Rchr
J-GLOBAL ID：200901058802361048   Update date: Nov. 05, 2024

Mizobata Tomohiro

ミゾバタ トモヒロ | Mizobata Tomohiro
Affiliation and department：
Tottori University Faculty of Engineering, Department of Chemistry and Biotechnology

About Tottori University Faculty of Engineering, Department of Chemistry and Biotechnology


Other affiliations (1)：
  • Tottori University  Graduate School of Medical Sciences, Major in Regenerative Medicine and Biofunction, Department of Biomedical Science   Associate Professor
Homepage URL  (1)： http://researchers.adm.tottori-u.ac.jp/html/100000572_ja.html
Research field  (3)： Biophysics ,  Structural biochemistry ,  Molecular biochemistry
Research keywords  (37)： HdeA ,  Periplasm ,  シャペロニン ,  分子シャペロン ,  GroEL ,  GroE ,  蛍光 ,  蛋白質フォールディング ,  ストップト・フロー ,  フォールディング ,  熱ショック蛋白質 ,  ストップト・フロー分光法 ,  古細菌 ,  円順列変異 ,  部位特異的変異導入 ,  超好熱性 ,  部位特異的変異導入法 ,  機能発現機構 ,  コンフォメーション変化 ,  αシヌクレイン ,  アミロイド線維 ,  構造安定性 ,  立体構造形成 ,  アミロイド線維形成 ,  オリゴマー蛋白質 ,  GroES ,  脳神経変性病 ,  アミロイド様線維形成 ,  シャペロニンGroES ,  耐熱性シャペロニン ,  安定性 ,  ストレス蛋白質 ,  Structural Biological Chemistry ,  Protein Engineering ,  Protein Folding ,  タンパク質化学 ,  Protein Chemistry
Research theme for competitive and other funds  (22)：
  • 2019 - 2022 E. coli HdeA: Analysis of the reversible formation of fibrils by an environmentally responsive molecular chaperone
  • 2013 - 2016 Evaluation of cytotoxicity and control of protein aggregation in the amyloid fibril formation
  • 2013 - 2015 Re-evaluation of the molecular mechanism of chaperonin action: characterization of circularly-permuted GroEL
  • 2010 - 2012 Functional and kinetic analysis of the inter-domain communication network of the chaperonin GroEL
  • 2009 - 2011 Structural and functional characteristics of natively unfolded protein
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Papers (82)：
  • Kazuya Matsuo, Sefan Asamitsu, Kohei Maeda, Hiroyoshi Suzuki, Kosuke Kawakubo, Ginji Komiya, Kenta Kudo, Yusuke Sakai, Karin Hori, Susumu Ikenoshita, et al. RNA G-quadruplexes form scaffolds that promote neuropathological α-synuclein aggregation. Cell. 2024
  • Yasushi Yabuki, Kazuya Matsuo, Ginji Komiya, Kenta Kudo, Karin Hori, Susumu Ikenoshita, Yasushi Kawata, Tomohiro Mizobata, Norifumi Shioda. RNA G-quadruplexes and calcium ions synergistically induce Tau phase transitionin vitro. 2024
  • Hanae Yamamoto, Rio Matsumura, Miho Nakashima, Mayuka Adachi, Kenjirou Ogawa, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata. Effects of the Polyphenols Delphinidin and Rosmarinic Acid on the Inducible Intra-cellular Aggregation of Alpha-Synuclein in Model Neuron Cells. Applied Biochemistry and Biotechnology. 2023
  • An Cheng, Yi-Fei Wang, Yasuharu Shinoda, Ichiro Kawahata, Tetsunori Yamamoto, Wen-Bin Jia, Hanae Yamamoto, Tomohiro Mizobata, Yasushi Kawata, Kohji Fukunaga. Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress. Acta pharmacologica Sinica. 2021. 43. 3. 552-562
  • Naoya Fukui, Hanae Yamamoto, Moe Miyabe, Yuki Aoyama, Kunihiro Hongo, Tomohiro Mizobata, Ichiro Kawahata, Yasushi Yabuki, Yasuharu Shinoda, Kohji Fukunaga, et al. An α-synuclein decoy peptide prevents cytotoxic α-synuclein aggregation caused by fatty acid binding protein 3. Journal of Biological Chemistry. 2021. 296. 100663-100663
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MISC (43)：
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Lectures and oral presentations  (5)：
  • The structural landscape of the periplasmic molecular chaperones HdeA and HdeB: Acid induced activation of molecular chaperone activity and fibrillar aggregation
    (International Symposium on Disordered Proteins, Protein Folding, and Disease-causing Aggregation (The 10th Asia-Pacific IDP Symposium) 2019)
  • The reversible formation of atypical fibrils by the E. coli heat shock protein HdeA
    (The 9th KRIBB Asia-Pacific IDP Symposium "Where are we with IDPs" 2018)
  • Chaperonin Engineering; Three examples of utilizing the unique characteristics of E. coli GroEL in engineering and medicine
    (ConBio2017 Consortium of Biological Sciences 2017 2017)
  • Two examples of persistent fibrillogenesis: functionally denatured molecular chaperones and alpha-synuclein
    (THE 8th KRIBB ASIA-PACIFIC IDP SYMPOSIUM “Multidisciplinary approaches for IDPs” 2017)
  • Molecular chaperones and fibrillogenesis: interactions between fibril-forming denatured polypeptides and broad-specificity bacterial chaperones
    (7th KRIBB Asia-Pacific IDP Symposium 2016)
Education (4)：
  • - 1994 Kyoto University
  • - 1992 Kyoto University Graduate School, Division of Natural Science
  • - 1990 Kyoto University Faculty of Science
  • - 1990 Kyoto University Faculty of Science
Professional career (2)：
  • Master's Degree in Science (Kyoto University)
  • Doctor of Philosophy(Science) (Kyoto University)
Work history (5)：
  • 2019 - 現在 Tottori University
  • 2001 - 2019 Graduate School of Engineering, Tottori University Associate Professor
  • 2010 - 2013 Tottori University
  • 1994 - 2001 Tottori University
  • 1994 - 2001 Tottori University, Research Assistant
Association Membership(s) (5)：
The Protein Society ,  THE SOCIETY FOR BIOSCIENCE AND BIOENGINEERING, JAPAN ,  PROTEIN SCIENCE SOCIETY OF JAPAN ,  THE BIOPHYSICAL SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY
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