Research theme for competitive and other funds (17):
2023 - 2026 アセチルコリン/ドパミン神経回路を標的としたうつ病の新規治療法の探索
2023 - 2026 抗うつ薬作用増強に必要なドパミン・ノルアドレナリン神経回路機構の解明
2023 - 2026 Development of treatments for post traumatic stress disorder related to surgery and intensive care.
2022 - 2025 炎症性疾患によるうつ病発症機序の解明:脳内ドパミンシグナルに着目して
2022 - 2025 Development of novel therapeutics for neuropsychiatric disorders targeting dopamine signaling
2019 - 2022 Involvement of dopamine and noradrenaline signaling mechanisms in depression and schizophrenia.
2019 - 2022 Pharmacological treatment of depression: development of novel therapeutics targeting the dopamine neuronal system
2017 - 2020 Melatonin signaling pathway as a novel target for the treatment for sepsis-associated encephalopathy
2016 - 2020 Development of therapeutic method to suppress drug abuse by suppressing dopamine D1 signal
2018 - 2020 海馬ドパミン・ノルアドレナリン入力バランス制御によるうつ病治療戦略の確立
2016 - 2019 Development of novel therapeutic approaches focused on phosphodiesterases for psychiatric disorders
2016 - 2019 Investigation of dopamine neurocircuits to identify novel therapeutic targets in psychiatric disorders
2014 - 2017 Role of chondroitin sulfate-E in the modulation of neuronal morphology
2011 - 2012 ドーパミンD1受容体シグナルに着目した薬物依存および統合失調症の治療法開発
2009 - 2010 薬物依存症の治療法開発:逆耐性を消失させるドーパミンD1 受容体シグナル
2009 - 2010 薬物依存症の治療法開発:逆耐性を消失させるドーパミンD1受容体シグナル
2006 - 2007 Map of dopamine signaling in the neostriatum under normal and pathophysiological conditions
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Papers (29):
Ryusuke Sin, Naoki Sotogaku, Yoshinori N. Ohnishi, Takahide Shuto, Mahomi Kuroiwa, Yukie Kawahara, Keita Sugiyama, Yuki Murakami, Masaaki Kanai, Hiroshi Funakoshi, et al. Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments. Brain, Behavior, and Immunity. 2023
Mahomi Kuroiwa, Takahide Shuto, Taku Nagai, Mutsuki Amano, Kozo Kaibuchi, Angus C Nairn, Akinori Nishi. DARPP-32/protein phosphatase 1 regulates Rasgrp2 as a novel component of dopamine D1 receptor signaling in striatum. Neurochemistry international. 2023. 162. 105438-105438
Keita Sugiyama, Mahomi Kuroiwa, Takahide Shuto, Yoshinori N Ohnishi, Yukie Kawahara, Yuta Miyamoto, Takaichi Fukuda, Akinori Nishi. Subregion-Specific Regulation of Dopamine D1 Receptor Signaling in the Striatum: Implication for L-DOPA-Induced Dyskinesia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021. 41. 30. 6388-6414