Rchr
J-GLOBAL ID：200901056331053795   Update date: Apr. 24, 2024

Takanori Eguchi

エグチ タカノリ | Takanori Eguchi
Affiliation and department：
Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences

About Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences


Job title： Associate Professor
Homepage URL  (1)： https://scholar.google.com/citations?hl=en&user=d37h9nQAAAAJ&view_op=list_works&sortby=pubdate
Research field  (4)： Tumor biology ,  Nutrition and health science ,  Hygiene and public health (laboratory) ,  Oral medicine (pathology)
Research keywords  (15)： Intercellular Communication ,  Exosome ,  Extracellular Vesicles ,  Extracellular Particle ,  RNA ,  Non-coding RNA ,  Protein ,  Gene expression control ,  Organoid ,  3D culture systems ,  Tumoroids ,  Moonlighting Proteins ,  Omics ,  Cancers ,  Cellular and Molecular Biology
Research theme for competitive and other funds  (41)：
  • 2023 - 2026 Roles of cancer extracellular vesicles in hijacking macrophages and metastatic niche formation
  • 2022 - 2026 Molecular mechanisms of the inhibition of placenta and fetus development induced by periodontal disease
  • 2023 - 2025 腫瘍微小環境の細胞間コミュニケーションにおけるMMP3含有エクソソームの機能解明
  • 2024 - 2025 Development of In Vitro Diagnostic Agents for Intractable Cancer Using Extracellular Vesicles
  • 2022 - 2025 Understanding MMP3-rich exosomes on neoplastic cell communication in tumor microenvironment
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Papers (131)：
  • Matthias P Mayer, Laura Blair, Gregory L Blatch, Thiago J Borges, Ahmed Chadli, Gabriela Chiosis, Aurélie de Thonel, Albena Dinkova-Kostova, Heath Ecroyd, Adrienne L Edkins, et al. Stress biology: Complexity and multifariousness in health and disease. Cell stress & chaperones. 2024. 29. 1. 143-157
  • Takanori Eguchi. Exosome. Journal of Okayama Medical Association. 2024. 136. 1. 33-36
  • Kunihiro Yoshida, Kaung Htike, Takanori Eguchi, Hotaka Kawai, Htoo Shwe Eain, Manh Tien Tran, Chiharu Sogawa, Koki Umemori, Tatsuo Ogawa, Hideka Kanemoto, et al. Rab11 suppresses head and neck carcinoma by regulating EGFR and EpCAM exosome secretion. Journal of oral biosciences. 2023. 66. 1. 205-216
  • Koki Umemori, Kisho Ono, Takanori Eguchi, Hotaka Kawai, Tomoya Nakamura, Tatsuo Ogawa, Kunihiro Yoshida, Hideka Kanemoto, Kohei Sato, Kyoichi Obata, et al. EpEX, the soluble extracellular domain of EpCAM, resists cetuximab treatment of EGFR-high head and neck squamous cell carcinoma. Oral oncology. 2023. 142. 106433-106433
  • Mona Sheta, Kunihiro Yoshida, Hideka Kanemoto, Stuart K Calderwood, Takanori Eguchi. Stress-Inducible SCAND Factors Suppress the Stress Response and Are Biomarkers for Enhanced Prognosis in Cancers. International journal of molecular sciences. 2023. 24. 6
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MISC (121)：
  • 奥舎 有加, 江口 傑徳, Tran Manh T., 十川 千春, 吉田 賀弥, 板垣 まみ, Taha Eman A., 小野 喜章, 青山 絵理子, 岡村 裕彦, et al. 高転移性癌細胞由来の細胞外小胞に搭載されたMMP3によるCtgf/Ccn2発現調節機能と癌転移促進(Extracellular vesicles enriched with moonlighting metalloproteinase are highly transmissive, Pro-tumorigenic, and trans-activates cellular communication network factor(CCN2/CTGF): CRISPR against cancer). Journal of Oral Biosciences Supplement. 2022. 2022. 35-35
  • 奥舎 有加, タハ・エマン, 陸 彦因, シータ・モナ, 河合 穂高, 十川 千春, 岡元 邦彰, 江口 傑徳. 細胞外小胞に搭載されたムーンライティングMMPによるマトリックス制御と転移促進(Metalloproteinase on extracellular vesicles regulates ECM in tumor microenvironment and promotes invasion and metastasis). 日本癌学会総会記事. 2022. 81回. P-1118
  • 江口 傑徳, ラング・ベンジャミン, シータ・モナ, チャン・マン, ヴェンギェル・バーバラ, カルダーウッド・スチュアート. 転写因子MZF1とSCAND1による相反的なEMT制御(MZF1 and SCAND1 reciprocally regulate epithelial-to-mesenchymal transition). 日本癌学会総会記事. 2022. 81回. E-3046
  • 河合 穂高, メイ・ワトウ, 高畠 清文, 冨田 秀太, 小野 喜章, 江口 傑徳, 大原 利章, 中野 敬介, 長塚 仁. 口腔癌間質由来のCCL2はCCR2陽性骨髄由来免疫抑制細胞の腫瘍間質への動員に関与する. 日本がん免疫学会総会プログラム・抄録集. 2022. 26回. 91-91
  • 森 彩乃, 山本 直史, 井手口 英隆, 河村 麻理, 河本 美奈, 伊東 昌洋, 小野 喜章, 中山 真彰, 江口 傑徳, 大野 充昭, et al. 侵襲性歯周炎の血液診断マーカー候補となる細胞外小胞由来マイクロRNAとその炎症誘導機構の探索. 日本歯周病学会会誌. 2022. 64. 春季特別. 114-114
