Onishi Yoshiaki

オオニシヨシアキ | Onishi Yoshiaki

Affiliation and department：
Job title： Director-General
Homepage URL (1)： http://www.aist.go.jp/RESEARCHERDB/cgi-bin/worker_detail.cgi?call=namae&rw_id=Y36431210

Research field (1)： Molecular biology

Research theme for competitive and other funds (12)：

2014 - 2017 Establishment of physiological time measurement using saliva
2011 - 2013 Isolation of thecandidate gene for the marker of the body time determinant in human saliva.
2006 - 2008 Analysis of the clock mechanism in salivary gland cells
1997 - 1998 唾液腺アポトーシスにおけるhnRNPAIの機能解析
1996 - 1997 Regulation of biodefense system by neutrophil apoptosis

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Papers (18)：

Tatsunosuke Tomita, Renu Wadhwa, Yoshiaki Onishi. Natural Compounds that Modulate Circadian Rhythms. Current topics in medicinal chemistry. 2024
Tatsunosuke Tomita, Yoshiaki Onishi. Epigenetic Modulation of Circadian Rhythms: Bmal1 Gene Regulation. Chromatin and Epigenetics. 2020
Tatsunosuke Tomita, Ryoji Kurita, Yoshiaki Onishi. Epigenetic regulation of the circadian clock: role of 5-aza-2 '-deoxycytidine. BIOSCIENCE REPORTS. 2017. 37. 3
Yoshikatsu Ogawa, Yasuhiro Kawano, Yoshimitsu Yamazaki, Yoshiaki Onishi. Shikonin shortens the circadian period: Possible involvement of Top2 inhibition. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014. 443. 1. 339-343
Yoshiaki Onishi, Yasuhiro Kawano. Rhythmic binding of Topoisomerase I impacts on the transcription of Bmal1 and circadian period. NUCLEIC ACIDS RESEARCH. 2012. 40. 19. 9482-9492

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MISC (90)：

Tatsunosuke Tomita, Renu Wadhwa, Sunil C. Kaul, Ryoji Kurita, Naoshi Kojima, Yoshiaki Onishi. Withanolide Derivative 2,3-Dihydro-3β-methoxy Withaferin-A Modulates the Circadian Clock via Interaction with RAR-Related Orphan Receptor α (RORa). Journal of Natural Products. 2021. 84. 7. 1882-1888
Tatsunosuke Tomita, Taisuke Mori, Yoshiaki Onishi. β-Arrestin 1 (ARRB1) serves as a molecular marker of the peripheral circadian rhythm. International journal of oral science. 2019. 11. 4. 32-32
冨田辰之介, 栗田僚二, 大西芳秋. 時計遺伝子BMAL1のメチル化による転写抑制. 日本分子生物学会年会プログラム・要旨集(Web). 2016. 39th
冨田辰之介, 宮崎歴, 大西芳秋, 本田真也, 石田直理雄, 大石勝隆. 時計分子PER2-CRY1の相互作用に必要なPER2C末端領域の機能解析. 日本薬学会年会要旨集. 2010. 130年会. 3. 208-208
M Kato, Y Onishi, Y Wada-Kiyama, R Kiyama. Biochemical screening of stable dinucleosomes using DNA fragments from a dinucleosome DNA library. JOURNAL OF MOLECULAR BIOLOGY. 2005. 350. 2. 215-227

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Patents (14)：

生体リズムマーカー
概日リズム調整剤
時計遺伝子のDNAメチル化による概日リズム制御機構のレポーターアッセイ系
生体リズムの制御剤
生体リズムの制御剤

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Education (4)：

Hiroshima University Faculty of Dentistry
Hiroshima University Graduate School of Dental Science
Hiroshima University School Dentistry
Hiroshima University Graduate School of Dentistry

Professional career (1)：

Ph.D.

Work history (20)：

2022/04 - 現在 National Institute of Advanced Industrial Science and Technology AIST Shikoku Director - General
2019/04 - 2022/03 National Institute of Adnanced Industrial Science and Technology Biomedical Research Institute Director
2016/04 - 2019/03 AIST Research Associate
2015/04 - 2016/03 産業技術総合研究所生命工学領域研究戦略部研究企画室長
2014/04 - 2015/03 産業技術総合研究所ライフサイエンス分野研究企画室研究企画室長

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Association Membership(s) (6)：

American Society for Biochemistry and Molecular Biology , 日本分子生物学会 , 日本生化学会 , The Molecular Biology Society of Japan , The Japanese Cancer Association , The Japanese Biochemical Society

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