Rchr

J-GLOBAL ID：200901058286263000 Update date: Nov. 05, 2024

Takao Keizo

タカオケイゾウ | Takao Keizo

Affiliation and department：
Job title： Professor
Other affiliations (10)：

University of Toyama Life Science Research Center Director of the Division of Animal Resources and Development
University of Toyama Graduate School of Innovative Life Science Dean
University of Toyama Graduate School of Pharma-Medical Sciences, Program of Cognitive and Emotional Neuroscience Chair
University of Toyama Life Science Research Center Director of the Division of Radioisotope and Radiation Research
University of Toyama School of Medicine Professor

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Homepage URL (1)： http://www.lsrc.u-toyama.ac.jp/larc/larc_labo.htm

Research field (6)： Basic brain sciences , Neuroscience - general , Laboratory animal science , Experimental psychology , Genomics , Other

Research keywords (28)：自閉スペクトラム症 , うつ病 , AdAMS , 先端モデル動物支援プラットフォーム , 統合失調症 , 神経発達障害 , モデルマウス , モデル動物 , 呼吸法 , 瞑想 , 実験動物学 , 放射線医学 , MRI , ゲノム合成 , 行動生理学 , 武道 , 合気道 , 東洋医学 , 包括脳ネットワーク , 精神疾患 , 神経疾患 , 脳・神経 , 蛍光タンパク質 , ゲノム編集 , 遺伝子改変マウス , 網羅的行動テストバッテリー , 未病 , 行動学

Research theme for competitive and other funds (40)：

2022 - 2028 先端モデル動物支援プラットフォーム
2022 - 2026 Analysis of the effects of microglia on the developing brain
2021 - 2024 Noninvasive visualization of change in temperature in living body using ultrasound
2021 - 2024 Production of a bipolar model mice and clarification of the neuronal mechanism of the manic switch
2021 - 2024 血小板由来増殖因子による脳の老化制御機構の解明

2019 - 2024 脳内炎症が引き起こすRNA編集異常が精神疾患様行動異常をもたらす機構の解明

2018 - 2023 Mechamisms underlying information processing in idling brain

2019 - 2021 Development of animal model of breathing method and the application for willdynamics

2018 - 2021 Elucidation of the role of organelle stress response in oral cancer stem cells

2016 - 2021 先端モデル動物支援プラットフォーム

2017 - 2019 呼吸法の動物モデル確立とその意志動力学への応用

2016 - 2019 Investigation of psychiatric disorders as a disruption of homeostasis

2019 - 2019 免疫機能不全が脳機能に与える影響の解明-免疫不全マウスの網羅的行動解析-

2016 - 2018 幼児性健忘における歯状回成熟度の意義の解明

2016 - 2018 Screening for functional protein-encoding ORFs located outside coding regions in the human genome

2015 - 2018 Molecular network and physiological function of glutamatergic tripartite synapse in the cerebellum

2015 - 2018 Identification of the mechanisms of metabolic stress signal for the treatment of oral cancer

2015 - 2018 Elucidating synaptic mechanisms and treatment of epileptic encephalopathy associated with CDKL5 mutations

2015 - 2018 Research on Fukuyama musucular dystrophy towards clincal trial using antisense oligonucleotids

2013 - 2018 Elucidation and regulation of bi-directional changes in neuronal maturation status

2014 - 2017 Analyses of an orphan metabotropic receptor which plays a role in the long term retention of memory, and a secretory protein encoded by its splice variant

2014 - 2016 Exploring the relationship between altered neuronal maturation state in the hippocampal dentate gyrus and behavior

2010 - 2016 Comprehensive Brain Science Network

2014 - 2015 幼児性健忘における歯状回成熟度の意義の解明

2013 - 2015 Investigation of psychiatric disorders as a disruption of homeostasis

2011 - 2014 Physiological roles of BRINP family proteins on neuronal development

2010 - 2014 Functional analysis of the molecular markers of the growth cone

2010 - 2011 Behavioral and functional analysis of Shn2 gene using site-and time-specific gene targeting technique

2009 - 2011 Dysregulated behaviors caused by temporally and brain region-specific knockout of CaMKIIα

2008 - 2010 Physiological roles of BRINP family proteins in neuronal development and survival

2008 - 2009 ENU変異マウスを用いた行動異常発症に関わる遺伝子の機能解析

2008 - 2009 ヒト、マウスにおける神経細胞特異的インプリンティング遺伝子の探索

2007 - 2009 Regulation of synaptic transmission by the scaffolding protein PSD-95

