome analysis of adult T-cell leukemia using long-read sequencing technology
    (2024)
  • The maternal protein NLRP5 stabilizes UHRF1 in the cytoplasm: Implication for the pathogenesis of multilocus imprinting disturbances
    (The 17th Annual Meeting of the Japanese Society for Epigenetics 2024)
  • 三毛猫の毛色をつかさどる遺伝子の探索 〜60年間の謎に挑む〜
    (コンパニオンアニマルのゲノム医療研究会 第4回研究会 2024)
  • DNA methylation safeguards genome stability: Insights from ICF syndrome studies
    (The 46th Annual Meeting of the Molecular Biology Society of Japan 2023)
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Education (1)：
  • 1999 - 2003 The University of Tokyo Graduate School of Medicine Pathology, Immunology, Microbiology,
Professional career (1)：
  • Ph.D. (The University of Tokyo)
Work history (7)：
  • 2022/09 - 現在 The University of Tokyo Department of Human Genetics Associate Professor
  • 2019/09 - 2022/08 Medical Institute of Bioregulation, Kyushu University Division of Epigenomics and Development, Associate professor
  • 2010/10 - 2019/08 Kyushu University Epigenomics and development Assistant Professor
  • 2008/05 - 2010/09 RIKEN Postdoctoral fellow
  • 2004/05 - 2008/04 National Cancer Institute (NIH) Postdoctoral fellow
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Committee career (10)：
  • 2024/01 - 現在 The Japan Society of Human Genetics Members of the Research Promotion Committee
  • 2023/06 - 現在 東京大学 疾患生命工学センター動物実験施設運営小委員会委員
  • 2023/04 - 現在 Genes & Genetic Systems Editorial Board
  • 2023/04 - 現在 東京大学 医学部動物実験委員会委員
  • 2015/05 - 現在 Kyushu University Board member of Kyushu University Specially Certified Committee for Regenerative Medicine
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Awards (5)：
  • 2024/07 - 日本遺伝学会 2024年度日本遺伝学会奨励賞 DNAメチル化異常を伴う先天性疾患の分子病態メカニズムの解明
  • 2015/09 - 内藤記念科学振興財団 The 40th Naito Conference Best poster award
  • 2013/08 - 第25回高遠シンポジウム優秀ポスター賞
  • 1999/03 - 日本獣医師会 日本獣医師会賞
  • 1994/03 - 竹岸・越智賞
Association Membership(s) (6)：
The Genetics Society of Japan ,  The Japan Society of Human Genetics ,  The molecular biology society of Japan ,  The Japanese Society for Epigenetics ,  American Association for Cancer Research ,  Japanese Cancer Association
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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