Rchr
J-GLOBAL ID：200901058259897250   Update date: Aug. 23, 2024

Hosokawa Yoshitaka

ホソカワ ヨシタカ | Hosokawa Yoshitaka
Affiliation and department：
Aichi Medical University Department of Biochemistry

About Aichi Medical University Department of Biochemistry


Job title： Professor
Research field  (3)： Tumor biology ,  Hematology and oncology ,  Pathobiochemistry
Research theme for competitive and other funds  (22)：
  • 2022 - 2025 癌抑制遺伝子BAP1を標的とした胸膜中皮種新規阻害薬の開発
  • 2019 - 2023 胸膜中皮腫の予後改善を目指した診断マーカーと阻害化合物の探索
  • 2013 - 2017 Defining the KRAS signaling cascade using a genome-edited human bronchial epithelial cell line
  • 2013 - 2016 Development of a highly specific genome editing technology for human cells using adeno-associated viral vector
  • 2010 - 2012 Characterization of human BRCA1 heterozygous knockout cell lines created by somatic cell gene targeting
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Papers (66)：
  • Sivasundaram Karnan, Ichiro Hanamura, Akinobu Ota, Lam Quang Vu, Kaori Uchino, Tomohiro Horio, Satsuki Murakami, Shohei Mizuno, Md Lutfur Rahman, Md Wahiduzzaman, et al. ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells. Cell death discovery. 2024. 10. 1. 56-56
  • Toshinori Hyodo, Eri Asano-Inami, Satoko Ito, Mai Sugiyama, Akihiro Nawa, Md Lutfur Rahman, Muhammad Nazmul Hasan, Yuko Mihara, Vu Quang Lam, Sivasundaram Karnan, et al. Leucine zipper protein 1 (LUZP1) regulates the constriction velocity of the contractile ring during cytokinesis. The FEBS Journal. 2023
  • Sivasundaram Karnan, Akinobu Ota, Hideki Murakami, Md. Lutfur Rahman, Md Wahiduzzaman, Muhammad Nazmul Hasan, Lam Quang Vu, Ichiro Hanamura, Akihito Inoko, Miho Riku, et al. CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma. Cell Death Discovery. 2023
  • Maho Onda, Akinobu Ota, Kunihiro Ito, Takayuki Ono, Sivasundaram Karnan, Mikako Kato, Sayuri Kondo, Akifumi Furuhashi, Tomio Hayashi, Yoshitaka Hosokawa, et al. Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma. Cancer medicine. 2023
  • Mikako Kato, Akinobu Ota, Takayuki Ono, Sivasundaram Karnan, Toshinori Hyodo, Md Lutfur Rahman, Muhammad Nazmul Hasan, Maho Onda, Sayuri Kondo, Kunihiro Ito, et al. PDZ-binding kinase inhibitor OTS514 suppresses the proliferation of oral squamous carcinoma cells. Oral diseases. 2023
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MISC (198)：
  • SAKAGUCHI Momona, 木村優花, 川村千菜実, 佐伯ななみ, IFTEKHAR Chowdhury Sajid, SIVASUNDARAM Karnan, 細川好孝, 花村一朗, 太田明伸, 太田明伸. Differential effect of free fatty acids on the survival of multiple myeloma cells. International Journal of Myeloma (Web). 2024. 14. 3
  • 太田明伸, 太田明伸, 花村一朗, シバスンダラン カルナン, シバスンダラン カルナン, 武井則雄, IFTEKHAR Chowdhury Sajid, 兵頭寿典, 小西裕之, 都築忍, et al. A novel FIRRM-FIGNL1 interaction enhances the viability of multiple myeloma cells. International Journal of Myeloma (Web). 2024. 14. 3
  • HYODO Toshinori, HASAN Muhammad Nazmul, BISWAS Mrityunjoy, INAMI Eri, KARNAN Sivasundaram, OTA Akinobu, TSUZUKI Shinobu, HOSOKAWA Yoshitaka, KONISHI Hiroyuki. LUZP1, a novel CPC colocalizing protein, regulates the constriction velocity of the contractile ring during cytokinesis. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
  • HASAN Muhammad Nazmul, HYODO Toshinori, BISWAS Mrityunjoy, RAHMAN MD. Lutfur, MIHARA Yuko, KARNAN Sivasundaram, OTA Akinobu, TSUZUKI Shinobu, HOSOKAWA Yoshitaka, KONISHI Hiroyuki. A Rapid and Sensitive FCM-Based Assay for Monitoring CRISPR/Cas9 Genome Editing in L1CAM Gene. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
  • 太田明伸, 太田明伸, カルナン シバスンダラン, 小西裕之, 都築忍, 細川好孝, 風岡宜暁. OTS514 suppresses the tumor growth with concomitant downregulation of E2F target genes in oral squamous carcinoma cells. 日本癌学会学術総会抄録集(Web). 2023. 82nd
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Education (4)：
  • - 1990 名古屋大学医学部医学科大学院博士課程生化学専攻 医学系研究科 生化学
  • - 1990 Nagoya University School of Medecine, Department of Biochemistry Graduate School, Division of Medical Sciences Biochemistry
  • - 1986 Nagoya University School of Medicine
  • - 1986 Nagoya University Faculty of Medicine
Professional career (1)：
  • Medecal Doctor (Nagoya University)
Work history (7)：
  • 2000 - :愛知県がんセンター研究所遺伝子医療研究部室長
  • 2000 - Aichi Cancer Center, Div. of Molecular Medecine,
  • 1997 - :愛知県がんセンター研究所化学療法部室長
  • 1993 - :米国ハーバード大学医学部マサチューセッツ総合病院
  • 1990 - :三重大学医学部生化学講座助手
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Association Membership(s) (4)：
日本分子生物学会 ,  日本生化学会 ,  日本血液学会 ,  日本癌学会
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