2005 - 2009 Elucidation of molecular pathomechanisms of schizophrenia

2007 - 2008 遺伝子改変マウスの高速表現型解析のための全自動8ノ字型迷路課題の確立

2006 - 2007 ジーンドリブン・ミュータジェネシス法を用いたカルシニューリン関連遺伝子の機能解析

2006 - 2007 統合失調症のカルシニューリン仮説に基づいた統合失調症発症メカニズムの解明

2006 - 2007 各種グリア細胞関連遺伝子の遺伝子改変マウスの網羅的行動解析

2006 - 2007 行動異常を示す遺伝子改変マウスにおける樹状突起スパインの動態解析

2000 - 2002 多電極基板上の分散培養ニューロンによる神経回路自己組織化

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Papers (132)：

Jelena Borovac, Jayant Rai, Megan Valencia, Hang Li, John Georgiou, Graham L Collingridge, Keizo Takao, Kenichi Okamoto. Optogenetic elevation of postsynaptic cGMP in the hippocampal dentate gyrus enhances LTP and modifies mouse behaviors. Frontiers in Molecular Neuroscience. 2024. accepted
Hiroaki Taketsuru, Runa Hirayama, Ena Nakatsukasa, Rie Natsume, Keizo Takao, Manabu Abe, Kenji Sakimura. Generation of rat offspring from ovarian oocytes by xenotransplantation. Scientific reports. 2024. 14. 1. 20109-20109
Feng Yang, He You, Toshiyuki Mizui, Yasuyuki Ishikawa, Keizo Takao, Tsuyoshi Miyakawa, Xiaofei Li, Ting Bai, Kun Xia, Lingling Zhang, et al. Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo. Molecular psychiatry. 2024
Mizuki Sadakata, Kazuki Fujii, Ryosuke Kaneko, Emi Hosoya, Hisako Sugimoto, Reika Kawabata-Iwakawa, Tetsuhiro Kasamatsu, Shoko Hongo, Yumie Koshidaka, Akinori Takase, et al. Maternal immunoglobulin G affects brain development of mouse offspring. Journal of neuroinflammation. 2024. 21. 1. 114-114
Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, et al. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. eLife. 2024. 12. RP89376

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MISC (93)：

Kazuki Fujii, Keizo Takao. 行動テストバッテリーによるマウスの行動表現型解析とその応用. SEITAI NO KAGAKU. 2024. 75. 5. 456-457
長谷川英之, 竹内道雄, 大村眞朗, 長岡亮, 高雄啓三. 超音波散乱波の振幅統計量にもとづく生体組織内温度変化の検出. 超音波TECHNO. 2024. 36. 1. 48-51
高雄啓三 “脳・神経”からみた多田宏師範の合気道心と身体を同化する神経系統訓練法. 月刊「秘伝」. 2023. 2023年7月号
Keizo Takao. The Significance of Budo as Seen from the Viewpoint of Academic Institute. Budo. 2019. 635. 2019年10月号. 74-79
吉田知之, 山形敦史, 田端彩子, 和泉宏謙, 城島知子, 金主賢, 深田優子, 深田正紀, 高雄啓三, 森寿, et al. 遺伝子点変異による精神神経疾患の発症機構解明シナプスオーガナイザー遺伝子点変異導入マウスを用いた神経発達障害発症機構の解明. 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集. 2017. 39回・47回. 82-82

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Patents (1)：

Gm1遺伝子産物欠損非ヒト動物及びその利用法

Books (9)：

マウス・ラットモデル作製・解析プロフェッショナル : あなたの研究をステップアップさせる最新・最適手技
羊土社 2021 ISBN:9784758121125
バイオ実験を安全に行うために
KAGAKUDOJIN 2018 ISBN:4759819215
基礎心理学実験法ハンドブック
Asakura Publishing Co.,Ltd. 2018 ISBN:4254520239
改訂第3版脳神経科学イラストレイテッド〜分子・細胞から実験技術まで
Youdosha 2013 ISBN:4758120404
安全性薬理試験マニュアル
Life Science Information center 2009 ISBN:9784900487468

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Lectures and oral presentations (14)：

Investigations of neuropsychiatric disorders using reproductive engineering and behavioral analysis of mice.
(Scientific Conference on 75-year Anniversary of the Establishment of Vietnam military Medical University 2024)
自閉症スペクトラム障害の基礎研究: マウスの生殖工学と行動解析を活用した神経発達障害研究
(「自閉症スペクトラム障害の理論・基礎・臨床~病態の神経・生理心理学的基盤をめぐる最新の研究動向」日本心理学会第87回大会 2023)
マウスの生殖工学と行動解析を活用した神経発達障害研究
(『多様な病因に潜む共通メカニズムから探る神経発達障害のネオパソロジー』第45回日本分子生物学会年会)
マウスにおけるゲノム編集と行動解析を起点とした精神疾患研究
(東京理科大学第7回パラレル脳研究部門勉強会・セミナー 2022)
マウス行動解析、その前と後
(先端モデル動物支援プラットフォーム 2021年度若手支援技術講習会 2021)

