Matsuda Fumihiko

マツダフミヒコ | Matsuda Fumihiko

Homepage URL (1)： https://www.genome.med.kyoto-u.ac.jp/

Research field (1)： Molecular biology

Research keywords (3)： Genomic Medicine , Human Genetics , Molecular Biology

Research theme for competitive and other funds (42)：

2021 - 2026 Interdisciplinary cohort study for comprehensive understanding of pathophysiology of frailty
2022 - 2025 進行性線維化を伴う間質性肺疾患における新規臨床指標の開発と治療標的の探索
2020 - 2023 Cross-sectional and prospective study with metabolome analysis to detect pathophysiology about the relationship between deterioration in lung function and sleep disordered breathing
2020 - 2023 生体肺移植におけるドナー、レシピエントの末梢血テロメア長と慢性移植肺機能不全
2019 - 2022 Pathogenesis of pleuroparenchymal fibroelastosis

2017 - 2022 Interdisciplinary epidemiological study to better understand the multiple linkages between frailty and potential organ damage

2017 - 2020 Multicenter study for peripheral blood telomere length in patients with idiopathic pulmonary fibrosis

2017 - 2020 Investigation of omics analysis and detection of biomaker to patients with airway disease progression and sleep disturbance

2015 - 2020 Development of a treatment depression with mixed feature by a biomarker-based randomized controlled trial

2015 - 2019 Identification of genetic and environmental risk factors for moyamoya disease

2015 - 2018 Analysis of human senescence-related T cells using cohort study

2015 - 2017 Challenging study of molecular mechanisms in pineal parenchymal tumor

2014 - 2017 Establishment of utilized predictive biomarkers of chemo sensitivity for ovarian cancer patients

2014 - 2017 Developments of new therapies following investigations of the effects of sleep disturbance on secular changes in airway and systemic diseases

2013 - 2017 Epidemiology of frailty in older people

2013 - 2016 Understanding and overcoming drug resistance to EGFR-inhibitors for lung cancer

2013 - 2015 MS imaging Analysis to identify protein expressions regulating malignant transformation in glioma

2010 - 2011 Genome-wide association study for rheumatoid arthritis using a large prospective cohort: a pilot study for personalized medicine.

2009 - 2010 Pharmacogenetic study to predicting clinical response of oxaliplatin in patients with advanced colorectal cancer

2008 - 2010 HTLV-1関連疾患にかかわる遺伝因子の探索

2008 - 2009 ゲノムワイドアプローチを用いた日本人成人性T細胞白血病の感受性遺伝子・多型の探索

2005 - 2009 The genetic epidemiology of cerebrovascular disease with high risk genetic factors to establish the secondary prevention program targeting high risk subjects

2007 - 2008 Pharmacogenetic analysis of clinical response to oxaliplatin-based Chemotherapy in colorectal cancer patients

2006 - 2008 Host gene polymorphisms associated with HIV-transmission and AIDS-progression among HIV-1-infected individuals in northern Thailand

2006 - 2007 成人性T細胞白血病の遺伝因子の解明:DNA修復遺伝子の多型の遺伝解析

2005 - 2005 ヒトDNA修復遺伝子の一塩基多型の遺伝解析と生物学的機能の評価

2004 - 2004 ニワトリB細胞株を用いたヒトDNA修復遺伝子のSNPの機能評価

2004 - 2004 日仏共同研究によるDNA修復遺伝子の多人種間での比較SNPデータベース構築

1997 - 1998 The Complete Nucleotide Sequence of the Human Immunoglobulin Heavy Chain Variable Region Locus

1996 - 1998 Production of recombinant autoantibodies

1996 - 1997 Application of Ig genes encoding anti-TSH receptor autoantobodies.

