Koseki Takeyoshi

2022 - 2025 Creation of a dental skill distance education system incorporating a clinical skill AI evaluation engine

2020 - 2023 Development of risk assessment system of dental caries based upon hardness of hard tissue and remineralization method of enamel surfaces

2020 - 2023 標的指向性マイクロバブルと金属ナノ粒子及び低出力超音波を用いた口腔癌治療法の確立

2019 - 2022 Development of a comprehensive reconstruction of the oral environment by detailed physicochemical and functional analysis of saliva

2018 - 2022 Development of predictive oral supportive system for perioperative breast cancer patients

2015 - 2018 Exhaustive survey of development of oral function and health promotion factors on a large-scale birth cohort

2015 - 2018 The comprehensive survey for the risk factor of oral mucositis under the radiotherapy.

2015 - 2018 Comprehensive analysis in oral microbiome as a promoting factor for esophageal cancer

2014 - 2017 Guideline for the early diagnosis of residual ridge by using NaF-PET/CT and FEA

2014 - 2017 Development of new evaluation system of mucosal inflammation based upon vascular imaging and preventive method of oral mucositis with oral mucosa mapping system

2014 - 2017 Metabolome analysis of oral biofilm: a possible risk assessment of oral diseases using oral microbiome metabolism

2015 - 2016 ナノ・マイクロバブルと超音波を用いた歯質へのフッ素導入法の開発

2014 - 2016 Establishment of new research platform of functional salivary proteins with comprehensive proteasome analysis

2013 - 2016 Proposal of the guideline for the treatment and rehabilitation of the neck and head cancer based on the healing processes of soft tissues

2013 - 2016 Establishment of the concept of rehabilitation with the oral caring with the effect of mental healing and recovery

2013 - 2016 Correlation between periodontal bacteria and progression of aortic aneurysm

2013 - 2015 Development of artificial saliva-secreting automated device placed inside the mouth activated by oral environment and functional activities

2011 - 2014 Development and proposal of evaluation method of oral mucosal damages based on the degree of injuries and atrophy of oral mucosa and saliva properties

2010 - 2014 Metabolomic approach to oral biofilm and saliva: possible risk indicator for oral diseases

2011 - 2013 Parameters of oral environment for perioperative patients of lung cancer based on two dimensional analysis of breath gasses

2011 - 2012 Development of the debridement method of soft and hard tissues with novel functional strings

2011 - 2012 Clinical application of assessment devices for the risk of dental caries with ultrasonic haptic sensor technology

2009 - 2011 Study about the current state of environmental pollution and prevention control caused by formaldehyde mixture at dental clinics

2008 - 2010 Development of diagnostic system of gingivitis based upon the objective index of peripheral vessel of inflamed tissues

2008 - 2010 Two dimensional evaluation by volatile gases for oral condition of diabetes mellitus

2008 - 2010 Development of accelerated remineralization method based upon the non-invasive assessment of mineral density of tooth

2008 - 2009 パウダージェット法と硬組織自己再構成法による瞬時小窩裂溝填塞術の開発

2007 - 2009 Metabolome analysis of oral biofilm using CE-TOFMS and its application possibility as an oral health indicator

2006 - 2007 Tonometoryによる新しいデジタル歯肉炎診断システム

2005 - 2007 口腔微生物叢の「揺りかご」:舌苔バイオフィルムの生物学

2005 - 2007 The study of the association of immune related genotypes with dental caries in Japanese individuals

2005 - 2006 レーザー光による初期病変の齲蝕活動性診断器の開発とその臨床的応用の検討

2005 - 2006 Establishment of the diagnostic criteria of root caries and the method for its remineralization based on the optical and physical properties of root surfaces

2004 - 2005 Effect of IL-10 over-expression on bone resorption mechanism in apical periodontitis

2003 - 2004 DNAチップを用いた口腔微生物叢の網羅的定量的プロファイリング

2003 - 2004 Development of an ultrasonic device to detect early demineralized lesions and establishment of clinical criteria for these diagnoses

2002 - 2004 STUDY OF THE PATHOGENESIS AND PHYSICAL NATURE OF DENTAL BIOFILM

2001 - 2002 Development of prevention method of periodontal diseases by understanding the mechanisms of intracellular invasion by periodontopathic bacteria

2000 - 2002 Analysis of Destruction Mechanisms of Dental Biofilm by Laser and Its Clinical Application

1999 - 2000 感染マクロファージのアポトーシスの関与するカスパーゼファミリーの解析

1999 - 2000 Analysis of apoptosis in alveolar macrophages induced by periodontopathic bacteria and development of a method of protection from pneumonia