Otsu Makoto

2015 - 2018 Development and its applications of a versatile system for single cell array, imaging analysis and selective cell collection

2014 - 2018 The possibility that suppression of NETosis contributes to improvement of SLE

2015 - 2017 Elucidation of fibrous dysplasia pathogenesis using disease-specific iPS cells and application to drug discovery

2014 - 2017 iPS細胞由来造血幹細胞を用いた動物細胞非依存的な小児血液腫瘍疾患の治療法の開発

2015 - 2016 Investigation of pathogenesis of leukemia in Down syndrome patients using human ES and iPS cells

2015 - 2016 Immune suppressive function of allogeneic hematopoietic stem cells

2014 - 2015 Analysis of occurrence of leukemia from congenital bone marrow failure syndrome and establishment of its treatment using human iPS cells

2013 - 2014 Molecular analysis of fetal hematopoiesis using culture system with ES cells

2013 - 2014 Development and establishment of the treatment of complications in Down syndrome patients using human ES and iPS cells

2012 - 2014 A new method to sub-fractionate hematopoietic stem cells based on signal response characteristics

2012 - 2012 Investigation into the molecular mechanisms for the occurrence of leukemia using iPS cells derived from congenital bone marrow failure syndrome and establishment of the methods to prevent its occurrence

2010 - 2012 Human gene therapy model by induction of stable bone marrow chimerim with regulation of proliferative ability of hematopoietic stem cell

2011 - 2011 Analysis of human fetal hematopoiesis using human ES cells

2009 - 2011 In vivo Regulation of the Cell Fates Utilizing a Novel Inducible System of Protein Expression

2009 - 2011 Elucidation of the mechanisms underlying maintenance of hematopoietic stem cell hibernation

2007 - 2008 Identification of niche signal prescribing hibernation of hematopoietic stem cell

2005 - 2006 マルチカラーレトロウイルスベクターを用いた個体形成時の複数遺伝子競合的機能解析法

2004 - 2005 Basic Research of hematopoietic stem cell transplantation utilizing CXCR4 gene transfer

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