1996 - 1997 New genetic markers for Graves disease

1995 - 1997 Japan-French Joint Research on Genome

1996 - 1996 ヒト免疫グロブリンH鎖遺伝子全領域の構造解析

1995 - 1996 Organization and evalution of the human immuno-globulin heavy-chain V region genes

1995 - 1995 IgG型抗TSH受容体自己抗体遺伝子の解析とその応用

1994 - 1995 Structural analysis of the human immunoglobulin H-chain locus

1994 - 1994 ヒト免疫グロブリン遺伝子群の分子進化学的解析

1993 - 1994 Isolation, analysis and constitution of Immunoglobulin encoding autoantibodies

1990 - 1991 Molecular mechanisms for immunoglobulin class switching

抗体の多様性の分子機構生活習慣病の遺伝要因の解明

Molecular mechanisms of antibody diversity, Gene identification of multigenetic disorders

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Papers (492)：

Takeshi Iwasaki, Ryu Watanabe, Hiromu Ito, Takayuki Fujii, Koichiro Ohmura, Hiroyuki Yoshitomi, Koichi Murata, Kosaku Murakami, Akira Onishi, Masao Tanaka, et al. Monocyte-derived transcriptomes explain the ineffectiveness of abatacept in rheumatoid arthritis. Arthritis Research and Therapy. 2024. 26. 1
Takeshi Iwasaki, Yoichiro Kamatani, Kazuhiro Sonomura, Shuji Kawaguchi, Fumihiko Matsuda. Protocol for genome-wide association study of human blood metabolites. STAR Protocols. 2024. 5. 2. 103052-103052
Maria J Knol, Raymond A Poot, Tavia E Evans, Claudia L Satizabal, Aniket Mishra, Muralidharan Sargurupremraj, Sandra van der Auwera, Marie-Gabrielle Duperron, Xueqiu Jian, Isabel C Hostettler, et al. Genetic variants for head size share genes and pathways with cancer. Cell reports. Medicine. 2024. 101529-101529
Pavithra Nagarajan, Thomas W Winkler, Amy R Bentley, Clint L Miller, Aldi T Kraja, Karen Schwander, Songmi Lee, Wenyi Wang, Michael R Brown, John L Morrison, et al. A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations. medRxiv : the preprint server for health sciences. 2024
Takeshi Iwasaki, Ryu Watanabe, Hui Zhang, Motomu Hashimoto, Akio Morinobu, Fumihiko Matsuda. Identification of the VLDLR locus associated with giant cell arteritis and the possible causal role of low-density lipoprotein cholesterol in its pathogenesis. Rheumatology. 2024

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MISC (136)：

小林牧, 若栗浩幸, 清水正和, 日笠幸一郎, 松田文彦, 本庶佑. Ago2- and a miRNA-dependent control of topoisomerase 1 (TOP1) by activation-induced cytidine deaminase (AID) for antibody memory formation. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
小林牧, 若栗浩幸, 清水正和, 日笠幸一郎, 松田文彦, 本庶佑. Ago2とmiRNAはAID依存性の抗体遺伝子組換えにおけるDNA切断を促進するためにDNAトポイソメラーゼ1を減少させる. 日本生化学会大会(Web). 2023. 96th
磯村望, 南野寛人, 池田香織, 吉治智志, 田中大祐, 藤田義人, 田原康玄, 松田文彦, 稲垣暢也. 食品摂取の多様性の増加は、脂肪肝指数の低下と関連する地域住民コホートながはまスタディからの報告. 日本病態栄養学会誌. 2023. 26. Suppl. S-3
西健太, 長崎忠雄, 松本久子, 小熊毅, 寺田悟, 野村奈都子, 古郷摩利子, 砂留広伸, 村瀬公彦, 川口喬久, et al. 気管支喘息(成人):長期追跡調査、増悪因子高齢者・非高齢者における喘息発症因子の差異ながはま疫学研究. アレルギー. 2022. 71. 6-7. 822-822
長崎忠雄, 佐藤晋, 村瀬公彦, 松本健, 濱田哲, 砂留弘伸, 十川純平, 高橋順美, 田原康玄, 松田文彦, et al. 日本におけるCOPDと睡眠呼吸障害の関連ながはまコホート研究より. 日本睡眠学会定期学術集会プログラム・抄録集. 2022. 47回. 207-207

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Professional career (2)：

Doctor of Medicine
Master of Medical Science

Awards (3)：

2016/05 - Ilchun Genomic Medicine Award by Korean Society of Biochemistry and Molecular Biology
2000/11 - 'Award of Japanese Society for Immunology' by Japanese Society for Immunology
2000/09 - Young Investigator Award by the Japanese Biochemical Society

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