Rchr
J-GLOBAL ID：200901058006212901
Update date: Sep. 27, 2024
Nishimura Shin-Ichiro
ニシムラ シンイチロウ | Nishimura Shin-Ichiro
Affiliation and department：
Job title：
Professor
Other affiliations (1)：
Homepage URL (1)：
http://altair.sci.hokudai.ac.jp/g4/index.html
Research field (8)：
Chemical biology
, Molecular biochemistry
, Structural/physical organic chemistry
, Nanobioscience
, Genomics
, Structural biochemistry
, Bioorganic chemistry
, Applied biochemistry
Research keywords (10)：
Glycomedicine
, Glycoconjugate
, antibody
, cancer specific epitope
, organic chemistry
, epitope
, Medicinal chemistry
, Chemical Biology
, Glycotechnology
, Bio-organic chemistry
Research theme for competitive and other funds (34)：
- 2021 - 2025 進化型MBRによる下水からの有機物回収:下水道の創エネルギーインフラへの転換
- 2021 - 2024 Comprehensive glycan analysis based on resected specimens of hepatocellular carcinoma
- 2019 - 2023 Antibodies targeting dynamic epitopes generated by posttranslational protein glycosylation
- 2018 - 2021 Fundamental control of membrane fouling based on detailed information on biopolymers in surface water
- 2018 - 2020 Global identification of glycosylation form related to pain due to intervertebral degeneration
- 2016 - 2020 Analysis of alteration of N-glycan and invasiveness in hepatocellular carcinoma cell-lines
- 2016 - 2018 Analysis of N-glycans on vascular endothelial growth factor receptor-2 in diabetic retinopathy
- 2015 - 2018 Control of membrane fouling by specific removal of polysaccharides using glycoblotting
- 2013 - 2018 Exploration of Novel Markers on Cancer and Development of a Technology for the Diagnosis Utilized by Comprehensive Glycomics
- 2014 - 2016 Glycoblotting analysis of N-glycans related to diabetic retinopathy
- 2013 - 2016 Exploratory research about intraocular inflammation refractory marker using newly developed carbohydrate structural analysis; Glycoblottoing
- 2012 - 2014 Development of new therapeutic reagents for trypanosoma disease based on the irreversible enzyme inhibition mechanism
- 2010 - 2014 Immune evasion mechanisms from NK immunity by cancer cell-surface O-glycans
- 2010 - 2012 Elucidation of pathological condition in uveitis using newly developed carbohydrate structural analysis; Glycoblottoing
- 2011 - 2011 グライコミクスによる変形性関節症の早期診断に有効な血清糖鎖マーカー探索
- 2008 - 2010 Development of new biomarkers in breast cancer by glycomic profile analyses
- 2006 - 2007 神経組織再生のための新規多機能生体内吸収性基材の開発
- 2005 - 2007 Function search of glycoconjugates by selective laser desorption ionization mass spectronmeter using metal nanoparticle
- 2003 - 2005 Detailed molecular design of artificial extra cellular matrix and application for ligament and cartilage tissue engineering
- 2003 - 2004 神経組織再生のための新規多機能生体内吸収性基材の開発
- 2003 - 2004 乳酸菌表層への化学提示法を用いた経口ワクチンの開発
- 2000 - 2002 Synthetic studies on the glycopeptides drugs
- 1999 - 2001 Joint Research on Preparation of Novel Bioconjugates
- 1999 - 2001 Efficient Synthesis of Glycoconjugates by means of Automated Glycosynthesizer
- 1998 - 2001 Preparation and Utilization of Functional Conjugate Containing Salmon Milt DNA
- 1997 - 2000 Super-Biosystem Constructed by Cognitive Multidimensional Glyco-Molecules
- 1997 - 1999 糖鎖の超精密合成に関する基礎研
- 1998 - 1998 Synthesis of Novel Fluorescent Carbohydrates
- 1997 - 1997 生体基盤材料の開発
- 1995 - 1997 Utilization of DNA as functional materials
