Komatsu Norio

2020 - 2023 本態性血小板血症に特異的な転写ネットワークによる細胞腫瘍化メカニズムの解明

2019 - 2022 変異型CALRのホモ多量体化を標的とした治療概念の確立

2018 - 2021 ERストレスを介した新規骨髄線維症腫瘍クローン廃絶法の開発

2018 - 2021 CALR遺伝子変異により発症する骨髄増殖性腫瘍に対する新規治療戦略の開発

2017 - 2020 家族内発症例の遺伝的要因の同定を基盤とした骨髄増殖性腫瘍発症機序の解明

2017 - 2020 本態性血小板血症の遺伝子情報に基づく個別化治療の実現

2016 - 2019 Elucidation of molecular mechanism of cytokie receptor activation by mutant CALR

2015 - 2019 Selective elimination of tumor clones of primary myelofibrosis based on drug repositioning

2016 - 2018 Establishment of in vitro model for essential thrombocythemia by mutant calreticulin

2015 - 2018 Establishment of therapeutic mAbs for malignant lymphoma

2015 - 2018 Identification of promising marker(s) for essential thrombocythemia diagnosis by differential gene expression approach

2013 - 2016 A novel approach for monitoring the minimal residual disease in chronic myeloid leukemia

2013 - 2015 Sirtuin阻害による急性前骨髄球性白血病細胞の分化誘導

2011 - 2013 ATRAによるAPL細胞の分化誘導の分子メカニズム

2011 - 2013 Development of the new treatment strategy of ATRA-resistant APL using PP2A-FOXO3A activation pathway

2009 - 2011 Hypoxia attenuates growth of MPN cells through suppression of SHP-2 expression and subsequent inhibition of JAK2V617F activity

2008 - 2010 Analysis of the mechanisms of RUNX1 gene regulation in the pathogenesis of leukemia

2007 - 2008 Role of glucose metabolism in hematological malignancy

2006 - 2008 Development of novel therapeutic strategy for targeting transcription factors expressed in cancer stem cells

2005 - 2006 Thrombopoietin (TPO) regulates HIF-la levels through generation of mitochondrial reactive oxygen species

2005 - 2006 ホメオボックスHOXA9によるHOXB4の機能抑制と白血病発症

2005 - 2005 抗白血病薬によるTRAIL発現誘導と薬剤感受性

2003 - 2005 The development of targeted therapies using FKHRL1 for the treatment of leukemia

2004 - 2004 FKHRL1による白血病細胞増殖抑制機構

2003 - 2003 白血病細胞のdormancy誘導におけるFKHRL1転写因子の役割

2002 - 2003 Role of STAT5 in regulation of hematopoietic stem cell function

2002 - 2003 Gene therapy for chronic granulomatous disease combined with in vivo expansion of transduced hematopoietic cells.

2001 - 2003 Invesigation on signal transduction of erythropoietin in vascular smooth muscle cells

2002 - 2002 慢性骨随生白血病のSTI571耐性獲得におけるFKHRL1転写因子の役割

2000 - 2002 Establishment of model system for hematological disorders associated with mutated signal transduction molecules

2001 - 2001 FKHRL1転写因子の機能解析と血液疾患モデルの樹立

1998 - 2001 造血細胞のシグナル伝達

2000 - 2000 レチノイン酸による白血病細胞の赤血球分化決定機構の解析

1998 - 2000 Invesigation on cellular mechanism of erythropoietin induced hypertension

1997 - 1999 analysis of molecular mechanism of hematopoiesis and hematological disorders

1997 - 1997 赤芽球分化と巨核球分化決定機構の解析

1995 - 1997 Molecular control of the regulation of hemopoiesis and clinical application

1996 - 1996 赤芽球と巨核球分化の振り分け機構の解析

1996 - 1996 トロンボポエチン受容体と細胞内シグナル伝達機構の解析

1995 - 1995 エリスロポエチンシグナル伝達分子異常と造血障害の病態解析

1995 - 1995 トロンボポエチン細胞内シグナル伝達機構の解析

1994 - 1994 エリスロポイエチン受容体遺伝子構造異常と造血障害

1993 - 1994 Characterization of 85Kd protein tyrosine phosphorylated by erythropoietin stimulation

1992 - 1994 Analysis of collected primitive hemopoietic stem cells and its clinical application

1992 - 1992 エリスロポエチン刺激により特異的に誘導されるチロシンリン酸化蛋白質の解析

1989 - 1991 Isolation concentration, and preservation of hemopoietic stem cells and its clinical

1989 - 1989 ヒト巨核芽球性白血病細胞株の分化に伴って消失する細胞表面糖蛋白の解析

1988 - 1988 ヒト巨核球細胞株の産生する巨核球増殖因子について

1986 - 1988 Studies on multipotent stem cell clifferentiation using newly developed techniques an its clinical applications.

1987 - 1987 遺伝子組換えヒト造血因子の純化ヒト血液幹細胞に対する直接作用及び間接作用の解析

1985 - 1987 T cell and tumor cell purging of marrow cell suspension using monoclonal antibodies - Effect of technique

1986 - 1986 造血幹細胞の分化と白血病はどのようにかかわりをもつか?

Hematopoiesis and signal transduction