Higuchi Kazuhiro

ヒグチカズヒロ | Higuchi Kazuhiro

Affiliation and department：
Homepage URL (1)： https://u-lab.my-pharm.ac.jp/~knbskg/index.html

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (3)： oxidation of indole , sulfonium salt , Synthesis of natural compound

Research theme for competitive and other funds (5)：

2022 - 2027 Study of the use of sulfur (IV) atom: Synthesis and reaction of alkylsulfonium salts
2016 - 2019 チオニウムを用いたアリールカップリング反応の開発と縮合型複素環骨格への展開
2009 - 2011 Synthesis and Utilities of 2, 2-Disubstituted Indolin-3-one Using of Mannich-type Reaction
2007 - 2009 Synthetic Study of Low Molecular Peptide Mimetics toward Platelet Aggregation Inhibitors
2002 - 2004 ピロロカルバゾール構造を鍵シントンとするインドールアルカロイドの合成研究

Papers (53)：

Motoki Ito, Ryuhei Oda, Akari Shoji, Kazuhiro Higuchi, Shigeo Sugiyama. Functionalization of Siloxanes with Arynes Generated from o-Triazenylarylboronic Acids. Chemical and Pharmaceutical Bulletin. 2024. 72. 5. 487-497
Kazuhiro Higuchi, Kai Yamamoto, Shunsuke Nakamura, Haruka Naruse, Motoki Ito, Shigeo Sugiyama. Preparation of Alkyl Di(p-tolyl)sulfonium Salts and Their Application in Metal-Free C(sp3)-C(sp3) and C(sp3)-C(sp2) Bond Formations. Organic Letters. 2023. 25. 20. 3766-3771
Motoki Ito, Yuka Yamabayashi, Yuta Takishima, Kazuhiro Higuchi, Shigeo Sugiyama. Aryne Generation from o-Triazenylarylboronic Acids Induced by Brønsted Acid. Chemical and Pharmaceutical Bulletin. 2022. 70. 8. 566-572
Motoki Ito, Shigeo Sugiyama, Yui Hasegawa, Satomi Saito, Asami Onda, Kazuhiro Higuchi. Dirhodium(II)-Catalyzed Synthesis of N-(Arylsulfonyl)hydrazines by N-H Amination of Aliphatic Amines. Synlett. 2022. 33. 04. 367-370
Kazuhiro HIGUCHI, Kazunori Matsumura, Takafumi Arai, Motoki Ito, Shigeo Sugiyama. Intramolecular Aminolactonization for Synthesis of Furoindolin-2-One. Molecules. 2021. 27. 1. 102-102

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MISC (2)：

Masanori Tayu, Kazuhiro Higuchi, Tomomi Kawasaki. Functionalizations of indoles by intermolecular interrupted pummerer reaction. Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 2018. 76. 7. 678-689
樋口裕哉, 植沢芳広, 菅裕亮, 加賀谷肇, 品田昌司, 樋口和宏, 川崎知己, 田中博之, 佐藤光利. 新規フェンセリン誘導体を用いたアセチルおよびブチリルコリンエステラーゼ選択的阻害活性の構造活性相関解析(1). 臨床薬理. 2012. 43. Suppl. S283-S283

Patents (2)：

ベンジル誘導体の製造方法
Preparation of Intermediates for Novel Antitumor Spiro Compounds, Fredericamycin A and its analogs.

Lectures and oral presentations (11)：

Sulfonium salts mediated carbon-carbon bond formations via umpolung strategy
(2024)
スルホニウム塩が拓く機能性分子創製へのアプローチ
(第67回日本薬学会関東支部大会化学系シンポジウム創薬化学の深化と多様化 2023)
活性チオニウム種やマンニッヒ型反応を用いたインドールアルカロイドの合成研究
(立命館大学総合科学技術研究機構創薬科学研究センター主催創薬基盤化学研究若手セミナー第16回特別講演会 2018)
Sulfonium Species Mediated Coupling Reaction of Phenol Derivatives
(FJS-2016 2016)
Total Synthesis of (-)-Leuconoxine Featuring Mannich-type Intramolecular Cyclization and Chiral Phosphoric Acid-Catalyzed Desymmetrization
(ISHC2015 25th Congress 2015)

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Education (2)：

- 2001 Osaka University
- 1996 Meiji Pharmaceutical University Faculty of Pharmacy Department of Medicinal Chemistry

Professional career (1)：

Work history (7)：

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Committee career (1)：

Association Membership(s) (2)：

THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN , 日本薬学会

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