- 1996 - 1996 スーパーバイオシステムの高次認識糖鎖分子による構築
- 1993 - 1995 Studies on the biocompatibility of chitosan as biomaterials
- 1994 - 1994 自己組織形成能を有する新しい両親媒性多糖の分子設計
- 1989 - 1989 多糖の分子設計による分離および不斉認識機能の発現
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Papers (407)：
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Ken Murakami, Daiki Kambe, Yasuhiro Yokoi, Hajime Wakui, Shun Hayakawa, Nozomi Hirane, Ryosuke Koide, Michiru Otaki, Noriko Nagahori, Shin-Ichiro Nishimura. Smart Nanomedicine Targeting Endocytosis Mediated by Cancer Cell Surface Neuraminidase-1. Advanced NanoBiomed Research. 2023. 3. 12
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Lareno L. Villones, Anna-Kristin Ludwig, Seiya Kikuchi, Rika Ochi, Shin-Ichiro Nishimura, Hans-Joachim Gabius, Herbert Kaltner, Hiroshi Hinou. Altering the Modular Architecture of Galectins Affects its Binding with Synthetic α-Dystroglycan O-Mannosylated Core M1 Glycoconjugates In situ. ChemBioChem. 2023
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Hajime Wakui, Yasuhiro Yokoi, Chieko Horidome, Toyoyuki Ose, Min Yao, Yoshikazu Tanaka, Hiroshi Hinou, Shin-Ichiro Nishimura. Structural and molecular insight into antibody recognition of dynamic neoepitopes in membrane tethered MUC1 of pancreatic cancer cells and secreted exosomes. RSC Chemical Biology. 2023
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Michiru Otaki, Nozomi Hirane, Yayoi Natsume-Kitatani, Mari Nogami Itoh, Masanori Shindo, Yoichi Kurebayashi, Shin-Ichiro Nishimura. Mouse tissue glycome atlas 2022 highlights inter-organ variation in major N-glycan profiles. Scientific Reports. 2022. 12. 1. 17804
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Lareno L. Villones, Anna-Kristin Ludwig, Hiroyuki Kumeta, Seiya Kikuchi, Rika Ochi, Tomoyasu Aizawa, Shin-Ichiro Nishimura, Hans-Joachim Gabius, Hiroshi Hinou. Exploring the In situ pairing of human galectins toward synthetic O-mannosylated core M1 glycopeptides of α-dystroglycan. Scientific Reports. 2022. 12. 1. 17800
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MISC (226)：
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西村紳一郎, 涌井初, 横井康広. スパイクタンパク質の「動的エピトープ」は新型コロナウイルスの弱点?. 臨床化学. 2021. 50. 4
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西村紳一郎. 理学部で自由に研究できるという最高の幸運に感謝. 彩:理学部創立90周年記念誌. 2020
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西村紳一郎. 現場のアンメットニーズを考える. 臨床化学. 2018. 47. 342-343
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野呂 大輔, 米山 徹, 畠山 真吾, 飛澤 悠葵, 盛 和行, 橋本 安弘, 古家 琢也, 田中 誠一, 西村 紳一郎, 佐々木 秀郎, et al. Screening for serum N-glycan marker associated with early antibody-mediated rejection in patients receiving a living donor kidney transplant. 日本臨床腎移植学会雑誌 = Journal of Japanese Society for Clinical Renal Transplantation. 2017. 5. 1. 71-82
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横井康広, 西村紳一郎. NOTCH1EGFドメインにおけるO-結合型糖鎖修飾の構造および機能. 日本化学会春季年会講演予稿集(CD-ROM). 2017. 97th
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Patents (7)：
Books (14)：
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Glycoscience 2nd Edition. 2115-2119
Springer 2008
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Glycoscience 2nd Edition. 1859-1871
Springer 2008
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糖鎖のMALDI-TOFMSスペクトルデータブック (西村 紳一郎、福島信弘編)
三共出版 2007
