Takahashi Masahiko

タカハシマサヒコ | Takahashi Masahiko

Affiliation and department：
Job title： Associate Professor

Research field (3)： Hematology and oncology , Neuropathology , Virology

Research keywords (5)：ウイルス感染症 , 神経変性 , 細胞生存 , ストレス顆粒 , タンパク凝集

Research theme for competitive and other funds (17)：

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Papers (39)：

Kanako Watanabe, Tomoichiro Oka, Hirotaka Takagi, Sergei Anisimov, Shun-ichi Yamashita, Yoshinori Katsuragi, Masahiko Takahashi, Masaya Higuchi, Tomotake Kanki, Akihiko Saitoh, et al. Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry. Nature Communications. 2023. 14. 1
Masahiko Takahashi, Hiroki Kitaura, Akiyoshi Kakita, Taichi Kakihana, Yoshinori Katsuragi, Osamu Onodera, Yuriko Iwakura, Hiroyuki Nawa, Masaaki Komatsu, Masahiro Fujii. USP10 inhibits aberrant cytoplasmic aggregation of TDP-43 by promoting stress granule clearance. Molecular and Cellular Biology. 2022. 42. 3. e0039321
Junya Sango, Taichi Kakihana, Masahiko Takahashi, Yoshinori Katsuragi, Sergei Anisimov, Masaaki Komatsu, Masahiro Fujii. USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity. Journal of Biological Chemistry. 2021. 298. 1. 101448-101448
Taichi Kakihana, Masahiko Takahashi, Yoshinori Katsuragi, Shun-Ichi Yamashita, Junya Sango, Tomotake Kanki, Osamu Onodera, Masahiro Fujii. The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43. iScience. 2021. 24. 7. 102733-102733
Naoyoshi Maeda, Akira Matsuda, Satoko Otsuguro, Masahiko Takahashi, Masahiro Fujii, Katsumi Maenaka. Antitumor Effect of Sugar-Modified Cytosine Nucleosides on Growth of Adult T-Cell Leukemia Cells in Mice. Vaccines. 2020. 8. 4. 658-658

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MISC (5)：

高地貴行, 由田真奈美, 高橋雅彦, 樋口雅也, 大家正泰, 小幡美貴, 三嶋行雄, 木南凌, 松岡雅雄, 藤井雅寛. 成人T細胞白血病ウイルス癌蛋白TaxとHBZはBCL11B遺伝子発現を抑制する(Human T-cell leukemia virus type 1 oncoproteins Tax and HBZ represses BCL11B gene expression). 日本癌学会総会記事. 2013. 72回. 240-240
M Fujii, M Takahashi, M Higuchi. Aberrant activation of the interleukin 2 autocrine loop through Nfat by non-leukemogenic human T-cell leukemia virus type 2 but not leukemogenic type 1 virus. AIDS RESEARCH AND HUMAN RETROVIRUSES. 2005. 21. 5. 451-451
FUJII Masahiro, HIRATA Akira, NIINUMA Akiko, TSUBATA Chikako, ISHIOKA Koujirou, Jo Rie, TAKAHASHI Masahiko, OIE Masayasu, HIGUCHI Masaya. Oncogenesis by a Human Retrovirus (Genome Information and Infection (Application for Diagnosis, Treatment, and Prevention)). Niigata medical journal. 2004. 118. 11. 601-606
若本裕晶, 森田裕, 高橋雅彦, 間陽子. モノクローナル抗体による牛白血病ウイルス表面抗原gp51の検出. 日本獣医学会学術集会講演要旨集. 2003. 135回. 123-123
S Tajima, M Takahashi, K Okada, Y Aida. In vitro and in vivo analyses of infectious molecular clone of BLV encoding tax with elevated transactivation activity. AIDS RESEARCH AND HUMAN RETROVIRUSES. 2001. 17. S48-S48

Lectures and oral presentations (18)：

USP10 inhibits aberrant cytoplasmic aggregation of TDP-43 by promoting stress granule clearance
(NEURO2022(沖縄) 2023)
G3BP1 and USP10 prevent aberrant cytoplasmic TDP-43 aggregation through interacting with TDP-43
(第43回日本神経科学大会(大阪) 2020)
USP10 is a critical factor in α-synuclein aggregation, aggresome and Lewy body formations but not GCI
(24th World Congress of Neurology 2019 (アラブ首長国連邦・ドバイ) 2019)
USP10 is a critical factor for aggresome formation to induce α-synuclein aggregation and Lewy body but not GCI
(NEURO2019(新潟) 2019)
HTLV-1の Tax蛋白はUSP10を介してROS産生とROS依存性アポトーシスを誘導する
(第61回日本ウイルス学会学術集会(神戸) 2013)

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Professional career (1)：

Work history (4)：

2016/11/01 - 現在 Niigata University Graduate School of Medical and Dental Sciences Community Disease Control Infectious Disease Control and International Medicine Associate Professor
2015/04/01 - 2016/10/31 Niigata University Graduate School of Medical and Dental Sciences Community Disease Control Infectious Disease Control and International Medicine Lecturer
2007/04/01 - 2015/03/31 Niigata University Graduate School of Medical and Dental Sciences Community Disease Control Assistant Professor
2004/04/01 - 2007/03/31 Niigata University Graduate School of Medical and Dental Sciences Assistant

Association Membership(s) (3)：

日本癌学会 , The Japanese Society for Virology , THE JAPAN NEUROSCIENCE SOCIETY

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