Matsushita Osamu

2018 - 2021 Elucidation of substrate recognition mechanism of bacterial collagenases to develop angiogenic drug seeds

2018 - 2021 Development of a novel biomimetic vascular graft using original collagen anchoring domain with growth factor

2018 - 2021 Delivery of Stem cell/growth factor using in situ-formed hydrogels for fracture repair

2017 - 2020 Development of functional multilayered mesenchymal stem cells sheet for lumbar fusion surgery

2014 - 2017 Musculoskeletal regeneration using Growth factor-anchored materials

2014 - 2017 Clarification of molecular mechanisms underlying the analgesic effect of botulinum toxin and applied study

2014 - 2017 Structure-function analysis of bacterial toxins in tissue destruction to apply their functional domains to regenerative medicine

2014 - 2017 Establishment of novel osteochondral allografting combined with growth factor- collagen-binding domain fusion technology

2014 - 2017 Development of collagen binding VEGF-C for lymphangiogenesis

2013 - 2015 Development of novel fracture healing methods using artificical perioteum and collagen-binding growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase

2011 - 2013 Preclinical study to elucidate molecular mechanism of matrix anchoring using bacterial proteins

2010 - 2012 Generating artificial parenchymal and hollow organs fabricated with collagen fibrils,various cells, and cytokines using a bioreactor that we have developed

2009 - 2011 Basic science technology study of new revision total hip arthroplasty using a fusion protein and the nanowire processing

2008 - 2010 Translational research on a drug delivery system using substrate binding domain derived from bacterial collagenases

2006 - 2007 A study on a mechanism for the transcriptional regulation of an epsilon-toxin gene by a novel type of bent DNA

2006 - 2007 Interdisciplinary study on the calcium-dependent conformational change of collagen-binding domain from clostridial collagenases

2004 - 2005 A study on the molecular mechanism of substrate recognition by Clostridial collagenases

2003 - 2004 A study on the mechanism underlying the action of Clostridium perfringens alpha- and epsilon-toxins to membrane lipid rafts

2003 - 2004 Studies on the law temperature-dependent enhancement of transcription by a bent DNA

2002 - 2003 Basic research on the development of novel vaccines with collagen-anchoring potency.

2002 - 2003 特殊ベント・プロモーターを利用した新規高発現ベクターの構築

2001 - 2002 Study on structure biology and molecular pathology of Clostridium perfringens epsilon-toxin

2000 - 2001 Drug design based on the three-dimensional structure of collagen-binding domain, and its application

2000 - 2001 水素ガス産生用ウエルシュ菌バイオリアクター開発のための基礎研究

1999 - 2000 Studies on neurotropism of Clostridium perfringens epsilon-toxin and molecular mechanism of its toxicity toward neuronal cells

1999 - 2000 Neuron specific calcium-binding Protein, calbrain, is involved in memory formation.

1998 - 1999 Function of promoter upstream bent DNA of the Clostridium perfringens phospholipase C gene

1997 - 1999 Analysis of the activation and mode of action of Clostridium perfringens ε-toxin

1997 - 1998 コラーゲン結合ドメインによるガス壊疸の発症予防

1996 - 1997 Study on function of phospholipase C gene binding protein from Clostridium perfringens

1996 - 1996 ウェルシュ菌MSCLチャンネルによる病原遺伝子発現制御に関する研究

1994 - 1994 ガス壊疽菌プロテアーゼのプロ領域ペプチドの機能解析

1993 - 1994 Function of protein (s) which can bind to an alpha-toxin gene of Clostridium perfringens

1993 - 1993 ガス壊疽菌コラゲナーゼの反応機構の解析

1991 - 1991 分子生物学的手法による酸耐性セルロース分解菌の作成と,反芻獣肥育事故防止への応用

1990 - 1991 Developmental Studies on the Laboratory diagnosis at an early stage of Mycoplasam pneumoniae-infection (mycoplasmal pneumonia)

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