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Comprehensive Glycoscience, 453-475
Elsevier Ltd. 2007
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糖鎖のMALDI-TOFMSスペクトルデータブック
三共出版 2007 ISBN:9784782705278
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Lectures and oral presentations (115)：
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The dynamic epitope theory
(The 13th International Polymer Conference (IPC2023) 2023)
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エクソソームのユニークな構造と機能に学ぶ新しい創薬研究への展開
(官民研究開発投資拡大プログラム(PRISM) 「新薬創出を加速する人工知能の開発」 令4元年度成果報告会 2023)
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実践的糖鎖工学プラットフォームの構築と次世代DDSの創成
(第12回GFRGプロジェクトシンポジウム 2023)
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Creation of an innovative drug delivery system targeting pre-metastatic niche
(2022)
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血中エクソソームの由来臓器を糖鎖解析により推定する基盤技術の開発
(官民研究開発投資拡大プログラム(PRISM) 「新薬創出を加速する人工知能の開発」 令和3年度成果報告会 2022)
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Education (3)：
- 1984 - 1987 Hokkaido University
- 1982 - 1984 Hokkaido University
- 1978 - 1982 Hokkaido University
Professional career (1)：
Work history (13)：
- 2019/12 - 現在 遠友ファーマ株式会社
- 2006/04 - 現在 Hokkaido University
- 2012/08 - 2022/03 医化学創薬株式会社
- 2010/11 - 2012/08 医化学創薬合同会社
- 2002/06 - 2010/03 AIST Hokkaido
- 1995/04 - 2006/03 Hokkaido University
- 1993/04 - 1995/03 Hokkaido University
- 1993/07 - 1994/04 Johns Hopkins University 文部省在外研究員
- 1992/04 - 1993/03 Hokkaido University
- 1989/04 - 1992/03 Seikei University
- 1988/04 - 1989/03 RIKEN
- 1987/07 - 1988/03 RIKEN
- 1986/04 - 1987/06 Hokkaido University
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Awards (11)：
- 2024/03 - 公益社団法人高分子学会 令和5年度高分子科学功績賞 複合糖質の高分子科学研究
- 2022/02 - Hokkaido University Hokkaido University President's Award for Excellence in Research and Teaching for AY2022
- 2020/04 - Ministry of Education, Culture, Sports, Science and Technology-Japan MEXT (Minister of Education, Culture, Sports, Science and Technology) Minister’s, Science and Technology for AY2020
- 2009/06 - Cabinet Office 7th Industry-Academia-Government Collaboration Contribution Award
- 2008/11 - The Hokkaido Shimbun Press The Hokkaido Shimbun Culture Prize 2008
- 2006/03 - Japan Association for Chemical Innovation METI (Ministry of Economy, Trade and Industry) Minister’s Award at the GSC Awards for 2006 Automated Glycoconjugate Synthesis by Artificial Golgi Apparatus
- 2005/09 - JST, NEDO Outstanding Performance Awards of UBS Special Award Innovation Japan 2005 Glycan Purification Kit S-Bio BlotGlyco
- 2004/05 - The Society of Polymer Science, Japan The Award of the Society of Polymer Science, Japan Studies on Synthesis of Glycoconjugate
- 1999/03 - The Chemical Society of Japan The Chemical Society of Japan Award for Creative Work for 1998 Development of Efficient Synthesis of Glycoconjugate and Application to Its Functional Analysis
- 1998/07 - The Japanese Society of Carbohydrate Research JSCR (The Japanese Society of Carbohydrate Research) Incentive Awards Functional Analysis of Glycoconjugate and Its Application
- 1997/05 - Johns Hopkins University Membership of the Johns Hopkins Society of Scholars Shin-Ichiro Nishimura
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Association Membership(s) (4)：
アメリカ化学会
, 日本化学会
, 高分子学会
, 日本臨床化学会
