2019 - 2022 Effect of gravity on aging and its mechanism
2019 - 2022 Lung fibrosis suppression effect by hydrogen inhalation at ARDS subacute-chronic phase: Verification by model mouse
2017 - 2022 Improvement in oxidative stress-induced low mobility of mouse sperm by H2 treatment
2018 - 2021 Elucidation of the mechanism of oxidative stress response of molecular hydrogen mediated by membrane lipids
2016 - 2019 Basic research for molecular mechanisms underlying antiinflammatory and antioxidative effects of molecular hydrogen
2015 - 2018 Real-time imaging of morphological changes in mitochondrial cristae during the aging process
2014 - 2017 The effect of hydrogen for retinal oxidative stress
2013 - 2016 Repair method of steatotic grafts aiming to resolve the organ shortage
2012 - 2015 Molecular hydrogen medicine: Possible mechanisms of hydrogen antioxidant activity
2010 - 2012 Protection by hydrogen therapy against oxidative stress induced various lung diseases.
2009 - 2011 Protection of the Retina by Rapid Diffusion of Hydrogen : Administration of Hydrogen-Loaded Eye Drops in Retinal Ischemia. Reperfusion Injury
2008 - 2010 Development toward preventive application of molecular hydrogen with a novel concept for lifestyle-related diseases
2008 - 2010 Protective effects of molecular hydrogen on a stress-induced brain dysfunction
2008 - 2010 Effect of hydrogen on prevention and improvement of diabetes
2007 - 2008 水素ガス吸引による虚血再潅流障害の軽減
2006 - 2007 発がん時におけるミトコンドリア遺伝子体細胞変異の蓄積によるがん増殖促進機構
2005 - 2007 Research for requirement of down-regulation of energy metabolism for neuronal differentiation
2005 - 2007 Inhibition of liver degeneration by protein transduction method using the super anti-cell death protein
2005 - 2006 Regulation of the survival of mature oligodendrocytes by protein transduction of p38 MAP kinase
2005 - 2005 発癌時におけるミトコンドリア遺伝子体細胞変異に蓄積による核遺伝子発現制御
2002 - 2004 Inhibition of ischemic neuronal death by the super anti-death protein and its therapeutic application for brain ischemic injury
2002 - 2004 A possible role for an anti-apoptotic protein, survivin, in survival of neurons in the brain
2000 - 2002 Aldehydes accumulated in mitochondria as risk factors to neurodegenerative diseases
2001 - 2001 糖尿病の危険因子としてのミトコンドリア遺伝子ヘテロプラズミー変異
水素分子の生体における機能解析、医学への応用.加齢に伴う神経変性疾患における酸化ストレスの影響.
Hydrogen as a therapeutic antioxidant, its molecular and cellular mechanisms
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Papers (103):
Masumi Iketani, Mai Hatomi, Yasunori Fujita, Nobuhiro Watanabe, Masafumi Ito, Hideo Kawaguchi, Ikuroh Ohsawa. Inhalation of hydrogen gas mitigates sevoflurane-induced neuronal apoptosis in the neonatal cortex and is associated with changes in protein phosphorylation. Journal of neurochemistry. 2024
Toshiyuki Aokage, Masumi Iketani, Mizuki Seya, Ying Meng, Kohei Ageta, Hiromichi Naito, Atsunori Nakao, Ikuroh Ohsawa. Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival. Experimental gerontology. 2023. 180. 112270-112270
Yasunori Fujita, Shoji Shinkai, Yu Taniguchi, Yuri Miura, Masashi Tanaka, Ikuroh Ohsawa, Akihiko Kitamura, Masafumi Ito. Association Between Serum GDF15 Concentration and Total Mortality in Community-Dwelling Japanese Older Populations: The Involvement of Renal Dysfunction. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023. 78. 9. 1701-1707
The University of Tokyo The Faculty of Engineering
Department of Chemical Engineering, Faculty of Engineering, University of Tokyo
Professional career (1):
Ph. D
Work history (9):
2010/04 - 現在 東京都健康長寿医療センター研究所 生体調節機能研究 研究副部長
2008 - :日本医科大学老人病研究所教授
2003 - :日本医科大学老人病研究所講師
2001 - :日本医科大学老人病研究所助手
2001 - : Researcher Associate, Institute of Gerontology, Nippon Med Sch
1994 - :国立精神・神経センター神経研究所 代謝研究部 ポスドク
1994 - : Researcher, National Institute of Neuroscience, NCNP,
1984 - :日本ゼオン株式会社研究員
1984 - : Researcher, Zeon Corporation
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Committee career (3):
- 現在 日本分子状水素医学生物学会 理事長
- 現在 日本基礎老化学会 監事
- 現在 日本ミトコンドリア学会 評議員
Association Membership(s) (10):
日本ミトコンドリア学会
, 日本分子生物学会
, 日本生化学会
, 日本神経化学会
, 化学工学会
, The Society of Chemical Engineers, Japan
, The Japanese Society of Neurochemistry
, The Japanese Biochemical Society
, 日本分子状水素医学生物学会
, 日本基礎老化学会