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Education (5)：

2000 - 2003 Kyoto University Graduate School of Informatics Department of Intelligence Science and Technology, Doctor's Program
1998 - 2000 Kyoto University Graduate School of Informatics Department of Intelligence Science and Technology, Master's course
1996 - 1998 The University of Tokyo Faculty of Letters Department of Psychology
1994 - 1996 The University of Tokyo College of Arts and Sciences: Junior Division Natural Sciences II
1991 - 1994 Taki Senior High School

Professional career (2)：

PhD in Informatics (Kyoto University)
PhD in Medical Sciences (University of Toyama)

Work history (26)：

2023/04 - 現在 University of Toyama Graduate School of Innovative Life Science Dean
2022/04 - 現在 University of Toyama
2022/04 - 現在 University of Toyama Graduate School of Pharma-Medical Sciences Program Chief
2022/04 - 現在 University of Toyama
2020/10 - 現在 University of Toyama Research Center for Presymptomatic Disease

2020/04 - 現在 University of Toyama Research Center for Idling Brain Science

2019/10 - 現在 University of Toyama Faculty of Medicine Professor

2019/04 - 現在 University of Toyama Life Science Research Center Director of the Division of Radioisotope and Radiation Research

2017/01 - 現在 University of Toyama Graduate school of Innovative Life Sciences Professor

2015/11 - 現在 University of Toyama Department of Behavioral Physiology, Graduate school of Medicine and Pharmaceutical Sciences Professor

2015/10 - 現在 University of Toyama Life Science Research Center Director of the Division of Animal Resources and Development,

2015/10 - 現在 University of Toyama Life Science Research Center, Organization for Promotion of Research Professor

2021/04 - 2023/03 University of Toyama Graduate school of Innovative Life Sciences Vice Dean

2019/04 - 2021/03 University of Toyama Graduate school of Innovative Life Sciences Chair of Major of Cognitive and Emotional Neuroscience Course

2018/04 - 2019/09 University of Toyama Graduate school of Medicine and Pharmaceutical Sciences, Faculty of Medicine Professor

2015/10 - 2017/03 National Institute for Physiological Sciences Center for Genetic Analysis of Behavior Professor (concurrent)

2013/05 - 2015/09 The Graduate University for Advanced Studies, SOKENDAI School of Life Science Associate Professor

2010/04 - 2015/09 National Institute for Physiological Sciences Center for Genetic Analysis of Behavior Project Associate Professor

2009/04 - 2010/03 Kyoto University Career-Path Promotion Unit for Young Life Scientists lecturer

2007/04 - 2009/03 京都大学医学研究科先端技術センター客員研究員

2007/04 - 2009/03 Fujita Health University Institute for Comprehensive Medical Science Assistant professor

2005/09 - 2007/03 Kyoto University Horizontal Medical Research Organization Assistant professor

2006/01 - Kyoto University Ph.D.

2003/04 - 2005/08 RIKEN Special Postdoctoral Researcher

2001/10 - 2005/08 Massachusetts Institute of Technology Center for Learning and Memory Visiting scholar

2000/04 - 2003/03 The Japan Society for the Promotion Research Fellow

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Committee career (5)：

2023/10 - 現在北陸実験動物研究会会長
2023/04 - 現在 The Japan Neuroscience Society Councilor
2020/04 - 現在若手・中堅脳科学研究者のオンライン勉強会世話人
2019/04 - 現在日本神経精神薬理学会評議員
2017/12 - 現在 Molecular Brain Editorial Board Member

Awards (4)：

2023/06 - 第77回日本栄養・食糧学会大会トピックス賞妊娠期における必須脂肪酸の摂取バランスが仔の行動に及ぼす影響の網羅的解析
2022/10 - JSNP NPPR Article Award 2022 Effects of chronic fentanyl administration on behavioral characteristics of mice.
2014/12 - 包括型脳科学研究推進支援ネットワーク平成26年度包括型脳科学研究推進支援ネットワーク冬のシンポジウム若手優秀発表賞
2012/06 - 28th CINP (The International Behavioural and Neural Genetics Society) World Congress of Neuropsychopharmacology, JSNP Excellent Presentation Award for CINP 2012

Association Membership(s) (8)：

JAPANESE SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE , Molecular and Cellular Cognition Society , SOCIETY FOR NEUROSCIENCE , THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY , JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE , THE JAPANESE PSYCHOLOGICAL ASSOCIATION , THE JAPAN NEUROSCIENCE SOCIETY , THE PHYSIOLOGICAL SOCIETY OF JAPAN

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