Tainaka Kazuki

タイナカカズキ | Tainaka Kazuki

Affiliation and department：
Job title： Assistant Professor

Research field (2)： Biochemistry , Neuroanatomy and physiology

Research keywords (6)：イメージング , ケミカルバイオロジー , 神経病理学 , 組織透明化 , Photochemistry , Bioorganic Chemistry

Research theme for competitive and other funds (34)：

2023 - 2026 ひとてんかん原性病態機序を知りこれを制御する
2022 - 2026 Development of neuroregeneration therapy mediated by peripheral blood mononuclear cell-derived exosomes through cell modification.
2022 - 2026 炎症シグナルによる皮質神経回路形成の攪乱とリモデリング
2022 - 2025 Whole human brain pathological analysis by 3D imaging with single cell resolution
2021 - 2025 Research on the role of tissue-resident NK cells in cancer immune-surveillance

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Papers (72)：

Shoji Saito, Yuka Nakamura, Satoshi Miyashita, Tokiharu Sato, Kana Hoshina, Masayasu Okada, Hitoshi Hasegawa, Makoto Oishi, Yukihiko Fujii, Jakob Körbelin, et al. CRISPR/CasRx suppresses KRAS-induced brain arteriovenous malformation developed in postnatal brain endothelial cells in mice. JCI Insight. 2024. 9. 22
Shoji Saito, Yuka Nakamura, Satoshi Miyashita, Tokiharu Sato, Kana Hoshina, Masayasu Okada, Hitoshi Hasegawa, Makoto Oishi, Yukihiko Fujii, Jakob Körbelin, et al. CRISPR/CasRx suppresses KRAS-induced brain arteriovenous malformation developed in postnatal brain endothelial cells in mice. JCI insight. 2024. 9. 22
Fayrouz Naim, Rie Hasebe, Shintaro Hojyo, Yukatsu Shichibu, Asuka Ishii, Yuki Tanaka, Kazuki Tainaka, Shimpei I Kubota, Katsuaki Konishi, Masaaki Murakami. In situ Microinflammation Detection Using Gold Nanoclusters and a Tissue-clearing Method. Bio-protocol. 2023. 13. 7. e4644
Yuka Nakamura, Miyuki Kurabe, Mami Matsumoto, Tokiharu Sato, Satoshi Miyashita, Kana Hoshina, Yoshinori Kamiya, Kazuki Tainaka, Hitoshi Matsuzawa, Nobuhiko Ohno, et al. Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord. eLife. 2023. 12
Kazuhisa Funayama, Kazuki Tainaka, Akihide Koyama, Rieka Katsuragi-Go, Natsumi Nishikawa-Harada, Ryoko Higuchi, Takashi Aoyama, Hiraku Watanabe, Naoya Takahashi, Hisakazu Takatsuka. Detection and Morphological Analysis of Micro-Ruptured Cortical Arteries in Subdural Hematoma: Three-Dimensional Visualization Using the Tissue-Clearing Clear, Unobstructed, Brain/Body Imaging Cocktails and Computational Analysis Method. Diagnostics (Basel, Switzerland). 2022. 12. 11

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MISC (27)：

久保田晋平, 高橋恵生, 田井中一貴, 江幡正悟, 上田泰己, 宮園浩平. Whole-organ pathological profiling with single-cell resolution. 日本病理学会会誌. 2021. 110. 1
Kubota Shimpei I., Takahashi Kei, Nishida Jun, Ehata Shogo, Tainaka Kazuki, Ueda Hiroki R., Miyazono Kohei. Whole-organ profiling of cancer metastasis by tissue clearing and light-sheet fluorescent microscopy. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2020. 93. 0. 1-YIA-16
久保田晋平, 高橋恵生, 西田純, 江幡正悟, 田井中一貴, 上田泰己, 宮園浩平. CUBIC-癌分析法を用いた癌転移の全身/全組織的特性解析(Whole-body/organ profiling of cancer metastasis with CUBIC-Cancer analysis). 生命科学系学会合同年次大会. 2017. 2017年度. [2P-1450]
久保田晋平, 高橋恵生, 西田純, 江幡正悟, 田井中一貴, 上田泰己, 宮園浩平. CUBIC-癌分析法を用いた癌転移の全身/全組織的特性解析(Whole-body/organ profiling of cancer metastasis with CUBIC-Cancer analysis). 生命科学系学会合同年次大会. 2017. 2017年度. [2P-1450]
Qianhui Zhang, Hiroko Yukinaga, Dimitri Perrin, Kazuki Tainaka, Hiroki R. Ueda. Pharmacological analysis of sleep consolidation mechanisms in mammals. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2016. 130. 3. S140-S140

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Patents (10)：

光透過性に優れた生物材料を調製するための組成物およびその利用(国内出願)
非天然型塩基を含むオリゴデオキシヌクレオチドの切断による5’末端リン酸化オリゴデオキシヌクレオチドの製造方法(PCT出願)
光透過性に優れた生物材料を調製するための組成物およびその利用(国内出願)
非天然型塩基を含むオリゴデオキシヌクレオチドの切断による5’末端リン酸化オリゴデオキシヌクレオチドの製造方法(国内出願)
メチルシトシンの簡便検出法(PCT出願)

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Lectures and oral presentations (18)：

CUBIC: Whole-organ, whole-body imaging with single-cell resolution using chemical cocktails
(2019)
組織透明化による3D神経病理学
(第16回日本病理学会カンファレンス 2019)
Comprehensive 3D Imaging by Tissue Clearing Technique CUBIC
(Neuro2019 2019)
3D神経病理学に向けたホールマウント染色手法の開発
(第60回日本神経病理学会総会学術研究会 2019)
CUBIC: 組織透明化技術による3Dイメージング
(第60回新潟生化学懇話会 2019)

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Education (2)：

2001 - 2006 Kyoto University
1997 - 2001 Kyoto University Faculty of Engineering School of Industrial Chemistry

Professional career (1)：

博士(工学) (京都大学)

Work history (10)：

2021/06 - 現在 Niigata University Brain Research Institute Professor
2018/10 - 2021/05 Niigata University Brain Research Institute Tenure-track Professor
2017/01 - 2018/09 Niigata University Brain Research Institute Specially Appointed Professor
2013/04 - 2016/12 The University of Tokyo
2010/10 - 2013/03 理化学研究所生命システム研究センター研究員

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Awards (4)：

2017/06 - 第58回日本神経病理学会総会学術研究会優秀ポスター賞
2015/07 - Anne Heidenthal Prize for Fluorescence Research at International Conference on Systems Biology of Human Disease 2015
2008/03 - 日本化学会第88春季年会優秀講演賞
2004/03 - 日本化学会第84春季年会学生講演賞

Association Membership(s) (5)：

THE JAPANESE PHARMACOLOGICAL SOCIETY , THE JAPANESE PHOTOCHEMISTRY ASSOCIATION , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , THE JAPANESE SOCIETY OF NEUROPATHOLOGY , THE CHEMICAL SOCIETY OF JAPAN

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