Rchr
J-GLOBAL ID:200901056456322224
Update date: Oct. 09, 2024
Miyasaka Tomohiro
ミヤサカ トモヒロ | Miyasaka Tomohiro
Affiliation and department:
Job title:
Professor
Research field (3):
Neuroscience - general
, Neuropathology
, Neuroanatomy and physiology
Research keywords (12):
Neurofibrillary tangels
, Neurodegenerative disease
, dementia
, model mouse
, 線虫
, タウ
, 神経細胞死
, アルツハイマー病
, C. elegans
, tau
, neuronal cell death
, Alzheimer's disease
Research theme for competitive and other funds (15):
- 2024 - 2028 Optical control of auditory pathway for next generation auditory prosthesis
- 2022 - 2026 微小管結合タンパク質の機能損失が個体間コミュニケーションに与える影響
- 2021 - 2025 近赤外レーザーを用いた次世代人工内耳の開発と評価
- 2017 - 2020 Development of novel therapeutic agents for Alzheimer's disease based on analysis of neuroprotective signals and regulation of tau phosphorylation
- 2014 - 2019 Mechanism of tau protein aging and neurodegeneration
- 2010 - 2011 Development of anti-tauopathy drugs using C. elegans.
- 2008 - 2009 Imbalanced expression of tau and tubulin is an essential step for pathogenesis of tauopathy.
- 2006 - 2007 線虫モデルを用いたタウオパチー神経変性機構の解明と治療法の探索
- 2005 - 2005 変異型タウ遺伝子導入によるヒト痴呆疾患モデルマウスの作製と解析
- 2004 - 2005 線虫モデルを用いたタウオパチー神経変性機構の解明
- 2001 - 2004 Mechanism of NFT formation
- 2000 - 2004 Hyperphosphorylation and aggregation of tau protein, and neuronal death
- 2002 - 2003 アルツハイマー病脳における異常タウと神経細胞死の解明
- タウオパチー神経変性メカニズムの解明
- Study of the mechanisms of neuronal cell death in tauopathy brains.
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Papers (61):
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Haruko Miyazaki, Saki Nishioka, Tomoyuki Yamanaka, Manabu Abe, Yukio Imamura, Tomohiro Miyasaka, Nobuto Kakuda, Toshitaka Oohashi, Tomomi Shimogori, Kazuhiro Yamakawa, et al. Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP. Transgenic research. 2024. 33. 3. 99-117
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Genki Kimura, Ai Tagami, Rina Fukui, Masaki Yaita, Tomohiro Miyasaka. Airway inflammation in a novel mouse model of asthma-COPD overlap induced by co-exposure to papain and tobacco smoke. Biochemical and biophysical research communications. 2024. 709. 149831-149831
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Eiichi Tokuda, Yume Sakashita, Naoya Tokoro, Ayano Date, Yasuhiro Kosuge, Tomohiro Miyasaka. MS785-MS27 Reactive Misfolded/Non-Native Zn-Deficient SOD1 Species Exhibit Cytotoxicity and Adopt Heterozygous Conformations in Motor Neurons. International Journal of Molecular Sciences. 2024. 25. 11. 5603-5603
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Hiroyuki Morino, Takashi Kurashige, Yukiko Matsuda, Maiko Ono, Naruhiko Sahara, Tomohiro Miyasaka, Yoshiyuki Soeda, Hitoshi Shimada, Yu Yamazaki, Tetsuya Takahashi, et al. Clinical and Pathological Features of FTDP-17 with MAPT p.K298_H299insQ Mutation. Movement disorders clinical practice. 2024
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Ayaka Hagita-Tatsumoto, Tomohiro Miyasaka. Quantitative Microtubule Fractionation Technique to Separate Stable Microtubules, Labile Microtubules, and Free Tubulin in Mouse Tissues. Journal of Visualized Experiments. 2023. 201
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MISC (47):
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外山友美子, 徳平壮一郎, 朴洪宣, 韮澤崇, 角田伸人, 宮坂知宏, 村山繁雄, 齊藤祐子, 内藤康秀, 貫名信行, et al. イメージング質量分析法を用いたアルツハイマー病脳の組織マルチオミクス解析. Dementia Japan. 2021. 35. 4
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宮坂知宏. Considering the abnormality of pathological tau; lessons from physiological tau!. 月刊細胞. 2021. 53. 1
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外山友美子, 朴洪宣, 梶田遼, 角田伸人, 宮坂知宏, 韮澤崇, 村山繁雄, 貫名信行, 井原康夫, 池川雅哉. イメージング質量分析法とショットガンプロテオーム解析を用いた脳病理解析. Dementia Japan. 2020. 34. 4
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宮坂知宏, 常嘉瑞, 姚シビ, 角田聡子, 建部陽嗣, 徳田隆彦. マウス腎臓における微小管結合タンパク質タウの発現. Dementia Japan. 2020. 34. 4
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萩田彩香, 角田聡子, 延原美香, 角田伸人, 宮坂知宏. In vivoにおけるタウのリン酸化と微小管結合能への影響. Dementia Japan. 2020. 34. 4
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Patents (10):
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Tau aggregation inhibitor
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リン酸化タンパク質の組織学的検出方法及びキット
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タウ凝集阻害剤
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Tau aggregation inhibitor
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2,4-ジアミノフェノール誘導体、及び、タウ及び/又はアミロイドβの凝集阻害剤
more...
Books (3):
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Molecular Neurobiology of Alzheimer Disease and Related Disorders.
Karger 2004
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Molecular Neurobiology of Alzheimer Disease and Related Disorders.
Karger 2004
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Molecular Neurobiology of Alzheimer Disease and Related Disorders.
2004
Education (6):
Professional career (2):
- 博士(医学) (北海道大学)
- 修士(薬学) (北海道大学)
Work history (2):
- 2023/04 - 現在 Nihon University Graduate School of Pharmacy Professor
- 2023/04 - 現在 Nihon University School of Pharmacy Professor
Association Membership(s) (7):
米国神経科学会
, 日本認知症学会
, 日本神経化学会
, Society for Neuroscience
, Japanese society for dementia
, Japanese society for neurochemistry
, 日本神経病理学会
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