Rchr
J-GLOBAL ID：200901059211207364   Update date: Sep. 26, 2024

Umezawa Naoki

ウメザワ ナオキ | Umezawa Naoki
Affiliation and department：
Nagoya City University Graduate School of Pharmaceutical Sciences Department of Bioorganic-inorganic Chemistry

About Nagoya City University Graduate School of Pharmaceutical Sciences Department of Bioorganic-inorganic Chemistry


Job title： Professor
Homepage URL  (1)： http://www.phar.nagoya-cu.ac.jp/hp/ysk/index.html
Research field  (1)： Pharmaceuticals - chemistry and drug development
Research keywords  (3)： 分子プローブ ,  ポリアミン ,  ペプチド
Research theme for competitive and other funds  (23)：
  • 2022 - 2025 Solid-phase synthesis of novel polyamine-type oligomers with side-chain structures and their selective binding to target nucleic acids
  • 2021 - 2024 可逆的共有結合を用いたペプチド立体構造制御と機能創出
  • 2020 - 2023 Study on Application of Porphyrin-related molecules to Medicinal Sciences
  • 2017 - 2020 Development of chemiluminescent sensor molecules that efficiently work under near-physiological conditions
  • 2015 - 2018 Conformationally restricted polyamines: Solid-phase synthesis and biological evaluation
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Papers (74)：
  • Kousuke Takahashi, Yasumichi Inoue, Shigeaki Hida, Naoki Umezawa, Isamu Akiba, Mitsuo Umetsu, Toshihisa Mizuno. Target-selective cytosolic delivery of cargo proteins using the VHH-presented OLE-ZIP capsules. ChemRxiv. 2024
  • Yosuke Hisamatsu, Go Toriyama, Katsuhiro Yamamoto, Hiroshi Takase, Tsunehiko Higuchi, Naoki Umezawa. Temperature Control of the Self-Assembly Process of 4-Aminoquinoline Amphiphile: Selective Construction of Perforated Vesicles and Nanofibers, and Structural Restoration Capability. Chemistry - A European Journal. 2024. 30. 36. e202400134
  • Kousuke Takahashi, Taiki Nishiyama, Naoki Umezawa, Yasumichi Inoue, Isamu Akiba, Takehisa Dewa, Atsushi Ikeda, Toshihisa Mizuno. Delivery of external proteins into the cytoplasm using protein capsules modified with IgG on the surface, created from the amphiphilic two helix-bundle protein OLE-ZIP. Chem. Commun. 2024. 60. 968-971
  • Yosuke Hisamatsu, Fangzhou Cheng, Katsuhiro Yamamoto, Hiroshi Takase, Naoki Umezawa, Tsunehiko Higuchi. Control of the stepwise self-assembly process of a pH-responsive amphiphilic 4-aminoquinoline-tetraphenylethene conjugate. Nanoscale. 2023. 15. 7. 3177-3187
  • Wakao Fukuda, Mamoru Osaki, Yusuke Yasuda, Ryota Hidese, Tsunehiko Higuchi, Naoki Umezawa, Shinsuke Fujiwara, Eiichi Mizohata. Substrate Specificity of an Aminopropyltransferase and the Biosynthesis Pathway of Polyamines in the Hyperthermophilic Crenarchaeon Pyrobaculum calidifontis. Catalysts. 2022. 12. 5. 567
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MISC (39)：
  • 宮本 啓補, 澤田 雅人, 山崎 久朗, 梅澤 直樹, 樋口 恒彦, 粂 和彦, 澤本 和延, 大澤 匡弘. 成体海馬ニューロン新生に着目した痛みの慢性化を引き起こす中枢神経回路の解明. 日本薬学会年会要旨集. 2021. 141年会. 28V08-am08S
  • 北川智規, 西尾天志, 吉川祐子, 剣持貴弘, 梅澤直樹, 吉川研一. Enhancement and inhibition on gene expression by polyamines with different chemical structures: Effect of higher-order structural change of DNA. 日本ポリアミン学会年会プログラム及び抄録集. 2020. 11th
  • 北川智規, 西尾天志, 吉川祐子, 梅澤直樹, 樋口恒彦, 剣持貴弘, 吉川研一. ポリアミンの化学構造に依存したDNA高次構造変化と遺伝子発現に対する特異的な作用. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
  • 西尾天志, 吉川祐子, SHEW Chewen-Yang, SHEW Chewen-Yang, 梅澤直樹, 樋口恒彦, 吉川研一. 抗腫瘍活性を有するノルスペルミジンのDNAへの作用:DNAの高次構造変化と遺伝子発現活性. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
  • 北川智規, 西尾天志, 吉川祐子, 梅澤直樹, 剣持貴弘, 吉川研一. ポリアミンによる遺伝子発現の促進・抑制の二面性:DNA高次構造変化との相関. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
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Books (2)：
  • 新規モダリティ医薬品のための新しいDDS技術と製剤化
    技術情報協会 2023 ISBN:9784861049361
  • 薬学系のための基礎化学
    裳華房 2015 ISBN:9784785335069
Education (2)：
  • 1994 - 1999 University of Tokyo Graduate School of Pharmaceutical Sciences
  • - 1994 The University of Tokyo Faculty of Pharmaceutical Science
Professional career (1)：
  • 博士(薬学) (東京大学薬学系研究科)
Work history (5)：
  • 2022/11 - 現在 Nagoya City University Graduate School of Pharmaceutical Sciences Department of Bioorganic-inorganic Chemistry Professor
  • 2007/06 - 2022/10 Nagoya City University Graduate School of Pharmaceutical Sciences Associate Professor
  • 2005/06 - 2007/05 Nagoya City University Graduate School of Pharmaceutical Sciences Lecturer
  • 2002/04 - 2005/05 Nagoya City University Department of Pharmaceutical Sciences Assistant Professor
  • 1999 - 2002 University of Wisconsin, Madison Department of Chemistry Postdoctoral Fellow
Committee career (15)：
  • 2023/03 - 現在 日本化学会 東海支部 常任幹事
  • 2021/07 - 2021/07 日本薬学会 第67回東海支部大会 実行委員
  • 2019/06 - 2019/06 日本ケミカルバイオロジー学会 第14回年会プログラム委員
  • 2019/02 - 2019/02 日本酸化ストレス学会東海支部 第7回支部学術集会実行委員
  • 2017/03 - 2019/02 日本化学会 東海支部代議員
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Association Membership(s) (3)：
Chemical Society of Japan ,  The Pharmaceutical Society of Japan ,  American Chemical Society
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