Research theme for competitive and other funds (17):
2024 - 2030 老化研究支援・推進に関する研究開発(生物情報・スクリーニング支援)
2022 - 2025 Elucidation of multilayered cellular responses to osmotic environment and functions of the response in macrophages
2022 - 2024 Development of genetically modified mice (Osmonitoring mice) that monitor osmotic environment in the body for an understanding of immune regulation
2017 - 2022 Analysis of sorting zones involved in protein quality control in the endoplasmic reticulum
2018 - 2021 Elucidation of osmo-physiology through analysis where and how osmotic circumstance functions in the body
2015 - 2018 Analysis of sensing and responding mechanisms for osmotic stress in mammalian cells
2013 - 2018 Homeostasis Regulation via Stress Signaling and its Molecular Basis for Drug Development
2016 - 2018 Analysis of sensing and responding mechanisms for osmotic stress in mammalian cells(Fostering Joint International Research)
2015 - 2017 The regulatory mechanisms of tumor metastasis via ASK family proteins
2013 - 2015 A genome-wide RNAi screening for clarifying the molecular mechanism of osmotic stress response in the mammalian cell
2008 - 2013 Drug development by the molecular mechanism-based analysis of stress signaling
2011 - 2012 The analysis of cellular osmotic stress sensing and response by focusing onASK3
2008 - 2009 The analysis of cellular osmotic stress response focusing on a novel kinase ASK3
Hiroki Ryuno, Yusuke Hanafusa, Takao Fujisawa, Motoyuki Ogawa, Hiroki Adachi, Isao Naguro, Hidenori Ichijo. HES1 potentiates high salt stress response as an enhancer of NFAT5-DNA binding. Communications biology. 2024. 7. 1. 1290-1290
Yizhe Zhang, Isao Naguro, Hiroki Ryuno, Amy E Herr. ContactBlot: Microfluidic Control and Measurement of the Cell-Cell Contact State to Assess Contact-Inhibited ERK Signaling. Analytical chemistry. 2024. 96. 38. 15330-7
Shoko Ito, Keisuke Kuromiya, Miho Sekai, Hiroaki Sako, Kazuhito Sai, Riho Morikawa, Yohei Mukai, Yoko Ida, Moe Anzai, Susumu Ishikawa, et al. Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 43. e2307118120