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Books (21)：
  • Multiplex immunostaining method to distinguish HSP isoforms. In: Methods Molecular Biology, Vol. , Stuart K. Calderwood and Thomas L. Prince (Eds): Chaperones.
    Springer Nature Switzerland AG, Cham, Switzerland. 2023
  • Multiple targeting of HSP isoforms to challenge isoform specificity and compensatory expression. In: Methods Molecular Biology, Vol. , Stuart K. Calderwood and Thomas L. Prince (Eds): Chaperones.
    Springer Nature Switzerland AG, Cham, Switzerland. 2023
  • Proteomic profiling of the extracellular vesicle-chaperome in cancer. In: Methods Molecular Biology, Vol. , Stuart K. Calderwood and Thomas L. Prince (Eds): Chaperones.
    Springer Nature Switzerland AG, Cham, Switzerland. 2023
  • Large-scale databases and portals on cancer genome to analyze chaperone genes correlated to patient prognosis. In: Methods Molecular Biology, Vol. , Stuart K. Calderwood and Thomas L. Prince (Eds): Chaperones.
    Springer Nature Switzerland AG, Cham, Switzerland. 2023
  • Monitoring of the heat shock response with a real-time luciferase reporter. In: Methods Molecular Biology, Stuart K. Calderwood and Thomas L. Prince (Eds): Chaperones
    Springer Nature Switzerland AG, Cham, Switzerland. 2023
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Lectures and oral presentations  (83)：
  • Extracellular Vesicles as a Drug Carrier for Targeting Cancer Metabolism Kinase
    (Biomedical Society for Stress Response Japan, the 17th Annual Meeting. 2023)
  • Discovery and targeting of metabolism kinase in cancer organoid EV
    (The 10th JSEV Annual Meeting 2023)
  • Learn from the oldoncology, know the new: RNA-seq analysis of human chondrosarcoma-derived cells. Frontiers in CCN family reseaerch
    (Japan CCN Family Study Group 2023)
  • Extracellular Vesicle Kinases Secreted by Metastatic Cancer Organoids
    (The 82nd Annual Meeting of the Japanese Cancer Association, English Oral Session 2023)
  • Extracellular Vesicles (EVs) as a Drug Carrier for Targeting Cancer Metabolism Kinase
    (Brainstorming-2023 2023)
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Education (3)：
  • 1999 - 2003 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences
  • 1993 - 1999 Okayama University Dental School
  • 1990 - 1993 広島大学附属福山高校
Professional career (1)：
  • PhD, DDS
Work history (7)：
  • 2021/11 - 2024/03 Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Associate Professor
  • 2016/04 - 2021/10 Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
  • 2011/09 - 2015/12 Harvard Medical School Instructor
  • 2011/07 - 2011/08 Harvard Medical School Research fellow
  • 2009/01 - 2011/06 National Center for Geriatrics and Gerontrogy Section Chief
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Committee career (12)：
  • 2022 - 現在 日本臨床ストレス応答学会 広報
  • 2022 - 現在 日本臨床ストレス応答学会 若手奨励賞審査委員
  • 2021/04 - 現在 岡山大学歯学部 公募問題(CBT)作成部会委員
  • 2021/03 - 現在 岡山大学歯学部 国家試験対策委員
  • 2020/04 - 現在 日本臨床ストレス応答学会 幹事
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Awards (6)：
  • 2020/11 - 岡山歯学会優秀論文賞
  • 2018/09 - Braingstorming2018 Best Presentation Award
  • 2016/10 - 両備檉園記念財団 生物学研究奨励賞
  • 2009 - 岡山歯学会奨励論文賞
  • 2009 - Japanese Society of Cartilage Metabolism Award
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Association Membership(s) (18)：
Japanese Society for Extracellular Vesicles (JSEV) ,  BioMedical Society of Stress Response (BSSR) Japan ,  THE JAPANESE CANCER ASSOCIATION ,  歯科基礎医学会 ,  Okayama Dental Society ,  International Society for Extracellular Vesicles (ISEV) ,  THE JAPANESE PHARMACOLOGICAL SOCIETY ,  The Molecular Biology Society of Japan ,  American Society for Biochemistry and Molecular Biology ,  Japanese Society of Cartilage Metabolism ,  Japanese Biochemical Society ,  アメリカ骨代謝学会 ,  The Japanese Society for Bone and Mineral Research ,  日本補綴歯科学会 ,  日本歯周病学会 ,  エピジェネティクス研究会 ,  日本CCN研究会 ,  International CCN Society
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